Navigation Links
Prematurity More Accurately Predicted by Advances in Proteomic Technology

Abnormal proteins in amniotic fluid that signal a higher risk of delivering prematurely are being detected with increasing accuracy// by Yale School of Medicine researchers who presented their work in two abstracts at the Society for Maternal-Fetal Medicine Conference February 8 in San Francisco.

In both studies, the researchers demonstrated that women with abnormal proteomic profiles (MR scores) are more likely to have inflammation and infection. The researchers previously developed the novel MR scoring method to discriminate healthy from diseased women in whom preterm delivery is impending and the health of the fetus is in danger. MR scoring relies on identification of a group of proteins that serve as biomarkers characteristic to women who will deliver preterm.

A normal MR score is 0 and a score of 3-4 is indicative of infection. The proteins detected are human neutrophil defensin 1, human neutrophil defensin 2, calgranulin C and calgranulin A.

About 50 percent of women who deliver prematurely have evidence of inflammation in the amniotic fluid. While there are many proteins in the amniotic fluid, not all are biomarkers with diagnostic significance.

The research team analyzed and generated MR scores for amniotic fluid taken from 123 women admitted to the Labor and Birth Unit or the prenatal units at Yale-New Haven Hospital. They found a direct relationship between the degree of amniotic fluid inflammation as indicated by the MR score, and the severity of infection in the placenta and umbilical cord.

“Our data suggest that at the time of amniocentesis and prior to delivery of the fetus, clinicians can be reassured by the absence of inflammation in a patient with an MR score of ‘0.’ Or they can initiate aggressive therapy immediately following delivery when there is an MR score of 3 or 4,” said first author on the abstracts Irina Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gy necology & Reproductive Sciences at Yale School of Medicine.

Buhimschi said that neonates born to women with an MR score of 3-4 had an increased incidence of infection. They also found that calgranulin C most accurately predicted inflammatory cell infiltration of the umbilical cord, and calgranulin A reflected more advanced inflammation, which is predictive of early-onset neonatal infection.

“Early recognition, diagnosis and treatment of neonatal infection are important aspects of the current clinical practice,” said Buhimschi. “Therefore, prospective randomized studies to determine the appropriate treatment of newborns based on the MR score are highly desirable.”

Source-YALE UniversityBR>SRM
'"/>




Related medicine news :

1. CT Scans Said to Accurately Detect Small Cancers
2. Can Men Gauge Biological Paternity Accurately
3. Bipolar Disorder Not Being Accurately Diagnosed By Doctors In UK
4. High Resolution CT Accurately Diagnoses Shin Splints
5. Automated Technique Accurately Measures Platelet Counts in "Platelet Gel" Products
6. MDCT Accurately Locates Bowel Perforation: Study
7. MR Angiography Detects Blocked Arteries Accurately
8. Body Mass Index may Not Reflect Fat Accurately
9. Simple System Accurately Predicts Weight-loss Surgery Risk
10. Long-Term Survival can be Predicted by a Simple Lung Test
11. Risk of Heart Attack Can Now Be Predicted
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor Janice ... of cardiovascular diseases during the 15th Annual Women’s Health Conference. The SIU ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/25/2017)...   Montrium , an industry leader in ... IQPC Trial Master Files & Inspection Readiness Conference ... Clinical Services has selected eTMF Connect ... EastHORN, a leading European contract research organization (CRO), ... to enable greater collaboration with sponsors, improve compliance ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology: