Navigation Links
Protein That Absorbs Lipids may Provide Future Weight-loss Strategies

A study conducted by researchers at Washington University School of Medicine in St. Louis has led to the identification of a protein that absorbs lipids in the upper part of the intestine, raising hopes that it may provide a novel approach for obesity treatment in the future.

Principal investigator Dr. Nada A. Abumrad, the Dr. Robert C. Atkins Professor of Medicine and Obesity Research at Washington University School of Medicine, first identified CD36 protein that facilitates the uptake of fatty acids. The protein is located on the surface of cells and distributed in many tissues, including fat cells, the digestive tract, heart tissue and skeletal muscle tissue.

Dr. Abumrad says that the intestine makes large amounts of CD36, and that it is important to the absorption of fatty acids.

During her initial experiments, wherein she compared normal mice that made the protein to genetically altered mice lacking the protein, she could not find any net difference in their fat absorption. In the present study, the researcher has found the reason why it was not possible to identify a difference.

She says that CD36 normally absorbs fatty acids in the upper, or proximal part of the intestine, but in its absence, lower, more distal, sections of the intestine compensate and absorb the fat.

"We think of the intestine as a single organ, but it's really made up of distinct areas that are so specialized it's almost like several organs. The fat that is not absorbed in the proximal areas ends up being bumped into the distal intestine where different systems absorb it," Abumrad says.

The researchers believe that targeting the upper part of the intestine and interfering with normal CD36 function may be a useful tool in weight loss. They say that animals that cannot make CD36 absorb fat less efficiently, due to which they tend to eat less of it.

"And the most exciting part for us right now is the fact that these things may apply to humans. Humans with mutations in the gene that makes CD36 don't seem to process fat normally either," Abumrad says.

The researcher further said that her goal was to determine the same the findings of mice studies into humans, where variations in the CD36 gene are common. She, however, admitted that before so doing, she wanted to learn more from animal studies.

"There is evidence that people have different amounts of CD36 and that mutations in the gene are quite common," she said.

"Those variations are associated with abnormalities of blood lipids, with high levels of fatty acids in the blood, abnormal blood triglycerides and increased risk of diabetes-associated heart disease. It's clear that some of us have different amounts of this protein in different tissues, and some individuals don't have any of it," she added.

The study has been published in the Journal of Biological Chemistry.


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... , ... October 12, 2017 , ... ... services for healthcare compliance program management, will showcase a range of technology and ... for Assisted Living (NCAL) Convention and Expo to be held October 14–18, 2017 ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
(Date:10/12/2017)... PA (PRWEB) , ... October 12, 2017 , ... ... is the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B ... York City on October 11, 2017. , The annual award competition recognizes editorial and ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: