Navigation Links
Protein Folds Research Offers Insight into Metabolic Evolution

Researchers have created the first global family tree of metabolic protein architecture and their advance offers a new window on the evolutionary history of metabolism.

Researchers at the University of Illinois published their work that appears this week in the online edition of the Proceedings of the National Academy of Sciences.

Their work relies on reputable techniques of phylogenetic analysis developed in the past decade to plot the progress of genes and organisms but which have never before been used to work out the evolutionary history of protein architecture across biological networks.

We are interested in how structure evolves, not how organisms evolve, said professor of crop sciences Gustavo Caetano-Anolls, principal researcher on the study, which was co-written by graduate student Hee Shin Kim and emeritus professor of cell and developmental biology Jay E. Mittenthal. We are using the techniques of phylogenetic analysis that systematicists used to build the tree of life, and we are applying it to a biochemical problem, a systems biology problem.

To get at the roots of protein evolution, the researchers inspected metabolic proteins at the level of their component structures: easily identifiable folds in the proteins that have known enzymatic activities.

These protein domains catalyze a range of functions, breaking down or combining metabolites, small molecules that include the building blocks of all life.

Their findings relied on a primary supposition: that the most extensively utilized protein folds (they looked at proteins in more than 200 species) were also the most ancient.

Protein architecture has preserved ancient structural designs as fossils of ancient biochemistries, the authors wrote.

The team used data from two international collections of genetic and proteomic information: the metabolic pathways database of the Kyoto Encyclopedia
'"/>




Page: 1 2 3

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
5. Protein in urine foresees heart disease
6. Levels Of Blood Proteins May Help Heart Disease Care
7. Protein signals need for heart surgery
8. Protein and fat improve memory
9. Clotting Protein plays a role in nerve repair
10. High Levels of Protein Linked to Brain Shrinkage
11. Protein can change worn muscle fibres
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein Folds Research Offers Insight into Metabolic Evolution

(Date:7/31/2014)... 2014 Eden Lew has been ... - Crawford Technologies" Scholarship through EDSF ... to honor the contributions Chuck Forman made throughout ... Chuck lost his battle with cancer on October ... we are thrilled to see her receive the ...
(Date:7/31/2014)... 2014 Updox, the industry leader ... the release of a “Twelve Questions to Ask When Selecting ... are evaluating Health Information Service Providers (HISPs) for Direct Messaging ... MEDITECH and Epic electronic health records (EHRs) need to separately ... care using the Direct protocol. , “Selecting a ...
(Date:7/31/2014)... iFitDress.com, a professional company of women’s dresses and related ... new collection of high low wedding dresses . ... prices. In addition, worldwide clients can enjoy discounted shipping ... save both time and money for the international customers. ... all online visitors. On its website, people can order ...
(Date:7/31/2014)... Colorado (PRWEB) July 31, 2014 Daily Gossip ... will actually help sufferers discover some breakthrough weight loss tips. ... all these tips and recommendations are very simple to implement. ... eating healthy foods, with no need to start counting calories. ... Kyle Leon, who in fact created a 12 weeks weight ...
(Date:7/31/2014)... In its latest blog post, Best ... having family close by during a stay in rehab can ... is successful, is focusing on nine secrets that addicts don’t ... that they can spot an addict from a mile away, ... best Drug Rehabilitation’s CEO Per Wickstrom . “However, take ...
Breaking Medicine News(10 mins):Health News:Eden Lew Recipient of 2014 EDSF Scholarship Honoring Chuck Forman 2Health News:Eden Lew Recipient of 2014 EDSF Scholarship Honoring Chuck Forman 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 2Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 3Health News:Updox Introduces Resources to Help Hospitals Choose the Right HISP for Direct Messaging 4Health News:Discounted High Low Wedding Dresses Available At iFitDress.com 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 3
... Depression Management Program Employs Telephone Contact in TreatmentCOLUMBIA, S.C., ... (CBA) was awarded Silver Honors for Health ... organization, URAC . The honor was ... Health Care Consumer Empowerment and Protection Awards Gala ...
... to Draw Attention to Connecticut,s Growing Burden of Chronic Disease ... Loss Caused by CrisisHARTFORD, Conn., April 6 National and ... joining to launch a Partnership to call for comprehensive health ... disease here in Connecticut and across the nation. , ...
... study identify a biomarker that may be useful for predicting ... in young children. The research, published by Cell Press in ... , also provides new information about the molecular signals that ... cancer. , Retinoic acid (RA) is a metabolite of Vitamin ...
... nation to receive accreditationGREEN BAY, Wis., ... one of the first four hospitals in the ... Program for Breast Centers (NAPBC), administered by the ... program in Wisconsin to earn this recognition.(Logo: ...
... the level of patient care and streamline workflow for more efficient ... from the 2009 Annual HIMSS Conference & Exhibition at McCormick Place ... , ... Chicago, IL (PRWEB) April 6, 2009 -- ...
... A ,Biggest Loser, Finalist from the Lehigh ... Pa., April 6 Department of Health Secretary Everette James ... lunchtime fitness walk around the Capitol complex to bring awareness ... their own health. "As the state agency with ...
Cached Medicine News:Health News:Companion Benefit Alternatives Awarded Silver Honors for Best Practices in Health Plans and Health Networks by URAC 2Health News:Companion Benefit Alternatives Awarded Silver Honors for Best Practices in Health Plans and Health Networks by URAC 3Health News:Bipartisan CT Coalition Forms to Fight Spiraling Health Care Costs 2Health News:Biomarker associated with poor outcome in aggressive childhood cancer 2Health News:Aurora BayCare is Wisconsin's First Nationally Accredited Breast Program 2Health News:Orion Health Concerto Whiteboard Helps Emergency Rooms and Wards Track Patient Status 2Health News:Orion Health Concerto Whiteboard Helps Emergency Rooms and Wards Track Patient Status 3Health News:Secretary of Health 'Walks the Walk' to Kick Off National Public Health Week 2
(Date:7/31/2014)... De Pfizer Clinical Research Unit (PCRU) heeft ... van Japanse komaf voor medewerking aan klinisch onderzoek. De ... één van twee onderzoekseenheden van Pfizer , een ... door de ontdekking en ontwikkeling van nieuwe medicijnen. Om ... mannen en vrouwen van Japanse komaf – leeftijd 18 ...
(Date:7/30/2014)... 2014  Cepheid (Nasdaq: CPHD ) ... Premier will end on September 30, 2014.  Customers ... able to continue their relationship with Cepheid through ... and ROi, in addition to the recently announced ... "Cepheid has always recognized and supported the ...
(Date:7/30/2014)... 30, 2014 The Board of Directors ... last evening expressed support for the "Pharmacists, Patient ... of Pharmacy Practitioners (JCPP).  As a JCPP member, ... two-year period to develop a scalable, viable and ... "Pharmacists are fast becoming one of the ...
Breaking Medicine Technology:Gezonde vrijwilligers van Japanse komaf gezocht voor deelname aan Fase I klinisch onderzoek 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 3AMCP Endorses JCPP "Pharmacists' Patient Care Process" 2
... April 5, 2011 Danaher Corporation (NYSE: ... been promoted to Senior Vice President and Amir Aghdaei ... and Group Executive of Danaher. In his ... Danaher,s Dental segment, which includes KaVo Group and Sybron ...
... 5, 2011 Practice Fusion, the fastest growing ... $23 million Series B round of financing led ... Management and Glynn Capital Management, as well as ... round brings the company,s total funding to $30 ...
Cached Medicine Technology:Danaher Announces Executive Appointments 2Founders Fund Leads $23 Million Practice Fusion Financing Round 2Founders Fund Leads $23 Million Practice Fusion Financing Round 3Founders Fund Leads $23 Million Practice Fusion Financing Round 4Founders Fund Leads $23 Million Practice Fusion Financing Round 5
... patient tracking and billing. ... complete Handheld application, a ... complete CPT™ and ICD-9-CM ... AMA. Designed for any ...
... ToolBox is an advanced medical ... Emergency, Pediatric Dosing and Critical ... is a logical complement to ... as the Daviss Drug Guide, ...
... the handheld version of ... drug interaction analyzer covering ... generic drugs. iFacts™ enables ... to accurate and reliable ...
A handy, quick reference for physicians, nurses, and other health care providers treating cancer patients....
Medicine Products: