Navigation Links
Protein Markers for Identification of Brain Tumor

Professor Waldemar Debinski and his team from Wake Forest University Baptist Medical Center have found a new treatment for the brain tumor – glioblastoma multiforme. The scientists have found that the inactive form of EphA2 // protein in the brain cells were responsible for spread of cancer cells and the work was published in the Journal Molecular Cancer Research. Glioblastoma multiforme is the most common form of brain tumor and the least curable of all human cancers.

The Protein – EphA2:

Debinski has found a protein EphA2 in large amount in brain tumor patients compared to normal people, but they found that the protein in large amount was in an inactive form. EphA2 protein, which is found in cell membranes, allows normal cells to communicate with their environment and each other. In its normal active state, the protein seems to inhibit abnormal cell growth and division. Debinski found that the inactive form of EphA2 aids in the survival and spread of cancer cells.

Professor tested the treatment hypothesis by treating glioblastoma cells with ephrinA1, a naturally occurring molecule that binds to EphA2 and activates it. They had already demonstrated that ephrinA1 is present at much lower levels in cells and tumors with increased levels of inactive EphA2. The researchers found that cells treated with ephrinA1 slowed down their growth and were less likely to exhibit invasive properties. By changing the levels of EphA2 and ephrinA1 offers new promise for successfully treating glioblastoma multiforme.

Professor Debinski said, “We’ve found that a particular protein may play a major role in the progression of these tumors, suggesting an attractive new treatment approach and the EphA2 represents a novel target for the development of molecular therapeutics for the imaging and treatment of patients with glioblastoma,” Professor added that , “New therapies are clearly needed because, despite the standard treatment of surgically removing the tumor and treating the patient with chemotherapy and radiation, survival has increased only slightly over the past 30 years.”

Earlier Work of Debinski: Interleukin 13 –

Debinski had earlier found that cancer cells had a specific receptor for Interleukin 13 (IL-13), which is a naturally occurring protein that regulates the immune system in the body. Normal cells do not have these same receptors. Debinski developed a drug that combines a form of IL-13 with a toxin that kills cancer cells. By targeting the therapy to these receptors, the drug finds and kills the cancer cells. Debinski has been focusing on identification of new novel molecular markers, which helps in diagnosis of cancer in an early stage.

Source: Newwise.
'"/>




Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2019)... ... 2019 , ... Cibo Vita, Inc., makers of Nature’s Garden, NutriPops, Chocolate Orchard ... indulgence snack line at the 65th annual Summer Fancy Food Show, taking place at ... booth #5721. , The company’s expansive product portfolio features a variety of trail ...
(Date:6/20/2019)... ... , ... Access Healthcare, one of the largest providers of ... appointed as Senior Vice President of Client Services. Angel brings more than 20 ... high performing teams, and driving revenue growth for healthcare companies. , In this ...
(Date:6/19/2019)... (PRWEB) , ... June 19, ... ... from non-governmental organizations, academia, faith-based organizations, private institutions, media, and government joined ... DC to make commitments to improve universal access to water, sanitation, and ...
(Date:6/19/2019)... , ... June 19, 2019 , ... A legal-medical ... the United States, has filed class action lawsuits in 34 of the 48 ... in the class actions are an array of pharmaceutical manufacturers, distributors and retailers, all ...
(Date:6/19/2019)... ... June 19, 2019 , ... Ovation® Fertility scientists have been invited ... Reproduction and Embryology (ESHRE) Annual Meeting in Vienna, June 23-26, 2019. , Ovation’s ... consideration for both the Basic Science Award for Oral Presentation and the Fertility Society ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... ... June 19, 2019 , ... One is never too old to make dreams ... Home (LAJH). Known as a destination for Los Angeles-area seniors, LAJH has an environment ... and Mildred Moccio, it is also a point of embarkation: a place from which ...
(Date:6/19/2019)... ... June 19, 2019 , ... A new survey by The ... $376 per month on healthcare costs. If that doesn’t sound like enough of ... per month, one-in-five survey participants reported spending $1,000 per month or more. The ...
(Date:6/18/2019)... , ... June 18, 2019 , ... ... emergency medicine and hospital medicine management services, are pleased to announce the acquisition ... in Longview, Texas. , LEMA’s 34 physicians and 9 advanced practice clinicians ...
Breaking Medicine Technology: