( ategory was created by UNOS in 2002 so ...)Preserving Kidneys on a Pump May Promote More Organ Sharing,Health

ategory was created by UNOS in 2002 so that higher risk donor organs, once considered unsuitable, could be transplanted safely. The category includes kidneys from deceased donors over age 60 years or those over age 50 with health conditions such as high blood pressure, stroke or elevated levels of a protein called creatinine. Levels of creatinine, which is produced by muscle, are used to determine kidney function.

The current study included 120 ECD kidney transplants -- 95 kidneys were preserved with machine and 25 with simple cold storage preservation techniques.

Despite the fact that the machine-preserved kidneys were out of the body for a longer period of time (a mean of 24 hours versus 19 hours for the cold stored organs), both groups of recipients had similar survival and functional outcomes. In addition, the patients receiving machine-preserved kidneys had a 50 percent reduction in the rates of viral infections and delayed graft function, which is the inability of the kidneys to start working on their own without dialysis.

The routine use of machine preservation for ECD kidneys may lower hospital costs by reducing complications, said Stratta. In addition, it may promote more sharing of organs; it is a superior means of preserving organs out of body and provides a way to assess the viability of the organ.

Stratta said machine preservation has played an important role in the Medical Centers success transplanting kidneys at the outer limits of the ECD acceptance criteria, such as organs donated after cardiac death, preserved for more than 30 hours, or from donors over age 70. In previous studies with up to four years of follow-up data, Stratta has shown that success rates with these organs are equivalent to those of conventional donors, in part because of appropriate donor and recipient matching through using the pump to assess viability and function.


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