Navigation Links
Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism

By first probing the way primitive yeast make cholesterol, a team of scientists has discovered a long-sought protein whose human// counterpart controls cholesterol production and potentially drug metabolism.

The collaborative study by investigators at Johns Hopkins University School of Medicine, Vanderbilt University, Indiana University and Eli Lilly Co., was published in the February issue of Cell Metabolism.

“Dap1 controls the activity of a clinically important class of enzymes required for cholesterol synthesis and drug metabolism,” says Peter Espenshade, Ph.D., assistant professor of cell biology at Johns Hopkins. “We’re excited because although we originally identified this protein in yeast, humans not only have the same protein, but it works the same way.”

The search for Dap1 began with the hunt for factors that influence the actions of a large family of enzymes called cytochrome P450. These enzymes control many life-sustaining chemical reactions in humans and other animals.

Happily, Espenshade says, yeast have only two P450 enzymes, and both play roles in making cholesterol, narrowing down the territory for their search and giving them a telltale marker (the cholesterol) to track.

Reasoning that whatever controls the P450s likely would be turned on and off at roughly the same time as the P450 enzymes themselves, the researchers found that Dap1 does just that in the yeast cell.

To figure out what Dap1 does, Espenshade and colleagues genetically altered yeast cells to lack Dap1. Those cells predictably were unable to make cholesterol and instead contained a build-up of cholesterol precursors.

The research team then tracked Dap1’s counterpart in humans by looking for similar proteins in a computer database and repeated their experiments in human kidney cells engineered to lack the human version of Dap1. As in yeast, the altered human cells accumulated cholesterol precursors and
'"/>




Page: 1 2

Related medicine news :

1. Yeast Genome Unravels Genes Critical For Maintaining DNA Integrity
2. Yeast Model Shows Promise as Alzheimers Test
3. Chinese Red Yeast Rice Lowers Lipid Levels
4. From a Lowly Yeast, Researchers Divine a Clue to Human Disease
5. Vitamin Extends Life in Yeast, Dartmouth Medical School Researchers Find
6. Operating on a Beating Heart Yields Better Results For Blocked Heart Arteries
7. Fight the Flab Competition Yields Great Results
8. Exercise Combined with Dialysis Yields Better Results
9. Kyphoplasty Yields Good Long-Term Improvement for Spinal Fractures
10. MRI Development Yields Breakthrough in Diagnosis of Liver Fibrosis
11. Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
Post Your Comments:
(Date:10/25/2014)... 24, 2014 (HealthDay News) -- October,s shorter, darker days ... affective disorder, according to an expert. People ... feel overly tired, lack motivation and even have trouble ... lead to suicide, said Dr. Angelos Halaris, a professor ... Loyola University Chicago Stitch School of Medicine. "Seasonal ...
(Date:10/22/2014)... Medical Solutions , the ... to announce that our co-founder and CFO, Scott ... Staffing 100 for 2014. Anderson was also named ... people in the staffing industry,” in 2013.     , ... healthcare staffing company in the U.S., was named ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- The ... passengers arriving from Ebola-affected nations of West Africa ... screen them for infection with the virus. ... Jeh Johnson noted that 94 percent of air ... land at one of these five airports -- ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a world ... face, it certainly can be difficult to choose the right ... favor by doing it the healthy way? Set aside the ... your body, exercise regularly, and choose foods with the most ... you need to exercise more and eat less. Despite the ...
Breaking Medicine News(10 mins):Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2
... new diagnostic technique capable of producing three-dimensional, in-depth ... number of women who are recalled for additional ... clinical trial being conducted at Emory University Breast ... annual meeting of the Radiological Society of North ...
... Procedures through the Belly Button: Scar-Free ... ... Nov. 28 Cleveland Clinic urologists recently,performed a series of ... repair), ileal ureter replacement, and psoas hitch uretero-,neocystostomy (for ureteral ...
... Medical Entrepreneurs is Only a Phone Call or ... care entrepreneurs,working outside the traditional health insurance payment ... computer software to make,medical care more accessible and ... the National Center for Policy Analysis (NCPA)., http://www.ncpa.org/pub/st/st305/st305.pdf ...
... Be Presented at 9:00 a.m. ... ... The Trade, Health and Environment,Impact Project, a collaboration of community organizations ... East Yard Communities for Environmental Justice, Center for,Community Action & Environmental ...
... and clinical ... development experience to Celator., PRINCETON, N.J., ... develop combination chemotherapies to,treat different types of cancer, today ... R. Appelbaum, M.D., head of the,University of Washington School ...
... that had the neurological disease, researchers say , WEDNESDAY, ... to a possible treatment for amyotrophic lateral sclerosis (ALS), ... a protein normally found in human cells into mice ... The team found that the treatment delayed symptoms and ...
Cached Medicine News:Health News:'Stereo' mammography takes breast imaging to a new dimension 2Health News:World Firsts by Cleveland Clinic Urologists 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 3Health News:Los Angeles Port Pollution, Int'l Trade & Goods Movement Conference This Weekend 2Health News:Frederick R. Appelbaum, M.D. and Ross C. Donehower, M.D. Join Scientific Advisory Board of Celator(R) Pharmaceuticals 2Health News:Cell Protein Might Help Treat ALS 2
(Date:10/25/2014)... , Oct. 24, 2014   Metanome, Inc. ... comprehensive metagenomic services and data analysis, was the genomic ... ) Phase I/II clinical trial of SER 109, ... recurrent Clostridium difficile infections (CDI). ... Seres Health,s R&D and clinical programs. Such genomic characterization ...
(Date:10/25/2014)... , October 24, 2014 ... http://www.researchandmarkets.com/research/wdq92g/global_and ) has announced the addition of ... Report 2014"  report to their offering.  ... Global and Chinese Acne Medication Industry Report ... on the current state of the global ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
Breaking Medicine Technology:Metanome Selected as Metagenomics Provider for Seres Health Clinical Trial 2Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3Strong Participation in Best Practices' Medical Affairs Consortium Survey 2
... Nov. 3, 2010 Telik, Inc. (Nasdaq: TELK ... $0.09 per share, for the third quarter ended September 30, ... $0.11 per share, for the comparable period in 2009. ... costs and expenses were $4.7 million, compared with $6.2 million in ...
... N.J., Nov. 3, 2010 Regado Biosciences, a privately ... active control agents, announced that Ellen McDonald, MBA, Senior ... at IMPACT 2010 held at the Pennsylvania Convention Center ... at 11:13 a.m. EST on Wednesday, November 10 in ...
Cached Medicine Technology:Telik Announces Third Quarter 2010 Financial Results 2Telik Announces Third Quarter 2010 Financial Results 3Regado Biosciences to Present at the IMPACT 2010 Conference in Philadelphia, Pennsylvania 2Regado Biosciences to Present at the IMPACT 2010 Conference in Philadelphia, Pennsylvania 3
96-Well PCR Plate Sealing Mat...
Easy to pierce, remove using foil stripper...
Inquire...
... Sealing Foil and Heat Sealing Film each provide ... safe and easy sample storage. In automated procedures ... standard pipette tips. The Heat Sealing Film is ... the plates. Heat Sealing Foil is removed by ...
Medicine Products: