Navigation Links
Protein acts as "Master Switch" that cuts off cells' Cancer-Growth machinery

A Washington University research team headed by Shrikant Anant, PhD, is mighty excited about their new discovery that was reported in the journal, Molecular Cell. They have found a "master switch" - a protein named CUBGP2(cytidine-uridine-guanosine binding protein) - that makes cancer cells self-destruct. The findings that were published// apply only to cancer cells grown in a test tube. Human studies aren't yet on the drawing board. However, lead researcher Anant said that the protein works across the board for many cancers and that it might become a great tool for cancer therapy.

CUBGP2 has multiple effects but there is one very important effect that stands out from the rest. All normal cells are full of CUBGP2 and when their time comes to die, this protein helps them do so by activating their built-in self-destruct program. But, when these cells start becoming cancerous, they somehow lose CUBGP2 and this leads to build up of large amounts of an enzyme known as Cox-2. Cox-2 is the major culprit in arthritis and headache. Aspirin-like drugs and newer drugs such as Celebrex and Vioxx, known as Cox-2-selective inhibitors, block the action of this enzyme. Cox-2, when over-expressed by precancer cells, helps them grow the new blood vessels they need to become tumors.

Aspirins and the new Cox-2 inhibitors help slow cancer growth, but they have a limited effect. However, when Anant's team put CUGBP2 into cancer cells, they found that more than 70% of them died and the protein also shut off the Cox-2 gene. Anant's colleague Brian K. Dieckgraefe (pronounced de-GRAF) said that this might be an important therapeutic advance and might lead to a considerable amount of new research into a pathway that may have dramatic anticancer effects.


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein acts Master Switch that cuts off cells Cancer Growth machinery

(Date:12/17/2014)... 17, 2014 This prestigious award ... that have made outstanding and innovative contributions to ... progression of private practice physical therapy by the ... Association. , On behalf of Performance Physical Therapy, ... CEO of Performance accepted the award at the ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 Now in ... celebrate the best of the best in senior living ... is only given to communities and agencies that have ... SeniorAdvisor.com site. Of the nearly 100,000 providers currently listed ... Winners of the SeniorAdvisor.com Best of 2015 Awards are ...
(Date:12/17/2014)... -- Poor students get more fruits and vegetables at school ... But, the opposite is true for students from wealthier families. ... school may give a healthy boost to poor students, diets, ... family income level, students all ate a similar amount of ... study was published recently in the journal Preventive Medicine ...
(Date:12/15/2014)... December 15, 2014 A recent survey ... States women as impacting skin health and beauty were: ... of skin care.” Water and health advocate and radio ... recent article describing the survey and the Four C’s.* ... in every category discussed would benefit from paying attention ...
(Date:12/15/2014)... SIMpalm, a leading mobile app ... iPhone for its client, which allows users to keep ... specialized in finding the right wine. At the ... combined sensory, chemistry and wine information. All this information ... fingerprint.” Those wines that are close counterparts to one ...
Breaking Medicine News(10 mins):Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 2Health News:The Inn at Willow Falls - Crest Hill, IL Wins 2015 Best of Assisted Living Award from SeniorAdvisor.com 3Health News:Poor Students Eat Healthier Foods at School, Study Finds 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 2Health News:Water and health advocate Sharon Kleyne adds a “W” for fresh water to “four C’s of skin care” 3Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2
... decided to prepone the Japanese Encephalitis immunisation drive. This has ... they feel that it might not be he right time ... has been decided that the immunisation campaign scheduled to take ... 15, 2006 itself. 5.2 million doses of the Chinese made ...
... method to aid the formation of insulin crystals in ... University of Houston professor and his student, which holds ... // ,Peter Vekilov, associate professor of chemical ... chemical engineering, both in UH's Cullen College of Engineering, ...
... awakening to the growing menace of the drug problem, reports ... ,In order to effectively deal with the problem, police ... openly and stressing on the adverse effects of drugs like ... officials and religious leaders were stressing on the need to ...
... increased risk of fractures in later life, particularly during ... The Children's Hospital of Philadelphia and other researchers analysed ... had first experienced arthritis between ages one and 19. ... larger control group of 207,000 patients in a primary ...
... a recent study, women who use the contraceptive pill, ... risk of developing depression//. ,Adverse Psychiatric Reactions Information ... an effective contraceptive licensed as a hormone treatment for ... ,The women said they experienced serious depression ...
... states with urban states getting more for their premium ... (1-9 workers) pay an average 18% more in health ... workers), when actuarial value--the percentage of total medical expenses ... new Commonwealth Fund-supported study finds. ,In this ...
Cached Medicine News:Health News:Uttar Pradesh To Prepone The Japanese Encephalitis Immunisation Drive 2Health News:Uttar Pradesh To Prepone The Japanese Encephalitis Immunisation Drive 3Health News:Insulin Crystals Holds Promise In Diabetes research 2Health News:Health Insurance Plans Varies among States 2Health News:Health Insurance Plans Varies among States 3
(Date:12/15/2014)... 15, 2014 BerGenBio AS, a ... drug resistant cancers, today announces that it has raised ... from new and existing investors. BerGenBio will ... development of its pipeline of innovative cancer therapeutics, in ... drug candidate, BGB324, a first-in-class selective Axl kinase inhibitor, ...
(Date:12/15/2014)... N.J. , Dec. 15, 2014   Regeneron ... and NYSE: SNY) are collaborating with nationally-recognized patient and ... , an awareness program that will gauge how much ... associated with high LDL-C (bad cholesterol).  American adults are ... take a brief poll and answer a few key ...
(Date:12/15/2014)... FRESH MEADOWS, N.Y. , Dec. 15, 2014 /PRNewswire/ ... using the SPL (Structured Product Labeling) markup language standard, ... need the understanding and skills to work with the ... present a series of three webinars on the benefits ... The three one-hour webinars will be facilitated by ...
Breaking Medicine Technology:BerGenBio Completes NOK90 Million Fundraising 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 2Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 3Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 4Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 5Have You Been Counted? Regeneron and Sanofi US Join Forces with Leading Cardiovascular Organizations to Raise Awareness of Cholesterol 6Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 2Data Conversion Laboratory Helping Life Sciences Content Producers Understand the Impact and Benefits of Structured Product Labeling 3
... 5, 2011 CVS/pharmacy, the nation,s leading retail ... club program for the chain-drug channel during the ... 9 PM EST. The CVS/pharmacy ExtraCare Beauty Club, ... provides ExtraCare® card holders who register their cards ...
... MARIETTA, Ga., Jan. 5, 2011 MiMedx ... an integrated developer, manufacturer and marketer of patent protected ... of Surgical Biologics, a leader in the development of ... of surgical indications from amnion membranes. The deal was ...
Cached Medicine Technology:CVS/pharmacy Launches ExtraCare Beauty Club 2CVS/pharmacy Launches ExtraCare Beauty Club 3MiMedx Completes Acquisition of Surgical Biologics 2MiMedx Completes Acquisition of Surgical Biologics 3MiMedx Completes Acquisition of Surgical Biologics 4
... TOPCON Trial Lens Set offers ... powers, featuring special corrected curve ... thickness and air spacing between ... exact correction to be read ...
... The AIT-8Bs instrument design ... The table is fully wheelchair ... loads up to 100 lbs. ... for Topcon retinal camera units ...
This isnt just another new stand weve come up with, this is absolutely revolutionary!...
The LM-990A is the most completely automatic lensemeter ever created. It even measured monocular and binocular PD automatically....
Medicine Products: