Navigation Links
Proteins in Microparticles Identified in Women With Preeclampsia

Proteins released by the placenta may damage blood vessels in women with preeclampsia (PE).//

In PE, a complication of pregnancy linked to life-threatening increases in high blood pressure after 20 weeks of gestation, it has long been recognized that substances called "microparticles" released by the placenta damage maternal blood vessels. Researchers at Yale School of Medicine, led by Seth Guller, sought to detect whether specific proteins were found in microparticles.

The team, including researchers from Berne, Switzerland, studied placentas obtained from patients with preeclampsia who had uncomplicated pregnancies delivered at term by cesarean section.

They found that microparticles released from the placenta contain a protein that regulates clot formation (plasminogen activator inhibitor-1). They also found that microparticles contain soluble Flt-1, which inhibits blood vessel growth, and that microparticles contain extremely high levels of plasminogen activator inhibitor-2, a placental protein with no known function.

"In this study, we demonstrate for the first time that microparticles released by the placenta may contain factors that damage maternal blood vessels in preeclampsia," said Guller, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences.

Guller said for this study, the team only detected whether specific proteins were found in microparticles. "In the future, we will determine whether they are biologically active—promote damage in vessel culture models—and whether they are present in the blood of women with preeclampsia," said Guller.



Source-Eurekalert
PR
'"/>




Page: 1

Related medicine news :

1. Levels Of Blood Proteins May Help Heart Disease Care
2. Cholesterol can be lowered using combination of Soy Proteins and Sterols
3. Neurological Disorders Overcome By Proteins
4. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
5. NR2B Proteins Lead To Chronic Pain
6. Methyl-DNA binding Proteins To Fight Cancer
7. Ape Humans? Alterations in Proteins Affects Genes.
8. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
9. Blood Clotting Disorders Linked To Three Proteins
10. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... NY (PRWEB) , ... May 27, 2016 , ... Aimed ... inspiring human interest stories, which come courtesy of leaders in the nursing and health ... industry, from leading advocates and associations—namely Abilene Christian University. , As the nursing ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... Despite last ... meeting, expect Janet Yellen and company to wait until March 2017 for an interest ... University’s J. Mack Robinson College of Business. , “The Federal Open Market Committee (FOMC) ...
(Date:5/26/2016)... ... 2016 , ... Cabot Corporation, Pfizer, and 3M are responsible ... documents and SEC filings. A jury has returned a verdict of $32.8 ... Case No. BC588866, Los Angeles County, California. The jury awarded $22.8 million in ...
(Date:5/26/2016)... ... 2016 , ... Connor Sports, through its Connor Cares initiative, will ... Tamika Catchings Legacy Tour that will commemorate the Indiana Fever legend’s hall-of-fame career ... all forms and levels of the game, Connor Sports has committed to a significantly ...
(Date:5/26/2016)... Pittsburgh, PA (PRWEB) , ... May 26, 2016 ... ... transplantation, and one that has a significant negative impact on long-term patient survival, ... to date. The results, published online this week in the Journal of Thoracic ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... instances of hypertension is driving ambulatory blood pressure monitoring ... their elasticity and their ability to respond to different ... This condition can lead to various cardiovascular disorders such ... vascular disease. These diseases are growing in prevalence each ...
(Date:5/27/2016)... FRANCISCO , May 27, 2016 ... company focused on developing products for Regenerative Medicine, Neurology and Orphan ... will be presenting at two upcoming investor conferences: ... Center, 730 Third Avenue, New York City , ... 3:00pm Marcum MicroCap Conference   Where: ...
(Date:5/26/2016)... 26, 2016 A key trend ... the emergence of new treatments. Cardax, a development stage ... treatment. The therapy is expected to fulfil large unmet ... is conducting studies to develop new treatments for osteoarthritis. ... genes involved in osteoarthritis are being investigated, and early ...
Breaking Medicine Technology: