Navigation Links
RNA Play a Vital Role in Gene Activity

e finding marks the first time that ncRNA has been shown to affect gene expression on a chromosome other than its own.

The researchers believe that HOTAIR functions by affecting chromosomal packing in the nucleus. Inactive chromosomal regions are tightly wound around proteins called histones and cannot be copied into RNA. Loss of HOTAIR in skin cells specifically frees the HOXD control region for binding by activating proteins.

"Next we need to find out how these RNAs work structurally," said Rinn, "and what upstream regulatory molecules might be controlling their expression." They have one clue: HOTAIR binds to and activates a group of enzymes called the Polycomb Repressive Complex 2 that modifies histones and helps them wind up the DNA.

The researchers' interest is more than just theoretical. Polycomb proteins are improperly regulated in some types of cancers. HOX gene expression patterns are likely important to keep stem cells from improperly differentiating into skin, muscle, or other tissues. Understanding how ncRNAs affect these processes will have important implications for cancer therapies and stem cell research, they believe.

"We are really interested in how ncRNA finds its putative target in the genome," said Chang. "There remains a whole level of biological complexity to be explored, including how HOTAIR knows where to go, how it talks to other factors and how it controls histones."

The work will also provide insight into the evolution of gene regulation. Because RNA is thought to have preceded DNA in the evolutionary timeline, it makes sense that it still plays a role in controlling DNA's function.

Rinn and Chang's Stanford collaborators on the research include cancer biology graduate students Jordon Wang and Xiao Xu; surgical postdoctoral scholar Samantha Brugmann, PhD; research assistant Henry Goodnough; and Jill Helms, PhD, associate professor of surgery. Non-Stanford
'"/>




Page: 1 2 3 4

Related medicine news :

1. Fat Consumption Could Play A Vital Role In Affecting A Child’s Memory
2. Brain Plays Vital Role In Maintaining Bone Density
3. Sex Played A Vital Role For Evolution Of Infectious Diseases
4. Cancer Patient Denied Vital Drug
5. Telomerase Vital In Maintaining Ability of Stem Cell to Multiply
6. Parental Knowledge Of RSV Infections Is Vital
7. Calcium Receptor Vital For Stem Cell Migration to Bone Marrow
8. Aluminium and Iron Could Play a Vital Role in Multiple Sclerosis
9. Alcohol Consumption Pattern Plays A Vital Role in Alcohol Related Injury
10. Urban Built Environment May Play a Vital Role in Influencing the Body Size
11. Non-Coding RNA Vital For Gene Activation And Protein Expression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: RNA Play Vital Role Gene Activity

(Date:12/22/2014)... Coral Gables, FL (PRWEB) December 22, 2014 ... head lice removal service , Lice Troopers, with its new ... established in southern Florida, takes the hassle out of dealing ... removal services in one of their two salon clinic locations ... home or other location. , The decision to expand developed ...
(Date:12/22/2014)... December 22, 2014 The holidays are here, ... the season. Many may be thinking about how to enjoy ... a few weeks. Health Republic Insurance of New York has ... Andrea Chernus, to provide some smart ideas to enjoy the ... , 1)    Avoid arriving at a holiday gathering over-hungry , Have ...
(Date:12/22/2014)... China (PRWEB) December 22, 2014 Physicians ... MabThera (rituximab) for the treatment of non-Hodgkin’s lymphoma (NHL), ... , a leading global healthcare consulting firm. MabThera is ... lymphoma (DLBCL), the most common form of NHL. , ... Access and Barriers,” the incidence of NHL in China ...
(Date:12/22/2014)... December 22, 2014 Only weeks following ... and mid-western cities to have a battery manufacturer create ... ( http://www.talklocal.com ) is launching in Henderson ... , “A strong manufacturing sector is going to ... Gurpreet Singh explained, “and TalkLocal works with small businesses ...
(Date:12/22/2014)... Pasadena sleep apnea dentist, Dr. Marine ... drivers are 15 times more likely to cause deadly ... experts believe that sleep-deprived drivers may be just as ... of Americans may be sleep-deprived without even knowing it. ... 18 million Americans have sleep apnea, but as many ...
Breaking Medicine News(10 mins):Health News:Professional In-Home All-Natural Lice Removal Service Expands to Coral Gables and surrounding areas. 2Health News:Health Republic Insurance of New York Offers Five Simple Tips to Eat Healthy During the Holidays 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Pasadena Dentist, Dr. Marine Martirosyan, Now Offers Consultations for Sleep Apnea 2
... network for the NHS, that would cost ?300 million. // ... of IT companies comprising of Atos Origin, BT, IBM, and ... NHS with national computer services for 11 years. ... and nurse rosters. ,The consortium has decided to ...
... a rather unique show of exemplary medical prowess and ... John Hopkins //Comprehensive Transplant Center. This maiden feat was ... and 18 nurses and it took place over 10 ... the hospital has confirmed the good health of the ...
... Foundation's Health Literacy Conference reports on the relationship between ... patients could not explain why they take the prescribed ... should they take them. About half of the ... the research. ,Low health literacy is the ...
... study has found that sex does not increase the chances ... 20 times, contrary to movie mythology. //The study reported that ... use of cocaine could lift the likelihood 20-folds’. ... the first to analyse triggers for heart attacks, including sexual ...
... to lower the risk of dementia according to recent research. ... have a lower risk of dementia and Alzheimer’s disease. ... a key factor that is required for the proper functioning ... in this month’s issue of the Archives or Neurology. ...
... of AIDS cases reported from strife-torn Afghanistan, have grown from ... of heroin has raised concern amongst health authorities as a ... nation. , ,Anti-narcotics Minister Mohammad Zafar explained how the ... 7,000 in 2003, to 14,000 in 2005. , ,'Forty ...
Cached Medicine News:Health News:Maiden Quintuple Kidney Transplant Sets a Record 2Health News:Low Health Literacy Is The Major Cause For Patient Errors 2
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a global leader ... today announced it will participate in the 33 rd ... in San Francisco . ... speak at 11:00 AM Pacific Time.  A live audio webcast ... Investor Relations link on the Cyberonics home page at ...
(Date:12/22/2014)... DIEGO , Dec. 22, 2014  Pfenex Inc. ... Pfenex,s recombinant anthrax vaccine, has been filed and is ... funding provided by the Department of Health and Human ... Authority (BARDA). "We are extremely pleased to ... vaccine, Px563L.  This represents a significant milestone in our ...
(Date:12/19/2014)... 2014  Newport Corporation (NASDAQ: NEWP ... joined the company,s Board of Directors.  Dr. Kadia ... director of Evans Analytical Group, a leading global ... services to companies in a wide range of ... Analytical Group, Dr. Kadia spent nine years with ...
Breaking Medicine Technology:Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 2Pfenex Announces Active IND and Additional BARDA Funding for Recombinant Anthrax Vaccine Program, Px563L 3Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2
... Feb. 23, 2011 Reportlinker.com announces that a ... catalogue: Global Medical Ultrasound ... This report analyzes the worldwide ... by the following end use segments: Radiology, Cardiology, ...
... Calif., Feb. 23, 2011 Omnicell, Inc ., ... medication management systems to healthcare facilities, today announced the ... healthcare executives were polled to identify trends in requirements ... decisions. The survey found that the majority of hospitals ...
Cached Medicine Technology:Reportlinker Adds Global Medical Ultrasound Equipment Industry 275 Percent of Hospital IT Leaders View Interoperability Between Vendor Systems as Critical to Operational Effectiveness in Healthcare Settings 2
Open armhole design with Velcro release enables removal without compromising sterile field. Loops attached at shoulders for proper hanging & storage...
The most comfortable and easy to use apron in the industry. This front protection apron comes with a fully adjustable snap-on 5" orthopedic belt to relieve weight off your shoulders. Velcro strap acr...
Six inch wide elastic belt transfers the apron weight off the shoulders. 0.5mm front and 0.25mm back with a generous overlap for double protection. Shoulder pads included. Also available without wide...
Front protection with choice of adjustable 2" buckle or velcro belt which crosses the back for a comfortable fit. Adjustable straps at shoulders keeps apron snug....
Medicine Products: