Navigation Links
Protein’s role in regulating cell death sets direction for Alzheimer’s, Parkinson’s and cancer reseach

A protein called calpain can play a key role in regulating cell death, a Queen’s University study has found. Proof has been raised by these scientists //that calpain may be used to promote cell death in cancer cells but can be directed to prevent cell death such as in neuronal cells in the case of Alzheimer’s or Parkinson’s.

Dr. Greer is a Professor of Pathology and Molecular Medicine with the Cancer Biology and Genetics division of Queen’s University’s Cancer Research Institute. 'All cells in our body have the ability to trigger an intrinsic programmed cell death response. In the case of nerve cells that have been temporarily cut off from their oxygen supply because of a stroke, or damaged by amyloid deposits, this might seem like a bad thing that could contribute to neurodegenerative disease,' says Dr. Greer who produced the study with Yinfei Tan, Nathalie Dourdin, Chao Wu, Teresa De Veyra, and John S. Elce.'On the other hand, when a cell's chromosomes are damaged by carcinogens or ultraviolet light in a way that could initiate cancer, this same programmed cell death response could save your life.'

Supported by an operating grant from the Canadian Institute of Health Research the first study, now published online and to appear in print on June 9, showed that calpain promoted programmed cell death after cells were damaged by chemicals that disrupt the endoplasmic reticulum, which is a major synthetic structure in the cell that controls the synthesis and distribution of new proteins.

In the second study, now published in JBC online, Dr. Greer and co-investigators Yinfei Tan, Chao Wu, and Teresa De Veyra, found that calpain also inhibits programmed cell death in response to other challenges, including some chemotherapeutic drugs.

This study showed that calpain contributes to the activation of AKT and JNK, two key players in the signaling pathways that control cellular responses to different death stimuli. These discov
'"/>




Page: 1 2

Related medicine news :

1. Brain death – How to cope with it
2. Fireworks can spell death for asthmatic children
3. Nearly all asthma deaths preventable
4. Avoid sudden death by quick cooling
5. Negligent doctors asked to cough up 3 lakhs for death of patient
6. Increase in tobacco deaths
7. Aspirin reduces deaths
8. Almost a death experience
9. Unnatural death common in mentally ill
10. Immunisation to prevent cot deaths
11. Lower surgical volume linked to higher death rate
Post Your Comments:
(Date:8/1/2014)... (GSA) the nation,s largest interdisciplinary organization devoted ... J. Jill Suitor, PhD, of Purdue University as ... to Gerontology Award. , This distinguished honor is ... have helped bring about a new synthesis and ... designs addressing a significant problem in the literature. ...
(Date:8/1/2014)... Gerontological Society of America (GSA) the ... aging has chosen Sean P. Curran, PhD, of ... of the Nathan Shock New Investigator Award. , This ... knowledge about aging through basic biological research. It was ... founding member of GSA and pioneer in gerontological research ...
(Date:8/1/2014)... Gerontological Society of America (GSA) the ... aging has chosen Carole B. Lewis, PT, DPT, ... recipient of the Excellence in Rehabilitation of Aging Persons ... acknowledge outstanding contributions in the field of rehabilitation. The ... or patient care, or publications that may include scholarly ...
(Date:8/1/2014)... Lifeinsurancenomedicalexam.info has released a new blog post explaining ... high cholesterol levels. , Clients who have a ... medical exam life insurance. These plans offer a convenient ... Since there are no medical examinations involved, clients who ... a few minutes. However, this convenience comes at a ...
(Date:8/1/2014)... August 01, 2014 Chilton Medical ... that aims to empower patients and their families ... health care by providing easy, secure access to ... patients instant, web-based access to their health information ... results, medications, allergies, demographic information, visit history, discharge/aftercare ...
Breaking Medicine News(10 mins):Health News:Suitor to receive GSA's 2014 Distinguished Career Contribution to Gerontology Award 2Health News:Curran to receive GSA's 2014 Nathan Shock New Investigator Award 2Health News:Lewis to receive GSA's 2014 Excellence in Rehabilitation of Aging Persons Award 2Health News:No Exam Life Insurance - Coverage for Clients Who Have High Cholesterol 2Health News:Chilton Medical Center Launches Online Patient Portal 2
... new project is an interdisciplinary research project covering ... has been awarded EUR 6 million from the ... The project will gather scientists from seven countries, ... University of Gothenburg, Sweden. , Those working on ...
... In the rat race of life, one thing is certain: ... in Molecular Ecology finds the same is true ... most form distinct neighborhoods where they spend the majority of ... lively neighborhoods each with its own personality. But scientists ...
... by Erich Lindemann Community Mental Health Education Center Initiative ... of Professional Psychology BOSTON, May 26 "The ... the needs of 1.5 million soldiers and marines and ... Estimates are as high as 33% that these ...
... connect using technology powered by 100 percent ... N.Y., May 26 Optimum Lightpath, a ... New York metropolitan area businesses, today introduced ... available exclusively through Optimum Lightpath to New ...
... Novel Oral Therapies Will Garner 29 Percent of the ... from Decision ResourcesWALTHAM, Mass., May 26 Decision Resources, ... for pharmaceutical and healthcare issues, finds that the approval ... as the increasing use of current and emerging injectable ...
... helps explain association between the two illnesses , , TUESDAY, ... gum disease (periodontitis) and heart disease has been discovered ... coronary heart disease (CHD) has been known for years, ... confirmed. The University of Kiel team found that the ...
Cached Medicine News:Health News:Sahlgrenska Academy to lead major European project on obesity 2Health News:Returning War Veterans: Challenges in Continuing Mental Health Care After Military and Civilian Trauma 2Health News:Returning War Veterans: Challenges in Continuing Mental Health Care After Military and Civilian Trauma 3Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 2Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 3Health News:Optimum Lightpath(SM) and GetWellNetwork(R) Transform Hospital Bedside Care with Launch of Interactive Patient Care Service 4Health News:Launch of Highly Anticipated Oral Agents and Increasing Use of Current and Emerging Injectable Drugs Will Drive the Multiple Sclerosis Drug Market to Nearly $10 Billion in 2018 2Health News:Launch of Highly Anticipated Oral Agents and Increasing Use of Current and Emerging Injectable Drugs Will Drive the Multiple Sclerosis Drug Market to Nearly $10 Billion in 2018 3Health News:Gum Disease, Heart Disease Share Genetic Link 2
(Date:7/31/2014)... , July 31, 2014 Lazarus Effect, ... novel interventional devices to facilitate removal of blood clots, ... from the financing will support EU commercialization of several ... for the Lazarus ReCover™ and Lazarus Cover™ in ... financing reflects investor confidence in the value of our ...
(Date:7/31/2014)... Catylix, Inc. ( Burbank, California ... California ) announced today the formation of ... fluorination products and related chemistry. Developing ... use of substituents that are chemically stable, resistant ... improve binding and bioavailability. Fluorinated functional groups are ...
(Date:7/31/2014)... -- Zacks.com announces the list of stocks featured in the Analyst ... latest news and events impacting stocks and the financial markets. ... BIIB - Free Report ), Gilead (Nasdaq: GILD - ... Report ), AbbVie (NYSE: ABBV - Free Report ) ... Today, Zacks is promoting its ,Buy, stock recommendations. ...
Breaking Medicine Technology:Lazarus Effect Closes $5 Million Financing 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 2The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 3The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 4The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 5The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 6
... Phase III,clinical trial evaluating the efficacy and safety ... of postmenopausal osteoporosis were,presented at the American Society ... In the non-inferiority study comparing risedronate 150,mg once ... sodium,tablets)] increases in bone mineral density (BMD) were ...
... Sept. 19 Rockwell Medical,Technologies, Inc. (Nasdaq: ... and,developer of concentrates and specialty pharmaceuticals focused ... that it has commenced,enrollment in its Phase ... a physiological iron-maintenance therapy drug. The ...
Cached Medicine Technology:New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis 2New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis 3New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis 4New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis 5New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis 6Rockwell Medical Technologies, Inc. Begins Patient Enrollment for its SFP Dose-Ranging Study 2Rockwell Medical Technologies, Inc. Begins Patient Enrollment for its SFP Dose-Ranging Study 3Rockwell Medical Technologies, Inc. Begins Patient Enrollment for its SFP Dose-Ranging Study 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: