Navigation Links
RA Drugs Not Implicated In Cancer

Rheumatoid arthritis (RA) patients have an increased risk of developing lymphoma and leukemia. The autoimmune, inflammatory disease that causes a lot of joint pain does have the risk of cancer. //Researchers speculate that antirheumatic drugs (DMARDs) – including tumor necrosis factor alpha (TNFá) antagonists, a type of biologic DMARD may play a role in this.

TNF blockers, which work by attaching to and impeding chemical messengers behind inflammation, have had a significant impact on the treatment of RA. They have also been linked to lymphoma among users. In fact, reports of lymphoma prompted the Food and Drug Administration to mandate adding a cancer risk warning to the labels of three TNF blockers: etanercept (Enbrel), infliximab (Remicade), and adalimumab (Humira).

Motivated by persistent concerns and inconclusive studies, researchers at Harvard Medical School's Brigham and Women's Hospital set out to investigate the association between treatment with TNF blockers and occurrence of cancer in a large sample of patients with RA. Their results, featured in the September 2006 issue of Arthritis & Rheumatism (http://www.interscience.wiley.com/
journal/arthritis), indicate that biologic DMARD therapy poses no greater risk for cancer than therapy with a standard prescription DMARD, methotrexate (MTX).

The researchers focused on 7,830 RA patients, age 65 and older, drawn from healthcare databases in New Jersey, Pennsylvania, and British Columbia, Canada. Subjects included 1,152 biologic DMARD users and 7,306 MTX users. Of those treated with a biologic DMARD, 64 percent had used etanercept, 33 percent had used infliximab, and the remaining 2 percent had used anakinra (Kineret). 55 percent had previously used MTX and 39 percent were receiving MTX when they began anti-TFN therapy.

Based on medical utilization information, the researchers measured every subject's general health and RA-related characteristics during the 6-mo nth period before exposure to either a biologic DMARD or MTX. In general, biologic DMARD users had more severe RA than MTX users. No subject had a diagnosis of any cancer before starting their prescribed drug treatment. Each subject was followed after beginning use of either a biologic DMARD or MTX, with attention to diagnosis of cancer followed by any course or combination of palliative care, biopsy, radiation, chemotherapy, or surgery. Using time-varying propensity scores to adjust for a wide range of possible factors and stratified proportional hazards regression, researchers estimated the effects of biological DMARDs on cancer.

From their rigorous definition of cancer, researchers identified a total of 11 cancers of the blood and lymphatic systems and 46 cancerous tumors during 2,940 person-years of biologic DMARD use, and 58 cancers of the blood and lymphatic systems and 558 tumors during 30,300 person-years of MTX use. Comparing biologic DMARD users with MTX users, the hazard ratio was 1.37 for blood-related cancers and 0.91 for solid tumors. The overall difference in estimated cancer risk was less than 5 percent between RA patients treated with a TNF blocker and those treated with a standard DMARD.

"We found no significant increase in the risk of cancers in biologic DMARD users," notes the study's lead authors, Soko Setoguchi, M.D. Dr.P.H and Sebastian Schneeweiss, M.D, Sc.D. "Our data indicate that it is unlikely that RA patients who have received biologic agents have a much greater risk of lymphoproliterative disorders, hematologic malignancies, and solid tumors compared with MTX users." Drs, Setoguchi and Schneeweiss, however, acknowledges the challenge of studying the effects of a relatively novel therapy on rare forms of blood cancer, as well as the need for ongoing studies into the risks and benefits associated with anti-TNF therapy.

Source: Eurekalert

Source-Eurekalert
RA
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
3. Nasal Spray Could Take Drugs Direct to Brain.
4. Emphasis to ban Drugs ads by Doctors
5. Osteoporosis Drugs: right time to take-off
6. Drugs disrupt formation of blood vessels
7. Drugs to stop burgeon of HIV
8. Misleading Advertisements for Prescription Drugs
9. Drugs For Anthrax May Interfere With Oral Contraceptives
10. Over-The-Counter Drugs May Prevent Alzheimers
11. Steps To Improve Quality Of Plant-Based Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/21/2017)... ... April 21, 2017 , ... BrightStar Care Salt Lake City, a ... Care of Utah (APCUT) and has appointed Rex Wheeler as its new Director of ... for our agency and our ability to provide quality care to the community,” said ...
(Date:4/21/2017)... ... April 21, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... in hopes of squashing a global crisis with solution to peace plan. Yisrayl says war ... because the plan is given by the Creator Himself. , Yisrayl says war drums ...
(Date:4/21/2017)... ... April 21, 2017 , ... During April 21-23, Super-Sod will join the vendor ... offers entertainment for everyone — from the avid gardener to the landscape admirer — ... quality event held in a grand venue, and we are certainly looking forward to ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... reveals good news for older shoulder replacement patients; post-operative recovery just might be ... two groups of patients presenting with osteoarthritis following surgery: 262 patients under 65 ...
(Date:4/21/2017)... Ireland (PRWEB) , ... April 21, 2017 , ... National ... dramatic increase in the number of bed bug infestations over the 5-year period. In ... companies was from the treatment of bed bug infested properties. , The health and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), ... Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Executive Officer of the Company is scheduled to present on Tuesday, ... and the Chairman of the Board, Tony Holler ... ...
(Date:4/19/2017)... 2017 Global Surgical Drainage Device Market: Overview ... to remove excess liquid and air. The fluid to ... or lymph. Surgical drains are used in a wide ... surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. Common use ... accumulation of fluid e.g. blood or pus. Surgical drains ...
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
Breaking Medicine Technology: