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Protective Intestinal Antibiotic Protein Discovered

lationship with their gut microbes, but in patients with inflammatory bowel disease this tolerant relationship turns sour and the immune system mounts an attack on the gut's microbial inhabitants that can lead to painful ulcers and bloody diarrhea. What triggers this attack is not clear, but the fact that these patients have elevated HIP/PAP production suggests that they are coping with increased numbers of invading intestinal bacteria.

The study may also help scientists devise more effective treatments for intestinal infections. "We are now working to understand the mechanism by which the intestinal lining senses bacterial threats. What turns this protein antibiotic on?" Dr. Hooper asked. "We want to explore whether this is something we can stimulate artificially to stave off pathogenic infections."

Source : Eureka Aler
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