Navigation Links
Prematurity More Accurately Predicted by Advances in Proteomic Technology

Abnormal proteins in amniotic fluid that signal a higher risk of delivering prematurely are being detected with increasing accuracy// by Yale School of Medicine researchers who presented their work in two abstracts at the Society for Maternal-Fetal Medicine Conference February 8 in San Francisco.

In both studies, the researchers demonstrated that women with abnormal proteomic profiles (MR scores) are more likely to have inflammation and infection. The researchers previously developed the novel MR scoring method to discriminate healthy from diseased women in whom preterm delivery is impending and the health of the fetus is in danger. MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm.

A normal MR score is 0 and a score of 3-4 is indicative of infection. The proteins detected are human neutrophil defensin 1, human neutrophil defensin 2, calgranulin C and calgranulin A.

About 50 percent of women who deliver prematurely have evidence of inflammation in the amniotic fluid. While there are many proteins in the amniotic fluid, not all are biomarkers with diagnostic significance.

The research team analyzed and generated MR scores for amniotic fluid taken from 123 women admitted to the Labor and Birth Unit or the prenatal units at Yale-New Haven Hospital. They found a direct relationship between the degree of amniotic fluid inflammation as indicated by the MR score, and the severity of infection in the placenta and umbilical cord.

“Our data suggest that at the time of amniocentesis and prior to delivery of the fetus, clinicians can be reassured by the absence of inflammation in a patient with an MR score of ‘0.’ Or they can initiate aggressive therapy immediately following delivery when there is an MR score of 3 or 4,” said first author on the abstracts Irina Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gy necology & Reproductive Sciences at Yale School of Medicine.

Buhimschi said that neonates born to women with an MR score of 3-4 had an increased incidence of infection. They also found that calgranulin C most accurately predicted inflammatory cell infiltration of the umbilical cord, and calgranulin A reflected more advanced inflammation, which is predictive of early-onset neonatal infection.

“Early recognition, diagnosis and treatment of neonatal infection are important aspects of the current clinical practice,” said Buhimschi. “Therefore, prospective randomized studies to determine the appropriate treatment of newborns based on the MR score are highly desirable.”

Source-YALE UniversityBR>SRM
'"/>




Related medicine news :

1. CT Scans Said to Accurately Detect Small Cancers
2. Can Men Gauge Biological Paternity Accurately
3. Bipolar Disorder Not Being Accurately Diagnosed By Doctors In UK
4. High Resolution CT Accurately Diagnoses Shin Splints
5. Automated Technique Accurately Measures Platelet Counts in "Platelet Gel" Products
6. MDCT Accurately Locates Bowel Perforation: Study
7. MR Angiography Detects Blocked Arteries Accurately
8. Body Mass Index may Not Reflect Fat Accurately
9. Simple System Accurately Predicts Weight-loss Surgery Risk
10. Long-Term Survival can be Predicted by a Simple Lung Test
11. Risk of Heart Attack Can Now Be Predicted
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/21/2017)... Los Angeles, CA (PRWEB) , ... April 21, 2017 , ... ... in Northern Italy of a pair of ancient teeth, which reveal a great deal ... have deduced that a sharp stone may have been used to remove decayed dental ...
(Date:4/21/2017)... ... April 21, 2017 , ... Evoke Therapy Programs ... has kicked off its 4th annual Forum for Innovative Treatment Solutions (FITS), which ... Informed Therapy for Mental Health and Addiction.” , FITS’ 2017 keynote presenters ...
(Date:4/21/2017)... ... 2017 , ... The Patient Advocacy Community of The Beryl Institute presented Eve ... Ravich Patient Advocacy Award in recognition of her extraordinary contributions to the field ... at The Beryl Institute’s annual Patient Experience Conference on March 20 in ...
(Date:4/21/2017)... ... April 21, 2017 , ... Alive for Wellness is a ... their mental health struggles. The Alive team uses advanced behavioral sciences treatment modalities ... dealing with a mental health struggle is based on 10 modalities of treatment ...
(Date:4/21/2017)... CA (PRWEB) , ... April 21, 2017 , ... Providing ... not understand the estate planning process, or where to even begin. “Now more than ... if you are to properly protect yourself and your family,” said attorney Lisa Edgar ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 20, 2017  RXi Pharmaceuticals Corporation (NASDAQ: RXII), ... address significant unmet medical needs, today announced that ... consumer product development program, based on its proprietary ... Investigative Dermatology (SID) 76 th Annual Meeting.  ... the sciences relevant to skin health and disease ...
(Date:4/20/2017)... 20, 2017 Research and Markets has ... Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, ... their offering. ... pharmacogenomics market was valued at US$ 7,167.6 Mn in 2015, ... expanding at a CAGR of 5.6% from 2016 to 2024. ...
(Date:4/19/2017)... YORK , April 19, 2017 Cardiology devices ... the projected period The Cardiology Devices segment is ... than US$ 15 Mn in 2018 over 2017. By the ... a market valuation close to US$ 700 Mn, expanding at ... Devices segment dominated the Asia Pacific ...
Breaking Medicine Technology: