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Protein Splicing Upsets the DNA Colinearity Paradigm

ecognition and destruction by CD8+ T lymphocytes. However, the Belgium/USA team has found that proteasomes can also splice the peptide fragments together in a reverse order to that encoded by the protein’s DNA sequence template. This takes the possible number of antigens from any one protein into potentially thousands of sequence configurations.

The sequence of the first human cancer-specific antigen, which was identified at the LICR Brussels Branch, has allowed the development of antigen-specific cancer vaccines that are in clinical trials around the world. This study describes a mechanism that significantly extends the number of antigenic peptides that can be produced from a single protein, and therefore widens the applicability of peptide vaccines against cancer and infectious diseases.

The Ludwig Institute for Cancer Research (LICR) is the largest international not-for-profit institute dedicated to understanding and controlling cancer. With nine Research Branches and one Centre for Clinical Sciences in seven countries, the scientific network that is LICR quite literally spans the globe. LICR has developed an impressive portfolio of reagents, knowledge, expertise, and intellectual property, and has also assembled the personnel, facilities, and practices necessary to patent, clinically evaluate, license, and thus translate, the most promising aspects of its own laboratory research into cancer therapies.



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