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Preimplanted Genetic Screening Should Be Interpreted With Caution

ins hospital has decided to offer PGS only to patients after they have undergone more than 6 previous failed IVF cycles, been checked for and found to have normal chromosomal make-up, and produced more than 6 good quality embryos.

Even in cases that fulfil these conditions, we nevertheless prefer transferring more embryos back to the uterus rather than carrying out PGS biopsies for them on day 3, assuming that natural selection will usually favour the normal embryos for implantation, she says.

Our results can explain why PGS would not be able to increase pregnancy potential but rather can serve as a prognostic tool in a limited number of cases, says Ms Frumkin. It can also help us make optimal decisions about the value of switching to a different assisted reproduction technique, for example egg donation.




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