Navigation Links
Radioprotective effect of Heat Shock Proteins

Radiation therapy for head and neck cancer often results in radiation-induced damage of the salivary glands. According to researchers//, targeted over-expression of heat shock protein 25 (HSP 25) could prevent this damage.

The report by Lee et al., "Radioprotective effect of HSP25 on submandibular glands of rats," is published in the November issue of The American Journal of Pathology.

Patients with head and neck cancer often receive radiation therapy as part of their treatment. However, the salivary glands, which frequently reside within the irradiation field, can become damaged at the same time. The resulting salivary dysfunction may involve dry mouth, oral infections, dental caries, and difficulty eating, some of which persist long after treatment ends, even permanently.

Dr. Yun-Sil Lee and colleagues examined whether salivary glands could be protected by heat shock proteins (HSPs), which are expressed by cells in an effort to counteract environmental stressors such as heat, hypoxia, and ionizing radiation. Using adenoviral vectors, the researchers specifically overexpressed HSP25 and HSP70i in submandibular salivary glands of rats. Rat salivary glands were then irradiated and monitored for radiation-induced changes.

In treated rats, HSP25 protected salivary gland function by maintaining gland weight, salivary flow rate, and salivary fluid composition, whereas HSP70i significantly protected only salivary flow rate. When specific damage to the glands was assessed, HSP25 and HSP70i both greatly diminished scarring, nuclear damage, and cell death (apoptosis), but HSP70i was slightly less effective. Finally, HSP25 and HSP70i preserved expression of aquaporin 5, which is important for water transport in salivary glands.

It is interesting to note that the results with HSP25 were similar to those observed with amifostine, an FDA-approved radioprotective drug. However, differences did exist: only amifostine protected all
'"/>




Page: 1 2

Related medicine news :

1. Morning after pill effective up to five days after having unprotected sex
2. Distraction therapy found very effective in postoperative patients
3. Just spice it up!!!!! Anti bacterial effects of spices unraveled in the West
4. TELITHROMYCIN - the proven effective new drug for cap
5. Protective effects of tomatoes in prostate cancer
6. Iron supplementation for a common side effect
7. Digital mammography proves effective
8. The effect of heart rate in middle aged men
9. Treatment for pre-menstrual syndrome is ineffective
10. Toxic effects common with AIDS treatments
11. Cost-effective antibiotics for sinusitis treatment
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Radioprotective effect Heat Shock Proteins

(Date:1/23/2015)... 2015 Hastings and Hastings, a law firm ... record number of legal representation client review requests for slip ... a steady rise in the number of slip and fall ... throughout the Valley. With that said, a large number of ... an experienced law firm. Hastings and Hastings is a personal ...
(Date:1/22/2015)... 2015 Liberty University has received accreditation for ... from the Council for Accreditation of Counseling & Related ... Center for Counseling & Family Studies , is under ... university’s new School of Behavioral Sciences. Prior to the formation ...
(Date:1/22/2015)... January 22, 2015 Woodloch Pines, an ... been selected by TripAdvisor as the number one best large ... best in the world for their annual Travelers’ Choice Awards. ... community . The website is home to millions of unbiased ...
(Date:1/22/2015)... is a seasoned and trusted leader who consistently delivers trendy ... have it lead the wedding dress industry into the future. ... for the global market. , “The CEO of VogueQueen is ... on continuing the goal of operational excellence and giving back ...
(Date:1/22/2015)... January 22, 2015 Blue Cross and Blue ... who exemplify what it means to “Live Fearless.” ... people to share their stories about how they or someone ... inspired others by living in the moment. By telling these ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:Liberty University's Resident Master’s Counseling Program Receives CACREP Accreditation 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2
... British Medical Association (BMA) plans collaboration with the Indian Medical ... opportunities for medical graduates to train in Britain. ... attend the 81st national conference of the IMA, said: "I ... Kumar and he was eager for a close and active ...
... correction patients will be benefited equally with Lasik surgery ... are equally safe and// beneficial. ,Both surgeries ... rectify the shape. Lasek (laser-assisted subepithelial keratectomy) involves cutting ... in doing away with some of the potential flap ...
... has suggested that Thursday may not be a good day after ... end up waiting longer in the hospital.// ,The Institute ... trend for five years have blamed the procedures in the NHS ... as it is thought to be. ,It was found ...
... about a potential hepatitis risk for those who ate at ... that those who consumed food from McDonald's Greenlane on the ... A. The medical officer confirmed that a particular food handler ... highly infectious stage of the virus. It is possible, since ...
... take the anti-bird flu initiative forward, in 2007. There has been ... to the spending allocated in 2006. ,According to the ... Krishnamurthi, the added spending on bird flu control will hopefully infuse ... have been 74 human cases of bird flu, out of which ...
... The novel vaccine that is being formulated by scientists, promises protection ... efficient to fight 24 strains// of influenza A virus, that ... flu. ,Two injections of this vaccine is expected to ... vaccine that has to be repeatedly administered every year. ...
Cached Medicine News:
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
(Date:1/22/2015)... a privately held medical device company, announced today that ... ITOCHU Corporation (Tokyo Stock Exchange TYO: 8001) to sell ... cancer in Japan . ViewRay,s technology, ... only MRI-guided radiation therapy system that images and treats ...
(Date:1/22/2015)... Jan. 22, 2015  Amgen (NASDAQ: AMGN ) today announced ... financial results on Tuesday, Jan. 27, 2015, after the close of ... conference call with the investment community at 2 p.m. PT. Participating ... , chairman and chief executive officer, and other members of Amgen,s ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
... South Dakota pharmaceutical company, pharmaCline ™ , has launched ... statement.  On November 23, 2011, pharmaCline became a part ... spot on the CBS jumbo screen located in Times ... through January 1, 2012. (Logo:  http://photos.prnewswire.com/prnh/20111202/MN16158LOGO ...
... Dec. 1, 2011 Demands from senior management ... commercial functions searching for best-in-class organizational structures. Comparing ... in place at peer companies through benchmarking data ... To support pharmaceutical vice presidents, directors, ...
Cached Medicine Technology:pharmaCline Launches "pharmaCline Can Help" Campaign 2Organizational Design and Structure Benchmarks for Pharmaceutical Commercial Functions Accessed Quickly Through Best Practices, LLC's New Database Search Function 2
DiaMed-ID Micro Typing System...
ScanGel® Incubator...
... Three different sized High-Throughput Submarine Systems ... of samples from microtitre plates. Analyze ... fragments, synthetic oligos or PCR products ... pipetting for accuracy and speed with ...
... The Mini-PROTEAN 3 Dodeca cell runs up ... in just 35 minutes. Handcast gels can ... the new Model 485 gradient former and ... variation and improving reproducibility. Alternatively, Ready Gel ...
Medicine Products: