Navigation Links
Protein Linked To Accelerating Rheumatoid Arthritis

A new study published in the December issue of Arthritis and Rheumatism says that a protein called Type II Collagen (CII) could have a vital role in the pathogenesis of rheumatoid arthritis (RA), a very painful inflammatory // joint condition.

This protein was found by a team of researchers at the Queen Mary's School of Medicine and Dentistry at the University of London. It appears that the protein modifies itself and then proceeds to systematically destroy the body's immune system and concurrently increases inflammation of the joints. These findings could be a pointer towards the development of new drugs to combat the disease.

Type II Collagen (CII) is a major protein found abundantly in cartilage, bone and tendons. The team felt that CII could trigger RA when it is stressed by inflammation. They say that when inflammatory cells enter normal tissue they tend to overuse the oxygen supply. This means that proteins are deprived of this vital element and consequently undergo some modification. To prove this point they took blood samples from 31 male and female RA patients and from 41 patients who had other inflammatory conditions like osteoporosis, back pain and gout. All of these samples were subjected to exposure by CII protein taken from cows as well as a modified CII. This is typically present in rheumatic inflammation. The researchers found that CII did not bind in the blood samples of RA patients. But 45 percent of the RA blood samples formed immune complexes with the altered form of the protein. The researchers say that CII serves to accelerate and already worse condition in RA. "Our study has important implications for the further study and enhanced understanding of the pathology of RA," said study author Ahuva Nissim. "In the future, understanding of this process will help us develop specific therapeutics which will target only the inflamed joints."


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... 05, 2016 , ... Dr. Justin Scott and Dr. Lydia Muccioli of ... Day to individuals in need. The event is scheduled to take place on February ... is to provide dental care to community members in need. Each patient will be ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Ben Amini, ... it is now welcoming orthodontist, Dr. Amanda Cheng, to the practice. With the ... oral health care, including general dentistry, cosmetic treatments, periodontics, implant dentistry , ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the defenses of the day ... feature of patients with eating disorders is significant self-criticism, and consequently these patients experience ... are regarded as maladaptive means for coping with this unease, but also leads to ...
(Date:2/5/2016)... ... 2016 , ... California Mobile Kitchens , a company ... latest mobile kitchen model, featuring customizable stainless steel interiors and a new, 26-foot ... use anywhere in the U.S. Many of their units can be seen at ...
(Date:2/5/2016)... ... ... Calls Blacklist has just been updated by mobile app developer Vlad Lee. The ... known bugs within the app. Calls Blacklist allows its users to only have to ... their device’s battery power or memory. It provides a powerful call blocker that is ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , February 5, 2016 ... Market Research report states that the global active pharmaceuticals ... and is predicted to reach US$185.9 bn by 2020. ... 6.50% from 2014 to 2020. The title of the ... Captive/Contract Manufactured, by Geography, and by Therapeutic Area) - ...
(Date:2/5/2016)... England , February 5, 2016 ... --> Today, VoicePower Ltd - The Speech Recognition People, announced ... been deployed to improve patient care, reduce turnaround times and to ... Wirral CCG ,- VoicePower client since 2013 Challenge: ... Challenge: --> - Six doctors ,- Wirral CCG ...
(Date:2/4/2016)... , Feb. 4, 2016  The Senior Care ... Government Reform Committee Chairman Jason Chaffetz ... holding today,s hearing , "Developments in the ... increases and growing questions about abusive pharmacy benefit ... (R-UT) and Ranking Member Elijah Cummings (D-MD) ...
Breaking Medicine Technology: