Navigation Links
Protein Structure of Pathogens Associated With CF and TB Solved

The structure of a novel protein in the bacterium that is the most persistent pathogen in cystic fibrosis (CF) patients has been solved .

Hauptman-Woodward Institute scientists Dr. Andrew Gulick, Eric Drake and Dr. Manish Shah, in collaboration with researchers at the University at Buffalo and the New York State Center of Excellence in Bioinformatics and Life Sciences have made this significant discovery which was published in the current issue of the Journal of Biological Chemistry.

The study is the first structural characterization of this novel protein that is present in many bacteria including the pathogen that causes tuberculosis.It's well-known that bacteria need iron to grow and, when they are establishing an infection, they steal iron from the host.

To do this, they make complex molecules that bind tightly to the iron. We have determined the structure of a protein that is essential to produce normal amounts of one of these complex molecules in Pseudomonas. What is interesting is that other bacteria use a very similar protein and we assume the proteins will be essential there as well.

This work gives us clues to the role of this protein and we hope that future studies will identify the precise role that may provide an opportunity to disable this protein and may identify a new antibiotic that could limit the infections that can be fatal in CF patients, Gulick said.

Work from other labs has identified the proteins that are essential to make pyoverdine, the compound that Pseudomonas produces to obtain iron. Some of these proteins are essential, yet the role they play is unknown. The Gulick lab has determined the molecular structure of PA2412, one of these uncharacterized proteins.

The structure of this protein molecule is unlike any previously characterized protein and the lab is now performing additional studies that will more completely identify the role and hopefully ways that the activity can be blocked.

"This is a perfect example of the work my lab enjoys doing. We determine structures and functions of important proteins and provide insights into ways that these proteins can be modulated to improve human health. My lab, like several others at HWI, is most interested in human pathogens and learning new ways that we can block infections by these nasty bugs," Gulick said.

He added that the research was enhanced by the HWI groups collaboration with Dr. Jun Qu, research assistant professor, Dr. Robert M. Straubinger, professor, both in UB School of Pharmacy and Pharmaceutical Sciences and Dr. Jin Cao, research scientist in the UB Center of Excellence.

For more information, visit HWIs website at www.hwi.buffalo.edu or call 716-898-8600.


'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... advisory organization, welcomes S.S. Nesbitt as the latest addition to its growing list ... seven other locations throughout the Southeast, from Orlando to Huntsville and in between. ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... award winner and inspirational speaker Jan Fox will serve as keynote speaker at ... will provide participants with tools to more effectively communicate with their own organizational ...
(Date:2/10/2016)... ... February 10, 2016 , ... The ... been awarded the prestigious Distinguished Emerald Club of the World award, as determined ... magazine, one of the most respected trade publications serving private clubs. , “We’d ...
(Date:2/10/2016)... ... February 10, 2016 , ... Workrite Ergonomics this week ... series of monitor mounts ever. , “Our goal was to develop a product ... install system that we have ever created.” said Darren Hulsey, Product Manager for Workrite ...
(Date:2/10/2016)... ... 2016 , ... A new leadership team for Mid-South Youth Camp, operated by ... the announcement Monday night, Feb. 8, prior to the evening session of the university’s ... creator of GO! Camp, has been named director. Gayle McDonald, currently the assistant director ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Feb. 10, 2016  Silicon Biosystems Menarini Inc., ... that help uncover the biological complexities of disease ... a developer of innovative technologies for genomics research, ... aimed at enabling translational researchers to obtain high-quality ... hundred tumor and normal cells in an optimized ...
(Date:2/10/2016)... India , February 10, 2016 ... a new market research report "Pharmaceutical Packaging Equipment Market ... Wrapping, Labeling & Serialization), by Product Type (Tablet, Powder, ... 2020", published by MarketsandMarkets, studies the global market during the ... expected to grow at a CAGR of 6.9% during ...
(Date:2/10/2016)... Feb. 9, 2016 On Tuesday, ... (FDA) met with its Arthritis Advisory Committee ... of Johnson & Johnson,s Remicade and most ... in the U.S. The Biologics Prescribers Collaborative ... - Alliance for Patient Access, American Association ...
Breaking Medicine Technology: