Navigation Links
Protein’s role in regulating cell death sets direction for Alzheimer’s, Parkinson’s and cancer reseach

A protein called calpain can play a key role in regulating cell death, a Queen’s University study has found. Proof has been raised by these scientists //that calpain may be used to promote cell death in cancer cells but can be directed to prevent cell death such as in neuronal cells in the case of Alzheimer’s or Parkinson’s.

Dr. Greer is a Professor of Pathology and Molecular Medicine with the Cancer Biology and Genetics division of Queen’s University’s Cancer Research Institute. 'All cells in our body have the ability to trigger an intrinsic programmed cell death response. In the case of nerve cells that have been temporarily cut off from their oxygen supply because of a stroke, or damaged by amyloid deposits, this might seem like a bad thing that could contribute to neurodegenerative disease,' says Dr. Greer who produced the study with Yinfei Tan, Nathalie Dourdin, Chao Wu, Teresa De Veyra, and John S. Elce.'On the other hand, when a cell's chromosomes are damaged by carcinogens or ultraviolet light in a way that could initiate cancer, this same programmed cell death response could save your life.'

Supported by an operating grant from the Canadian Institute of Health Research the first study, now published online and to appear in print on June 9, showed that calpain promoted programmed cell death after cells were damaged by chemicals that disrupt the endoplasmic reticulum, which is a major synthetic structure in the cell that controls the synthesis and distribution of new proteins.

In the second study, now published in JBC online, Dr. Greer and co-investigators Yinfei Tan, Chao Wu, and Teresa De Veyra, found that calpain also inhibits programmed cell death in response to other challenges, including some chemotherapeutic drugs.

This study showed that calpain contributes to the activation of AKT and JNK, two key players in the signaling pathways that control cellular responses to different death stimuli. These discov eries suggest that calpain inhibitors might improve the ability of chemotherapeutic drugs or radiation treatment to specifically kill tumour cells in cancer patients.

(source:eurekalet)
'"/>




Related medicine news :

1. Brain death – How to cope with it
2. Fireworks can spell death for asthmatic children
3. Nearly all asthma deaths preventable
4. Avoid sudden death by quick cooling
5. Negligent doctors asked to cough up 3 lakhs for death of patient
6. Increase in tobacco deaths
7. Aspirin reduces deaths
8. Almost a death experience
9. Unnatural death common in mentally ill
10. Immunisation to prevent cot deaths
11. Lower surgical volume linked to higher death rate
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... PASADENA, CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. ... he would lash out at his family verbally and physically. , “When something upset him, ... table, he would use it. He would throw rocks at my other children and say ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... actively feeding the Frederick area economy by obtaining investment capital for emerging technology ... past 2½ years that have already resulted in more than a million dollars ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
Breaking Medicine Technology: