Navigation Links
Radioprotective effect of Heat Shock Proteins

Radiation therapy for head and neck cancer often results in radiation-induced damage of the salivary glands. According to researchers//, targeted over-expression of heat shock protein 25 (HSP 25) could prevent this damage.

The report by Lee et al., "Radioprotective effect of HSP25 on submandibular glands of rats," is published in the November issue of The American Journal of Pathology.

Patients with head and neck cancer often receive radiation therapy as part of their treatment. However, the salivary glands, which frequently reside within the irradiation field, can become damaged at the same time. The resulting salivary dysfunction may involve dry mouth, oral infections, dental caries, and difficulty eating, some of which persist long after treatment ends, even permanently.

Dr. Yun-Sil Lee and colleagues examined whether salivary glands could be protected by heat shock proteins (HSPs), which are expressed by cells in an effort to counteract environmental stressors such as heat, hypoxia, and ionizing radiation. Using adenoviral vectors, the researchers specifically overexpressed HSP25 and HSP70i in submandibular salivary glands of rats. Rat salivary glands were then irradiated and monitored for radiation-induced changes.

In treated rats, HSP25 protected salivary gland function by maintaining gland weight, salivary flow rate, and salivary fluid composition, whereas HSP70i significantly protected only salivary flow rate. When specific damage to the glands was assessed, HSP25 and HSP70i both greatly diminished scarring, nuclear damage, and cell death (apoptosis), but HSP70i was slightly less effective. Finally, HSP25 and HSP70i preserved expression of aquaporin 5, which is important for water transport in salivary glands.

It is interesting to note that the results with HSP25 were similar to those observed with amifostine, an FDA-approved radioprotective drug. However, differences did exist: only amifostine protected all components of salivary fluid from change, but HSP25 afforded better protection from apoptosis than amifostine.

These results demonstrate the radioprotective effects of both heat shock proteins, with HSP25 providing the stronger defense. Thus, HSP25 delivery may represent a novel means of preventing the collateral damage associated with radiation therapy.

Source-Eurekalert
GYT
'"/>




Related medicine news :

1. Morning after pill effective up to five days after having unprotected sex
2. Distraction therapy found very effective in postoperative patients
3. Just spice it up!!!!! Anti bacterial effects of spices unraveled in the West
4. TELITHROMYCIN - the proven effective new drug for cap
5. Protective effects of tomatoes in prostate cancer
6. Iron supplementation for a common side effect
7. Digital mammography proves effective
8. The effect of heart rate in middle aged men
9. Treatment for pre-menstrual syndrome is ineffective
10. Toxic effects common with AIDS treatments
11. Cost-effective antibiotics for sinusitis treatment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our ... PROTECTION TO YOUR HEAD ™”. , “We are proud to introduce Meghan ... football front we have Brian Quick, wide receiver for Los Angeles who was a ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... to provide strategic sales leadership and to further develop their rapidly expanding portfolio ... in Business Administration with a concentration in Marketing and an M.B.A. with concentration ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... . With over 20 years of experience in leading technology and human resources ... years of university teaching, Morrow-Fox will be featured on Metcalf’s VoiceAmerica radio ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... safety efforts for several years, and the efforts have paid off. Since ... include new standards of care to enhance perioperative patient experiences and reduce costly ...
(Date:5/26/2016)... ... , ... May 2016 – Lips may be a central feature on our ... numbers of clients now ask about lip plumping and primping techniques and want tips ... Advanced Dermatology P.C. , The trend is a national one, with 2.4 ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25,2016 ... the near-infrared Cellvizio platform for urological and surgical ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal ... regulatory milestone in the US with the 12 ... and Drug Administration (FDA). This new FDA clearance ...
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... dringenden Bedarf zur Steuerung ... N.V. (NASDAQ: QGEN ; Frankfurt Prime ... Entwicklungsvereinbarung mit Therawis Diagnostics GmbH zur Entwicklung und ... sein. Ein erstes Projekt wird die Entwicklung und ...
Breaking Medicine Technology: