Navigation Links
Protein That Absorbs Lipids may Provide Future Weight-loss Strategies

A study conducted by researchers at Washington University School of Medicine in St. Louis has led to the identification of a protein that absorbs lipids in the upper part of the intestine, raising hopes that it may provide a novel approach for obesity treatment in the future.

Principal investigator Dr. Nada A. Abumrad, the Dr. Robert C. Atkins Professor of Medicine and Obesity Research at Washington University School of Medicine, first identified CD36 protein that facilitates the uptake of fatty acids. The protein is located on the surface of cells and distributed in many tissues, including fat cells, the digestive tract, heart tissue and skeletal muscle tissue.

Dr. Abumrad says that the intestine makes large amounts of CD36, and that it is important to the absorption of fatty acids.

During her initial experiments, wherein she compared normal mice that made the protein to genetically altered mice lacking the protein, she could not find any net difference in their fat absorption. In the present study, the researcher has found the reason why it was not possible to identify a difference.

She says that CD36 normally absorbs fatty acids in the upper, or proximal part of the intestine, but in its absence, lower, more distal, sections of the intestine compensate and absorb the fat.

"We think of the intestine as a single organ, but it's really made up of distinct areas that are so specialized it's almost like several organs. The fat that is not absorbed in the proximal areas ends up being bumped into the distal intestine where different systems absorb it," Abumrad says.

The researchers believe that targeting the upper part of the intestine and interfering with normal CD36 function may be a useful tool in weight loss. They say that animals that cannot make CD36 absorb fat less efficiently, due to which they tend to eat less of it.

"And the most exciting part for us right now is the fact that these things may apply to humans. Humans with mutations in the gene that makes CD36 don't seem to process fat normally either," Abumrad says.

The researcher further said that her goal was to determine the same the findings of mice studies into humans, where variations in the CD36 gene are common. She, however, admitted that before so doing, she wanted to learn more from animal studies.

"There is evidence that people have different amounts of CD36 and that mutations in the gene are quite common," she said.

"Those variations are associated with abnormalities of blood lipids, with high levels of fatty acids in the blood, abnormal blood triglycerides and increased risk of diabetes-associated heart disease. It's clear that some of us have different amounts of this protein in different tissues, and some individuals don't have any of it," she added.

The study has been published in the Journal of Biological Chemistry.


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... Southland ... line of classic American timber frame barn kits, which can be found on its ... inspired by historic American barn plans, and they highlight the craftsmanship of timber post ...
(Date:5/27/2016)... ... May 27, 2016 , ... With over 60 percent of acute stroke survivors ... sustainable product to aid in the rehabilitation process has steadily increased. Ekso Bionics had ... with hemiplegia due to stroke. , Ekso Bionics has now received clearance from the ...
(Date:5/27/2016)... ... May 27, 2016 , ... Beleza Medspa has initiated a new ... This is the first time that Coolsculpting is being used for for more than ... to ensure they meet the prescribed body-fat standard, measured by the circumference-based tape method. ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team of ... food industries. Aside from its GMP accreditation, Validation Center is also a registered ... products, services and staff. , Validation Center is ISO17025 accredited and only offers ...
(Date:5/26/2016)... ... May 26, 2016 , ... Cabot Corporation, Pfizer, and ... according to court documents and SEC filings. A jury has returned a ... American Optical Corporation, Case No. BC588866, Los Angeles County, California. The jury awarded ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... --   , Study met ... cleansing and superiority in , Excellent ... of the ascending colon   , ... Norgine B.V. today announced new positive data from the phase III ... versus standard 2 litre PEG with ascorbate. The study met both ...
(Date:5/24/2016)... Zealand , May 24, 2016 ... informatics solutions for the healthcare sector, has been named the ... Zealand Hi-Tech Awards 2016. Dr Bruce Davey ... acknowledgement for our team.  It,s really good to be recognised ... healthcare internationally. Our products are used in 35 countries around ...
(Date:5/24/2016)... , May 24, 2016 Celsion ... drug development company, today provided an update on ... escalating clinical trial combining GEN-1, the Company,s DNA-based ... treatment of newly-diagnosed patients with advanced ovarian cancer ... debulking surgery.  GEN-1 is an IL-12 DNA plasmid ...
Breaking Medicine Technology: