Navigation Links
Recommended Doses of Herbal Supplement Do Not Interfere With Drug Absorption

Recent findings that the widely-used herbal supplement Saint Johns wort could dramatically affect the absorption and metabolism of many prescription and non-prescription drugs raised concerns that other popular herbal supplements might cause similar changes, thus significantly altering drugs therapeutic or toxic effects.

What, for example, about ginseng and ginkgo biloba, two of the most widely used herbal supplements in this and other countries, Speaking at Experimental Biology 2007, University of Kansas Medical Center scientist Dr. Gregory Reed reports a study that found daily use of ginseng or ginkgo biloba supplements at the recommended doses, or the combination of both supplements, are unlikely to alter the pharmacokinetics - by which drugs are absorbed, distributed, metabolized, and eliminated by the body - of the majority of prescription or over-the counter drugs. Dr. Reeds presentation was part of the scientific program of the American Society for Pharmacology and Experimental Therapeutics.

The research team, led by Dr. Reed and the late Dr. Aryeh Hurwitz, recruited 72 healthy non-smoking adults (31 men and 41 women, ages 20 to 59) who were not taking any prescription drugs or dietary supplements.

The participants were given a cocktail of five drugs, each drug in the cocktail chosen because it provides a measure of the activity of a key drug metabolism pathway. Taken together, the five drugs in the cocktail provide measurements of the pathways that determine the pharmacokinetics of over 90 percent of prescription drugs.

The scientists then measured the presence of these drugs or their metabolites in each subjects blood and urine in order to establish a baseline for how each individual absorbed and metabolized the different prescription drugs in the absence of herbal supplements.

The 72 individuals next were randomly assigned to one of four groups. For four weeks, the first group received a ginseng supplement and a placebo for ginkgo biloba; the second received ginkgo biloba and a placebo for ginseng; the third received both ginseng and ginkgo biloba supplements; and the fourth received placebos for both supplements.

The prescription drug cocktail was again administered and blood and urine samples taken in order to determine the absorption and metabolism of these drugs in the presence of either or both of the herbal supplements.

The scientists found no significant differences between those who received one, both, or none of the ginseng and ginkgo biloba supplements in how their bodies absorbed or metabolized any of the five prescription drugs.

This suggests, says Dr. Reed, that neither ginseng nor ginkgo biloba will affect the pharmacokinetics of the majority of prescription or over-the counter drugs. He does note, however, that the team did not investigate any possible effects of the herbal supplements on pharmacodynamic interactions: the way drugs produce desired therapeutic effects or cause adverse side effects. The possibility of these pharmacodynamic, as opposed to pharmacokinetic, interactions remains to be investigated.


Related medicine news :

1. In Early Epilepsy Delay in medications Recommended
2. Exercises Should Be Recommended During Pregnancy
3. Drug Herceptin To Be Recommended To All Breast Cancer Patients
4. More Exercise Recommended For Fitness Of Cardiac Patients
5. Change In Lifestyle Recommended To Avoid Cardiac Disease
6. Few Medicaid Kids with Asthma Get Recommended Flu Shot
7. Updated Sleep Apnea Screening Recommended for Commercial Drivers
8. Booster Dose for Chickenpox Vaccine Recommended
9. Doubling Plavix Dose Recommended Before Angioplasty
10. India To Procure 1 Million Doses Of Tamiflu
11. Small Doses Of Radiation Can Help Certain Lung Cancer Patients
Post Your Comments:

(Date:11/26/2015)... Omaha, NE (PRWEB) , ... November 26, 2015 , ... ... careers searched by healthcare professionals and offered by healthcare staffing agency Aureus Medical ... top during the month of October 2015 among those searching for healthcare jobs through ...
(Date:11/26/2015)... CA (PRWEB) , ... November 26, 2015 , ... ... a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly ... options. These classically-influenced trailer titles work with any font, giving users limitless opportunities ...
(Date:11/25/2015)... ... 25, 2015 , ... Additional breast cancers found with MRI ... to a study published online in the journal Radiology. Researchers said that in ... a change in treatment. , Breast MRI is the most sensitive technique for ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the traditional and far-infrared ... traditional and far-infrared saunas. , For traditional saunas, Finnleo is offering ... sauna wood, and Finnleo uses only European Grade A Nordic White Spruce from sustainably ...
(Date:11/25/2015)... ... 2015 , ... Dr. John Pierce, Medical Director at the Ageless Forever clinic ... the Capillus272™ Pro laser therapy cap. FDA cleared for safety and efficacy, the Capillus272 ... need for surgery, prescription pills, or topical foams. , “Capillus272™ Pro is a ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Nov. 26, 2015  The total global healthcare industry is ... 2015-2016. Latin America has the highest ... (excluding Japan ), is second with growth ... to face increased healthcare expenditure. In 2013-2014, total government funded ... 43.5% in 2008-2009 to 41.2% in 2013-2014. In real terms, ...
(Date:11/25/2015)... Nov. 25, 2015  The American Academy of ... (ACOG), and the March of Dimes cheered today,s ... Our Infants Act of 2015 (S.799), which ... newborns born exposed to drugs, such as opioids, ... introduction, all three organizations have worked together leading ...
(Date:11/25/2015)... Nov. 25, 2015 AAIPharma Services Corp./Cambridge ... of at least $15.8  Million to expand its ... NC . The expansion will provide additional ... the growing demands of the pharmaceutical and biotechnology ... expansion will provide up to 40,000 square feet ...
Breaking Medicine Technology: