( The take-home message is that we sa...)Preterm Labor Drug Causes More Side Effects,Health

"The take-home message is that we saw no differences in relevant outcomes between the two groups," said Lyell, "but there was a significant difference in the side effects experienced by the women, and some of these were very serious."

Lyell and El-Sayed emphasized that magnesium sulfate is still an appropriate treatment for preterm labor. It continues to be used regularly both at Packard Children's and Santa Clara Valley Medical Center. But they believe it may be time for physicians to give more weight to expected side effects when considering what to try first.

"It's been my experience that women who have had magnesium sulfate remember it; they don't like it," said Lyell. "Those who receive nifedipine don't feel as bad. These drugs are prescribed under what are already very difficult circumstances for the patients, and side effects are very important to them.


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