Navigation Links
Prostate Cancer Therapy may Increase Risk of Death in Older Patients

Androgen deprivation therapy - one of the most common treatments for prostate cancer - may increase the risk of death from heart disease// in patients over age 65, according to a new study.

The study results were based on data from CaPSURE, a national registry of men with prostate cancer. Although the findings need to be confirmed in clinical trials, the study authors state that oncologists should weigh the benefits of androgen deprivation therapy, or ADT, against the risk of heart problems in older prostate cancer patients.

The goal of ADT is to block the level of circulating androgens (male hormones), which can fuel the growth of prostate cancers. "Androgen deprivation therapy is associated with elevated body mass index, increased body fat deposits and diabetes, all of which raise the risk of death from heart diseased," explains the study's lead author, Henry Tsai, MD, a resident physician at Dana-Farber, Brigham and Women's and the Harvard Radiation Oncology Program.

"Although our findings demonstrated that older men receiving this treatment may be at increased risk, even after taking into account other cardiovascular risk factors, a prospective clinical trial would be needed to confirm a cause-and-effect relationship."

Drawing on the CaPSURE database, Tsai and his colleagues compared the number of cardiac-related deaths among 735 men with localized prostate cancer who received ADT and among 2,901 men with the disease whose treatment did not include ADT.

After factoring in other known risks for cardiovascular disease (such as diabetes, hypertension, body mass index and smoking), researchers found that the longer patients received ADT, the sooner they were likely to die from heart disease. When the researchers analyzed the data by patients' age, the link between ADT use and death from heart disease was significant in patients over age 65, but not in those under 65. After five years, 3 percent of older me n who received androgen deprivation therapy died of cardiac causes, compared with only 0.9 percent of men who did not receive the therapy.

"These findings should help oncologists determine which older patients are the best candidates for ADT," Tsai remarks. "If a patient is at high risk of cardiovascular disease, it would be advisable for an oncologist to discuss the pros and cons of ADT treatment with him before proceeding on a course of treatment."

Source-Eurekalert
'"/>




Related medicine news :

1. Cancer Doctors Okays Controversial Prostate Therapy
2. Radioactive Seeds used in Prostate Cancer treatment can migrate with the body
3. New Prostate Cancer Vaccine Shows Promise
4. Hormone Therapy applicable for Prostate Cancer
5. Prostate cancer and Vitamins
6. Response to chemotherapy could be measured by Prostate-Specific Antigen Doubling Time
7. Early Detection Of Prostate Cancer
8. Awareness increase Prostate cancer detection
9. Better Prostate Cancer Test
10. Stopping Prostate Cancer from Spreading
11. Drug might prevent Prostate Cancer Spread
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2016)... ... , ... With the FCPX LUT: Summer pack from Pixel Film ... LUT is a Lookup Table that contains a mathematical formula for modifying an image. ... By manipulating each pixel, LUT's can change each color range differently, it gives the ...
(Date:2/5/2016)... ... , ... Steven Tonkinson, 36, of Coconut Grove, Florida, ran the Miami Marathon ... 2003. This year, he ran all 26.2 miles with a green 25-pound ShelterBox strapped ... Heat. , This Sunday, while many are watching the Superbowl, Steven Tonkinson will strap ...
(Date:2/5/2016)... & Salt Lake City, UT (PRWEB) , ... February 05, 2016 ... ... of Activz Whole-Food Nutrition , announced that the much-anticipated feature with author Jahnavi ... New Really Cool Humans Amateur TV Network. , Each week, on his weekly Whole-Food ...
(Date:2/5/2016)... Miami, FL (PRWEB) , ... February 05, 2016 ... ... of the largest domestic franchisees of Popeyes Louisiana Kitchen restaurants, launched the 14th ... and awareness for kids and adults with muscular dystrophy, ALS and related diseases ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President ... have signed a joint enrollment and degree completion agreement. The agreement, which ... baccalaureate degrees at FHU|Dickson. , The agreement allows students to be jointly ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... , Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: ... care products and services to office-based dental, animal health ... into an agreement to acquire a majority ownership interest ... and equipment in Brazil . ... in Blumenau, Brazil, Dental Cremer is the dental distribution business ...
(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ... "Global Obstetrics Partnering 2010-2016: Deal trends, ... their offering. --> http://www.researchandmarkets.com/research/hcdvg6/global_obstetrics ) ... "Global Obstetrics Partnering 2010-2016: Deal trends, players ... offering. --> Research and Markets ...
(Date:2/4/2016)... -- The Senior Care Pharmacy Coalition (SCPC) today commended ... Jason Chaffetz (R-UT) and Ranking Member Elijah ... "Developments in the Prescription Drug Market," to examine ... abusive pharmacy benefit manager (PBM) pricing practices. ... Elijah Cummings (D-MD) are diligent, serious lawmakers committed ...
Breaking Medicine Technology: