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Rare Mutation Causes Early Heart Disease and Metabolic Syndrome

wn to be involved in development and in certain forms of cancer. The mutation changed one amino acid in the protein, which the team showed altered the activity of the protein encoded by LRP6.

“The reason for the observed association of multiple risk factors with one another has been a mystery,” Lifton said. “Our findings have implicated the Wnt signaling pathway in the development of many risk factors and early CAD. We expect that studies of the Wnt signaling pathway in patients with early CAD, and metabolic syndrome, will provide new insight into the basic biology of disease causation and allow new approaches to disease prevention.”

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