Navigation Links
Reason for diabetes drug causing edema discovered

Researchers had been able to find out why the diabetes drug thiazolidinediones (TZDs) can cause //edema.

Scientists from the University of Utah had found that the drug TZDs activates a receptor in kidney called peroxisome proliferator-activated receptor gamma (PPAR). This is situated in the collecting duct of the kidney. The activation of the receptor serves to retain the fluid in the body and causes edema.

TZD drugs are generally used to lower blood sugar levels and lipid levels and help in controlling blood pressure. However some people can get pulmonary edema and increased risk of chronic heart failure from the drug as side effects.

TZD works by activating PPAR gamma receptor that helps the body to use the insulin to increase metabolism and control blood glucose levels.

The research results showed that in mice the drug caused bloating with increase in body weights. This shows that there is fluid retention in the body that is causing edema. The receptor affects the distal nephron, which plays an important role in deciding the sodium metabolism in the body. Imbalance in sodium retention is one of the causes suspected by the scientists in causing edema.

Reference: Proceedings of the National Academy of Sciences, June 2005

Page: 1

Related medicine news :

1. Reasons why men die earlier
2. A Reason To Smile
3. The Reason For Depression in Adolescents
4. Sun The Reason To Blame for eye Disease
5. The Reason For Loss Of Appetite After Gastric Bypass
6. Reasons For Low Back Pain
7. Abnormal Brain Structure One Of The Reasons For Depression in Adolescents
8. The Reason For Depression in Adolescents
9. Testosterone patch for women Rejected For safety Reasons
10. Yet Another Reason To Celebrate Drinking
11. Indian Researcher Discovers Reason For Malignancy of Skin Cancer
Post Your Comments:

(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of ... recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at Work ... Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology: