Navigation Links
Receptor for H.pylori Identified in Stomach

Bethesda, MD – Scientists have identified the receptor for Helicobacter pylori as the decay-accelerating factor (DAF), a protein found in epithelial cells in the stomach//.

Blocking this interaction could lead to new drugs that reduce the risk of peptic ulcer disease or gastric cancer. The research appears as the ‘Paper of the Week’ in the May 12 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Helicobacter pylori are spiral shaped bacteria that live in the thick layer of mucus that covers the stomach lining. The bacteria are found everywhere in the world, but are especially prevalent in developing countries, where up to 80% of children and 90% of adults can have laboratory evidence of an H. pylori infection--usually without having any symptoms.

The vast majority of H. pylori in colonized hosts are free-living, but approximately 20% bind to gastric epithelial cells. This binding induces an immune response and alters the morphology and behavior of the epithelial cells due to injection of bacterial proteins into the cells. This interaction can lead to peptic ulcer disease, gastric adenocarcinoma, and non-Hodgkins lymphoma of the stomach.

‘Ulcers are a breach in the gastric or duodenal mucosa and gastric adenocarcinoma is one type of cancer of the stomach,’ explains senior author Dr. Richard M. Peek, Jr. of the Vanderbilt University School of Medicine. ‘H. pylori alters acid production and can lead to increased acid outputs which causes peptic ulcer disease. The means through which H. pylori causes gastric cancer are more complex but likely involve alterations in gastric epithelial cell responses that are perturbed within the context of a chronic gastric inflammatory infiltrate, which can persist for decades.’

A membrane-imbedded protein found in the stomach called decay-accelerating factor (DAF) has been shown to function as a receptor for s
'"/>




Page: 1 2

Related medicine news :

1. Soluble IL-4 Receptor - A new boon for asthmatics
2. Toll-like Receptor (Tlr3) Attachment Leads To Lethal Encephalitis
3. Genetic Variation In Bitter-Taste Receptor Gene Increases Alcoholic Risk
4. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
5. Researchers Identify Lung Failure Therapy Receptor
6. Effects Of Certain Food Related To Single Pain Receptors
7. Functional Differences In Estrogen Receptor Could Be A Therapeutic Target
8. Schizophrenia Complicates With Altered Receptor Activity
9. Definite Connection Between Receptor Levels and Cocaine Abuse Reveals PET Imaging
10. Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer
11. Inhibitor That Blocks Host Receptors Found To be Effective In Treating Anthrax
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Receptor for pylori Identified Stomach

(Date:8/28/2014)... problem in winemaking is "stuck fermentation," when yeast that ... carbon dioxide prematurely shuts down, leaving the remaining sugar ... the wine. , A team of researchers including UC ... communication system behind this problem. Working through a ... itself -- the system enables bacteria in fermenting wine ...
(Date:8/28/2014)... Data from the American Hospital Association’s 2013 Annual ... a basic electronic health record (EHR) system, more advanced ... challenge. , This data is featured in an ... , and is co-authored by Peter Kralovec, executive director ... as Chantal Worzala, director for policy at the AHA. ...
(Date:8/28/2014)... Tenn. The New England Journal of Medicine ... clinical trial of a drug shown to safely reduce ... volunteers intranasally infected with respiratory syncytial virus (RSV). ... of Tennessee Health Science Center researcher Infectious Disease Specialist ... , RSV is the most common cause ...
(Date:8/28/2014)... hurting reproduction of the endangered Devils Hole pupfish, threatening the ... as 35 individuals, new research by the University of Nevada, ... geothermal water on a small shelf near the surface of ... live is heating up as a result of climate change ... , The hotter water, which now reaches more than 93 ...
(Date:8/28/2014)... GABLES, Fla (Aug. 26, 2014)-- Cigarette smoking kills ... Centers for Disease Control and Protection. It,s the ... to overcome this addiction, many people resort to ... review study by researchers at the University of ... found in cigarette substitutes could be harmful to ...
Breaking Medicine News(10 mins):Health News:Prions can trigger 'stuck' wine fermentations, researchers find 2Health News:AHA Data Shows Progress, Challenges on Road to Healthcare IT Adoption 2Health News:AHA Data Shows Progress, Challenges on Road to Healthcare IT Adoption 3Health News:DeVincenzo study breakthrough in RSV research 2Health News:Climate change puts endangered Devils Hole pupfish at risk of extinction 2Health News:Climate change puts endangered Devils Hole pupfish at risk of extinction 3Health News:Are cigarette substitutes a safe alternative? It depends on user habits 2Health News:Are cigarette substitutes a safe alternative? It depends on user habits 3
... expect from a wine.It's important to know how I plan to ... Federal Association of German Wine Cellars and Wine Sales, here. ... accompany a meal or is to be enjoyed with a good ... what to drink. A shopper has to decide whether they prefer ...
... Researchers at the University Of Pennsylvania School Of Medicine ... virus (EBV) protein and a vital cancer pathway earlier ... research and have found that the viral protein, named ... ,This protein is very necessary in controlling cell ...
... Ranjan Dasmunsi, Information and Broadcasting Minister said that Dr. Manmohan ... join the International Agency// for Research on Cancer (IARC). ... in the country. This membership will help in the development ... environmental risk factors and facilitate the development of initial preventive ...
... in our ancestors, they gave more gifts to the ... habit of exchanging gifts and foods between// them which ... Gurven, University of California said, "Reciprocity is arguably the ... feature of reciprocity is the contingent relationship between acts ...
... between Apollo Hospitals and the Stanford Emergency Medicine ... of a first-ever international programme for training of ... time programme would be conducted at Apollo Hospitals, ... or an equivalent examination are eligible to enroll ...
... Becares, Ph.D, student at Public University of Navarre has ... found to have anti-cancer effects//. She tested 24 compounds ... it had antitumor activity when tested in invitro cell ... have antitumor activity and she feels that still a ...
Cached Medicine News:Health News:Festive Tip For Wine Shoppers 2
(Date:8/28/2014)... 28, 2014  Seres Health, a clinical-stage therapeutics ... the human microbiome, announced today that Dr. ... R&D and Chief Scientific Officer, will be presenting ... and Chemotherapy (ICAAC). The presentation will highlight the ... mixture of bacterial spores derived from the human ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire-iReach/ -- Gateway ... at the 9 th Annual Global Pharma ... , September 8-9 th . The Global Pharma ... leaders in small molecule and biologic pharmaceutical manufacturing. ... challenges that today,s manufacturers face, such as the ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces ... is available in its catalogue: ... Markets to 2020 - Novel Therapeutic ... Newly Diagnosed and Recurrent GBM ... Glioblastoma Multiforme Therapeutics in ...
Breaking Medicine Technology:Seres Health to Present Clinical Findings at ICAAC 2014 Conference 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 2Gateway Analytical to Promote Particulate Identification Services at the 9th Annual Global Pharma Manufacturing Summit 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 2Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 3Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 4Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 5Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 6Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 7Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 8Glioblastoma Multiforme Therapeutics in Asia-Pacific Markets to 2020 - Novel Therapeutic Approaches Target High Unmet Need in Newly Diagnosed and Recurrent GBM 9
... HAYWARD, Calif., Oct. 27, 2011  Questcor Pharmaceuticals, Inc. (NASDAQ: ... partnering with the Child Neurology Foundation (CNF) in support ... which will take place October 24-30, 2011, in conjunction ... Savannah, Georgia. As part of this education ...
... Inland Northwest Health Services (INHS), one of ... collaboration with Science Applications International Corporation (SAIC) (NYSE: ... enabling the secure exchange of electronic health information ... part of the Electronic Disability Benefits Eligibility Determination ...
Cached Medicine Technology:Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 2Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 3Questcor and Child Neurology Foundation Support the 3rd Annual Infantile Spasms (IS) Awareness Week 4
Stainless steel. Lamp is in fiberoptic handle. Green color coding. The blade includes a port that permits delivery of oxygen or other gas mixtures during intubation....
... of the vocal cords in even the most ... like a standard laryngoscope, Viewmax® does not require ... its ability to allow intubation whether you are ... airway. It has a patented lens system that ...
... Stainless steel. Lamp supplied with ... operate on any standard/conventional handle allowing ... illumination without the potential confusion from ... blades offer an easy and cost ...
... The FR-120F, Fujinon's new fiberoptic Naso-Pharyngo-Laryngoscope provides ... patient comfort. The latest in Fujinon ... increased light guide, and a wide 90 ... impressive 3.3mm distal tip diameter. In ...
Medicine Products: