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Recommended Doses of Herbal Supplement Do Not Interfere With Drug Absorption

a ginseng supplement and a placebo for ginkgo biloba; the second received ginkgo biloba and a placebo for ginseng; the third received both ginseng and ginkgo biloba supplements; and the fourth received placebos for both supplements.

The prescription drug cocktail was again administered and blood and urine samples taken in order to determine the absorption and metabolism of these drugs in the presence of either or both of the herbal supplements.

The scientists found no significant differences between those who received one, both, or none of the ginseng and ginkgo biloba supplements in how their bodies absorbed or metabolized any of the five prescription drugs.

This suggests, says Dr. Reed, that neither ginseng nor ginkgo biloba will affect the pharmacokinetics of the majority of prescription or over-the counter drugs. He does note, however, that the team did not investigate any possible effects of the herbal supplements on pharmacodynamic interactions: the way drugs produce desired therapeutic effects or cause adverse side effects. The possibility of these pharmacodynamic, as opposed to pharmacokinetic, interactions remains to be investigated.


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