Researchers had been able to find out why the diabetes drug thiazolidinediones (TZDs) can cause //edema.

Scientists from the University of Utah had found that the drug TZDs activates a receptor in kidney called peroxisome proliferator-activated receptor gamma (PPAR). This is situated in the collecting duct of the kidney. The activation of the receptor serves to retain the fluid in the body and causes edema.

TZD drugs are generally used to lower blood sugar levels and lipid levels and help in controlling blood pressure. However some people can get pulmonary edema and increased risk of chronic heart failure from the drug as side effects.

TZD works by activating PPAR gamma receptor that helps the body to use the insulin to increase metabolism and control blood glucose levels.

The research results showed that in mice the drug caused bloating with increase in body weights. This shows that there is fluid retention in the body that is causing edema. The receptor affects the distal nephron, which plays an important role in deciding the sodium metabolism in the body. Imbalance in sodium retention is one of the causes suspected by the scientists in causing edema.

Reference: Proceedings of the National Academy of Sciences, June 2005
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