Navigation Links
Rare Nerve Disease Causing Gene Identified

The Researchers from UK and US working together explained that they have identified the gene that was behind a group of rare, progressive childhood //disorders caused by an abnormal build up of iron in the brain.

Explaining about the discovery of the PLA2G6 gene, whose mutated forms trigger several genetic disorders categorized as neuroaxonal dystrophies, they said that this could also shed light on the nerve cell degeneration that leads to neurological problems such as Parkinson's and Alzheimer's diseases, both known to be associated with brain iron accumulation.

The study in Nature Genetics has found a defect in phospholipases; a specific group of proteins was responsible. The researchers conducted the studies on the families hat were affected by two of the genetic disorders infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation. (NBIA)

They explained that both the disorders are characterised by an abnormal build-up of iron in the brain, which causes the branch-like axons that transmit electrical impulses in nerve cells to swell, thereby interrupting the signal. They said that this causes the affected children to suffer from progressive loss of vision.

The researchers collected DNA from 30 to 40 families and narrowed the search for the suspect gene to chromosome 22. Then searching for genes in the region whose function was suggestive of the symptoms and the parts of the body affected by the diseases, they narrowed the search further to 75 genes.

After combing the 75 genes patiently, they identified the mutations in PLA2G6, which codes for a protein belonging to a group called phospholipase A2. They explained that when the gene is mutated it alters the processes inside a cell that leads to the build up of iron, which incidentally is also seen in conditions like Alzheimer's and Parkinson's.

Both these diseases are due to recessive traits, meaning that both par
'"/>




Page: 1 2

Related medicine news :

1. Epilepsy Drug Helps Diabetic Nerve Damage
2. World’s First Nerve Stem Cells Produced
3. Children With Epilepsy Can Be Treated With Nerve Stimulation
4. FDA Approved Nerve-Stimulation Therapy Now Available In New York
5. Doctors Finish Mother-To-Son Nerve Surgery
6. Stem Cells From Hair Follicle To Repair Nerve Damage
7. Nerve regeneration for Spinal cord injuries
8. Novel Protein, Staufen2 Important In Maintenance Of Nerve Synapses
9. Dividing Nerve Cells Could Trigger Alzheimers Disease
10. Protein Found to Be Essential For Maintaining Nerve Health
11. Nerve Stimulator for Depression Though Not Effective Was Given Approval
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Rare Nerve Disease Causing Gene Identified

(Date:10/20/2014)... October 20, 2014 My Clients Plus ... software application. The new module enables easy administration ... full life-cycle quality care. , This application allows users ... their practice, attach a to-do item to a specific ... even set up reoccurring reminders for follow-ups. It's ...
(Date:10/20/2014)... Oregon (PRWEB) October 20, 2014 Succeed is ... of local companies who participated in the Every Body ... is a public awareness project that encourages workers to be ... Summer Step 10,000 Program, which concluded at the end of ... variety of cities and metro areas. Participating companies gave ...
(Date:10/20/2014)... 2014 It’s hard to imagine what it’s ... vulnerable children around the world, it’s a reality. And while ... children are forced to walk barefoot on rocky terrain or ... play with their friends. , Buckner International's Shoes ... Radio in October to encourage support for Air1 and ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently announced ... the best Dedicated Server Hosting suppliers. Their websites ... buy high quality hosting and save money at ... Top10BestSEOHosting.com says, “We believe that iPage and GreenGeeks ... lot of the global clients enjoy using their ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest hosting ... HostMonster are the best VPS hosting suppliers in ... the method of partitioning a physical server computer ... appearance and capabilities of running on someone’s own ... close attention to VPS products and related suppliers. ...
Breaking Medicine News(10 mins):Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2
... , All amounts are in U.S. dollars , QUEBEC CITY, ... AEZ) (the "Company"), a global biopharmaceutical company focused on endocrinology ... and for the three-month and nine-month periods ended September 30, ... - July 7, 2009. Publication in Proceedings ...
... Disability Companies are pleased to announce Newborn and Parenting Resources ... to their newborn baby and return to work after maternity ... and in-force short term disability plans offered by the affiliates ... and Parenting Resources once their baby arrives and their short ...
... LONDON, November 11 Extensive research conducted ... University of,Sheffield on the Simbionix PROcedure Rehearsal Studio(TM), was ... 2009 congress in Lisbon, Portugal. , ... year, is,the world,s first patient specific system to enable ...
... Internationally recognised ... will talk the audience through each step of the procedure as the laser treatment is ... ... iLASIK procedure in a free live broadcast. He will talk the audience through each step ...
... ... perform the latest minimally invasive single as well as double hip replacement procedures. , ... (Vocus) June 29, 2009 -- Noted ... as the 135-year-old downtown hospital,s Medical Director of Joint Replacement and Reconstruction, Dr. Thomas Whitten, ...
... ... across medical disciplines , ... Englewood, CO (Vocus) November 11, 2009 -- HEALTHeCAREERS , North America’s premier ... economy’s record unemployment rate, the medical industry continues to be one of the few ...
Cached Medicine News:Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 2Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 3Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 4Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 5Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 6Health News:AEterna Zentaris Reports Third Quarter 2009 Financial and Operating Results 7Health News:WellPoint's Affiliated Life and Disability Companies Offer Newborn and Parenting Resources to Ease New Mothers' Transition Back to Work After Maternity Leave 2Health News:Research on Simbionix PROcedure Rehearsal Software Awarded Magna Cum Laude Prize at CIRSE 2009 2Health News:Research on Simbionix PROcedure Rehearsal Software Awarded Magna Cum Laude Prize at CIRSE 2009 3Health News:Eye Surgeon Broadcasts own Surgery 2Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 2Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 3Health News:Healthcare Web Site Boasts Thousands of Jobs in a Down Economy 2
(Date:10/17/2014)... N.C. , Oct. 17, 2014  Training ... is a critical success factor in today,s highly ... develop market research organizations that effectively and efficiently ... specialty or service area. Effective ... value and earn recognition from internal clients by ...
(Date:10/17/2014)... -- Research and Markets  has announced the ... of China Dialysis Market, 2014-2018" report to ... 2013 version, this update Report provides detailed analysis ... the relevant effect in recent three years, and ... it analyzes Chinese private-owned hemodialysis services. In the ...
(Date:10/17/2014)... BALTIMORE, Md. , Oct. 17, 2014 /PRNewswire-USNewswire/ ... Center for Medical Technology Policy: The ... from the FDA, public and private payers, medical ... representatives, clinicians, and other experts January 12, 2015 ... effectiveness and value of weight loss treatments.  Participants ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
... 24, 2012 BioNeutral Group, Inc. (OTCBB: BONU), ... jointly announced today a collaborative research and revenue ... trial Ygiene 206, a detergent cleaner, 90-second disinfectant ... new formulations designed for rapid cleaning and sterilization ...
... HILLS, Calif., Jan. 24, 2012  LoneStar Heart Inc., based ... Coats, M.D., and Mark Maciejewski to the company,s board ... chairman of the board for LoneStar Heart; Frank Ahmann, ... Cohen, chief executive officer of Vessix Vascular, Inc.; and ...
Cached Medicine Technology:BioNeutral and Barnabas Health to Collaborate for Surgical Instrument Sterilization 2BioNeutral and Barnabas Health to Collaborate for Surgical Instrument Sterilization 3LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 2LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 3
Ideal for use with our High Beam headlight. Rotating Turret allows use with other manufacturer's cables. Infinite intensity control. Excellent color definition (6000 K Color Temperature)....
... Lite positions directly over one,eye permitting ... lens an exclusive feature ,resulting ... optic light that penetrates,deep into a ... swivel mount enables the,surgeon to rotate ...
Mounted on a fully adjustable molded,headband with crown strap and comfort,cushions, the sturdy Halogen III Classic is,lightweight, comfortable and durable....
... a product of AlloSource, one of ... tissue processing, and Interpore Cross, a ... InterGro combines AlloGro DBM with a ... a unique bone graft that offers ...
Medicine Products: