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Protein Folds Research Offers Insight into Metabolic Evolution

ne and pyrimidine nucleotides that create the core of the RNA molecule.

This discovery supports the hypothesis of an RNA world in which RNA molecules were among the earliest catalysts of life. This idea is based in part on the observation that RNA still retains many of its catalytic capabilities, including the capability to make proteins. Step by step, according to this theory, proteins began taking over some of the original functions of RNA.

The most ancient (protein) molecules were involved in the interconversion of nucleotides. But they were not synthesizing them, Caetano-Anolls said. We see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since these first proteins benefited the formation of building blocks for the primitive RNA world, it makes a lot of sense that weve found this origin encased in nucleotide metabolism.


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