Navigation Links
Protective regimen for acute Graft-versus-host disease

Allogeneic hematopoietic-cell transplantation with the use of conditioning regimens of non-myeloablative radiotherapy, chemotherapy, or both to decrease early toxic effects extends the possibility of hematopoietic-cell// transplantation to patients older than 50 years and those with coexisting conditions.

However, acute graft-versus-host disease (GVHD) remains a major problem after non-myeloablative transplantation. Death due to this complication accounts for approximately 50% of the deaths that are not due to a relapse of the neoplasm.

Conditioning with total lymphoid irradiation plus anti-thymocyte serum has been previously shown to protect mice against acute GVHD after hematopoietic-cell transplantation.

Recently, a research team from the Stanford University School of Medicine, Stanford, California, tested this strategy in humans.

In a study published in the September issue of New England Journal of Medicine, 37 patients with lymphoid malignant diseases or acute leukemia underwent an experimental conditioning regimen with 10 doses of total lymphoid irradiation (80 cGy each) plus antithymocyte globulin, followed by an infusion of HLA-matched peripheral-blood mononuclear cells from related or unrelated donors who received granulocyte colony-stimulating factor.

Of the 37 transplant recipients, only 2 had acute GVHD after hematopoietic-cell transplantation. Potent antitumor effects in patients with lymphoid malignant diseases were shown by the change from partial to complete remission. In the transplant recipients who underwent conditioning with total lymphoid irradiation and antithymocyte globulin, the fraction of donor CD4+ T cells that produced interleukin-4 after in vitro stimulation increased by a factor of five, and the proliferative response to alloantigens in vitro was reduced, as compared with normal control subjects and control subjects who underwent conditioning with a single dose of total-body irradiation (200 cGy).

The study concludes that a regimen of nonmyeloablative conditioning of total lymphoid irradiation plus antithymocyte globulin given before hematopoietic-cell transplantation for lymphoid malignant diseases or acute leukemia can markedly decrease the incidence of acute GVHD while retaining the antitumor effect of the graft, and allows graft antitumor activity in patients with lymphoid malignant diseases or acute leukemia treated with hematopoietic-cell transplantation.
'"/>




Related medicine news :

1. Protective effects of tomatoes in prostate cancer
2. Olive Oil Found To Offer A Protective Effect Against Breast Cancer
3. Bird Flu: Orissa Initiates Protective Measures
4. Skin Cancer Cream Has A Protective Effect On Prematurely Aged Skin?
5. High Demand For Protective Suit in Afghan: Culling Would Have To Wait
6. Protective Protein Could Hold The Key In Fight Against Tuberculosis
7. Antibiotic Proved Protective against Heart Tissue Damage and Cell Death – Research Find
8. Protective Clothing of Health Workers Insufficent Against Contamination
9. Protective Intestinal Antibiotic Protein Discovered
10. Athletic Gear in Youth Not Protective Against Near Fatal Blows to chest
11. Know the Protective Face of the Sun
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... and Scientific Sessions in Dallas that it will receive two significant new grants ... grants came as PHA marked its 25th anniversary by recognizing patients, medical professionals ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
(Date:6/23/2016)... NORTHBROOK, Ill. and BOGOTA, Colombia , June 23, 2016  Astellas today announced the ... joins Astellas Farma Brasil as the company,s second affiliate in Latin America . ... ... appointed General Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: