( Cumulative 20-year AF incidence ra...)Pulse Pressure Identified as Important Risk Factor for Atrial Fibrillation,Health

Cumulative 20-year AF incidence rates were 5.6 percent for pulse pressure of 40 mm Hg or less (25th percentile) and 23.3 percent for pulse pressure greater than 61 mm Hg (75th percentile).

"In summary, we have shown that increased pulse pressure, a simple and readily accessible if somewhat indirect measure of arterial stiffness, is likely an important risk factor for development of AF in a community-based sample. Arterial stiffness increases with advancing age, even in a relatively healthy sample. However, increased arterial stiffness with advancing age is not inevitable and appears to be modifiable [such as by reducing various cardiovascular disease risk factors]. As a result, increased arterial stiffness may represent a major modifiable risk factor for development of AF."

"Given the aging of the population, further research is needed to determine whether interventions aimed at reducing pulse pressure or preventing the increase in pulse pressure with advancing age effectively reduce the incidence of AF. In light of the variable and often substantial increase in pulse pressure that accompanies advancing age, lifestyle modifications or therapy aimed specifically at reducing or limiting the increase in pulse pressure with advancing age may markedly reduce the substantial and rapidly growing incidence of AF in our aging society," the authors write.

Source-Eurekalert
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