Navigation Links
Protein Structure of Pathogens Associated With CF and TB Solved

The structure of a novel protein in the bacterium that is the most persistent pathogen in cystic fibrosis (CF) patients has been solved .

Hauptman-Woodward Institute scientists Dr. Andrew Gulick, Eric Drake and Dr. Manish Shah, in collaboration with researchers at the University at Buffalo and the New York State Center of Excellence in Bioinformatics and Life Sciences have made this significant discovery which was published in the current issue of the Journal of Biological Chemistry.

The study is the first structural characterization of this novel protein that is present in many bacteria including the pathogen that causes tuberculosis.It's well-known that bacteria need iron to grow and, when they are establishing an infection, they steal iron from the host.

To do this, they make complex molecules that bind tightly to the iron. We have determined the structure of a protein that is essential to produce normal amounts of one of these complex molecules in Pseudomonas. What is interesting is that other bacteria use a very similar protein and we assume the proteins will be essential there as well.

This work gives us clues to the role of this protein and we hope that future studies will identify the precise role that may provide an opportunity to disable this protein and may identify a new antibiotic that could limit the infections that can be fatal in CF patients, Gulick said.

Work from other labs has identified the proteins that are essential to make pyoverdine, the compound that Pseudomonas produces to obtain iron. Some of these proteins are essential, yet the role they play is unknown. The Gulick lab has determined the molecular structure of PA2412, one of these uncharacterized proteins.

The structure of this protein molecule is unlike any previously characterized protein and the lab is now performing additional studies that will more completely identify the role and hopefully ways that the activity can be blocked.

"This is a perfect example of the work my lab enjoys doing. We determine structures and functions of important proteins and provide insights into ways that these proteins can be modulated to improve human health. My lab, like several others at HWI, is most interested in human pathogens and learning new ways that we can block infections by these nasty bugs," Gulick said.

He added that the research was enhanced by the HWI groups collaboration with Dr. Jun Qu, research assistant professor, Dr. Robert M. Straubinger, professor, both in UB School of Pharmacy and Pharmaceutical Sciences and Dr. Jin Cao, research scientist in the UB Center of Excellence.

For more information, visit HWIs website at www.hwi.buffalo.edu or call 716-898-8600.


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes ... important health care topics including advance care planning, healthcare costs and patient and ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/24/2016)... ... 24, 2016 , ... Those who have experienced traumatic events may suffer from ... avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid this ... coping following a traumatic event. , Trauma sufferers tend to feel a range of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, ... treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including robotic ... osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
Breaking Medicine Technology: