Navigation Links
Prostate cancer risk pronounced with selenium-protein deficiency

Selenium, which is known for its antioxidant properties in conjunction with proteins, is also becoming popular due to its contribution in bringing down incidence// of cancers, especially lung, colorectal and prostate.

"The problem is, nobody seems to know how the mechanism works, and that's not trivial," said Alan Diamond, professor of human nutrition at the University of Illinois at Chicago and principal investigator in an ongoing multidisciplinary study set up at UIC to help answer that question.

"Knowing how it works allows you to maximize-out its benefits," he said.

Diamond and his colleagues report in the May 23 issue of the Proceedings of the National Academy of Sciences on research findings using specially bred transgenic mice that suggest it is the level of selenium-containing proteins in the body that is instrumental in preventing cancer, and that dietary selenium plays a role in stimulating the body's level of these selenoproteins.

Two genetically manipulated mice were mated. One was prone to developing selenium-containing proteins in the body. The other had lower levels of selenoproteins. Approximately 50 offspring that carried both traits were studied to see if the reduced levels of selenoproteins accelerated cancer development. As the researchers suspected, it did.

"It's a hardcore link in an animal model system of selenium-containing proteins to prostate cancer and, by extrapolation, the mechanism by which selenium prevents cancer," said Diamond.

Further research is underway to corroborate the stimulating effect of dietary selenium in enhancing levels of protective selenoproteins. Diamond added that much work remains to be done to discover exactly how selenoproteins play their protective role, and in whom.

At least 25 different selenoproteins have been found in the human body. But what role each plays is not known, nor is it known if certain persons are genetically more -- or less -- receptive to the benefits of these proteins, or to a selenium supplement, Diamond said.

The effectiveness of selenium may be due to its effects on a single selenoprotein, or combinations of several members of this class. One selenoprotein in particular, glutathione peroxidase, is of special interest to Diamond and his associates. They plan to run new tests using new mice genetically modified to reduce levels of just this one selenoprotein.

"If reductions result in accelerated prostate cancer, then we have our player," he said.

Other UIC faculty participating in the study include Veda Diwadkar-Navsariwala, post-doctoral researcher in human nutrition; Gain Prins, professor of urology; Steven Swanson, associate professor of medicinal chemistry and pharmacognosy; Lynn Birch, research specialist in urology; Vera Ray, clinical assistant professor of pathology; Sadam Hedayat, distinguished professor of statistics; and Daniel Lantvit, research specialist in pharmaceutical sciences.

source :Eureka Alert
'"/>




Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
3. New Prostate Cancer Vaccine Shows Promise
4. Hormone Therapy applicable for Prostate Cancer
5. Prostate cancer and Vitamins
6. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
7. Early Detection Of Prostate Cancer
8. Awareness increase Prostate cancer detection
9. Better Prostate Cancer Test
10. Stopping Prostate Cancer from Spreading
11. Drug might prevent Prostate Cancer Spread
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2017)... ... ... Goodcents Deli Fresh Subs announced a franchise expansion agreement today including three ... The first new location will open at the corner of 27th and Randolph in ... Drive this fall. And the third location is in the process of being identified. ...
(Date:4/27/2017)... ... April 27, 2017 , ... Are you investing in the ... water-related accidents and drownings during the summer. While most of us assume this type ... occur every day. Very few people are taking the time to learn how to ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... management in hospitals, today announced it has completed a round of funding to ... LLC and its partners. Black Granite Capital is a growth equity firm focused ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... Journal ... adults. It can have severe consequences to overall dental health, including complications with speech, ... often turn to dental implants to replace lost teeth. As the number of tooth ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... the adoption of e-prescribing as measured in Part D Medicare data. The dataset, ... to pharmacies, either using e-prescribing, faxes or paper. The PaPR (pronounced "paper") ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  AbbVie (NYSE: ABBV), a global ... of chronic hepatitis C virus (HCV) infected patients ... and compensated cirrhosis (Child-Pugh A) achieved sustained virologic ... with its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). ... following 12 weeks of G/P treatment without ribavirin. ...
(Date:4/20/2017)... 20, 2017 Eyevensys, a private ... non-viral gene expression technology that enables the safe, local, ... address a wide range of ophthalmic diseases, announces it ... products Regulatory Agency (MHRA) to advance its technology into ... ...
(Date:4/20/2017)... -- Research and Markets has announced the addition ... Analysis By Service (Manufacturing, Research), By Country, (Brazil, Mexico, Colombia, ... report to their offering. ... The Latin American pharmaceutical contract manufacturing services market is ... Low drug registration cost in Latin American countries and continuous ...
Breaking Medicine Technology: