Navigation Links
Protein Linked To Accelerating Rheumatoid Arthritis

A new study published in the December issue of Arthritis and Rheumatism says that a protein called Type II Collagen (CII) could have a vital role in the pathogenesis of rheumatoid arthritis (RA), a very painful inflammatory // joint condition.

This protein was found by a team of researchers at the Queen Mary's School of Medicine and Dentistry at the University of London. It appears that the protein modifies itself and then proceeds to systematically destroy the body's immune system and concurrently increases inflammation of the joints. These findings could be a pointer towards the development of new drugs to combat the disease.

Type II Collagen (CII) is a major protein found abundantly in cartilage, bone and tendons. The team felt that CII could trigger RA when it is stressed by inflammation. They say that when inflammatory cells enter normal tissue they tend to overuse the oxygen supply. This means that proteins are deprived of this vital element and consequently undergo some modification. To prove this point they took blood samples from 31 male and female RA patients and from 41 patients who had other inflammatory conditions like osteoporosis, back pain and gout. All of these samples were subjected to exposure by CII protein taken from cows as well as a modified CII. This is typically present in rheumatic inflammation. The researchers found that CII did not bind in the blood samples of RA patients. But 45 percent of the RA blood samples formed immune complexes with the altered form of the protein. The researchers say that CII serves to accelerate and already worse condition in RA. "Our study has important implications for the further study and enhanced understanding of the pathology of RA," said study author Ahuva Nissim. "In the future, understanding of this process will help us develop specific therapeutics which will target only the inflamed joints."


'"/>




Page: 1

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2017)... , ... August 17, 2017 , ... Centrifugation is more ... in the laboratory that we can no longer do without. And just like a ... of your device. , In this webinar, attendees will learn about the most important ...
(Date:8/17/2017)... ... August 17, 2017 , ... A recent report indicates that circa ... in 2016 cited deficiencies in data integrity. The FDA outlines their expectations for quality ... , Presented as part of the Beckman Coulter Life Sciences Virtual Trade Show ...
(Date:8/16/2017)... Bethpage, NY (PRWEB) , ... August 16, 2017 , ... ... Kullen, Long Island’s original family-owned supermarket, has put together suggestions for enjoying the season ... new recipe or activity, everyone in the family can join in on the fun. ...
(Date:8/16/2017)... ... ... Blue Health Intelligence (BHI) announced today that Dr. Alan Spiro ... over 30 years of clinical, healthcare IT, value-based care, and change management experience to ... “I am thrilled to welcome Dr. Spiro to BHI,” said Swati Abbott, CEO of ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... Greenfield Advisors ... companies in the U.S. for the second year in a row. The Inc. 5000 ... past three years. , “To be on the list once is a great accomplishment, ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... 2017   Marshall County Hospital in Benton, Kentucky has ... of hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , short for "total room ... pathogens such as C. diff , MRSA, MERS, Ebola and more. ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
(Date:7/31/2017)... 2017 Three Tru-D SmartUVC robots have arrived at ... . Tru-D, short for "Total Room Ultraviolet Disinfection," is a 5-foot-5 ... environmental services (ES) professional cleans the area with traditional cleaning protocols. ... Tru-D fights germs at ... "Although the BAACH has a very low ...
(Date:7/27/2017)... 27, 2017  West Pharmaceutical Services, Inc. (NYSE: ... the second-quarter 2017 and updated financial guidance for the ... 2017 Highlights Reported net sales of ... prior-year quarter. Net sales at constant currency (organic) grew ... was $0.51, compared to $0.60 in the prior-year quarter. ...
Breaking Medicine Technology: