Navigation Links
Preimplanted Genetic Screening Should Be Interpreted With Caution

According to scientist at annual conference of the European Society of Human Genetics embryos that are selected out as abnormal can undergo chromosomal modifications.

Ms Tsvia Frumkin, from the Racine IVF unit, LIS Maternity Hospital, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel, will tell the conference that her teams findings meant that the results of preimplantation genetic screening (PGS) for chromosomal abnormalities were not always reliable and should be interpreted with caution.

PGS is offered to women with recurrent IVF failures as well as repeated miscarriages. It is based on the concept that the entire chromosomal constitution of an embryo can be represented by a single cell, which is removed from the embryo. If one biopsied cell is found to be abnormal, there is a 90% chance that the rest of the embryo is also abnormal or mosaic, where two or more cells with different chromosomal constitution exist in a single embryo.

Ms Frumkin analysed 8 cell embryos at day 3 of development using the FISH (fluorescence in situ hybridization) technique. Two cells from each embryo were analysed, and between 5 and 9 chromosomes were investigated. The abnormal embryos were re-analysed on day 5, using the same method.

By comparing FISH results of day 5 embryos to the abnormal results of the same embryos on day 3, we could elucidate the origin of the chromosomal aberrations and follow different chromosomal modifications as they occurred during preimplantation period. The timing is significant because embryos used in IVF are normally transferred at between 3 and 5 days old, says Ms Frumkin.

We found that embryos which were abnormal on day 3 demonstrated a high rate of mosaicism However, on day 5 some of them had undergone self-correction into normal embryos. Others kept the same abnormalities, while some had acquired additional chromosomal abnormalities, she says.

Following the research, Ms Frumk ins hospital has decided to offer PGS only to patients after they have undergone more than 6 previous failed IVF cycles, been checked for and found to have normal chromosomal make-up, and produced more than 6 good quality embryos.

Even in cases that fulfil these conditions, we nevertheless prefer transferring more embryos back to the uterus rather than carrying out PGS biopsies for them on day 3, assuming that natural selection will usually favour the normal embryos for implantation, she says.

Our results can explain why PGS would not be able to increase pregnancy potential but rather can serve as a prognostic tool in a limited number of cases, says Ms Frumkin. It can also help us make optimal decisions about the value of switching to a different assisted reproduction technique, for example egg donation.




'"/>




Related medicine news :

1. Genetic Dentistry: Your Dentist may be able to grow you a new set of Teeth.
2. Genetic influence in menopause
3. Genetics and cholesterol levels
4. Genetics helps in attacking cancer
5. Genetic disorder related with sleep patterns
6. Genetic innovation
7. Genetic tests for cancer
8. Genetic indicates memory
9. Genetic mutation to the fountain of youth discovered
10. Genetic differences found between Male and Female brains
11. Alcoholism Influenced By Both Genetics & Family Environment
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2016)... ... February 13, 2016 , ... In the early or “honeymoon” stage of a ... go out of their way to be romantic, and may exaggerate a strength or ... any online dating profile. , A recent study from Queendom.com , however, ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the advanced skills needed ... top students from U.S. universities who will draw from Siemens’ deep knowledge ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... As a ... hectic schedule, a demanding job, and no time to decompress, Rabinowitz found herself drawn ... herself to meditation for its impact on her life, implementing a 20-minute-per-day meditation practice ...
(Date:2/12/2016)... ... February 12, 2016 , ... Every winter, someone is killed, injured ... West Penn Burn Center, part of the Allegheny Health Network, has partnered ... you the “Space Heaters Need Space” campaign. , “Space Heaters Need Space” ...
(Date:2/12/2016)... ... 12, 2016 , ... Erlanger Agency has announced a new partnership in its ... campaign focuses on the fight against breast cancer, fundraising for a local woman named ... . , Carmen is a loving single mother of two boys who also serves ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... MONTREAL , February 12, 2016 ... sofern nicht anders vermerkt)   ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... Website des Unternehmens http://www.telestatherapeutics.com ... Inc. (TSX:TST; PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss ...
(Date:2/12/2016)... 12, 2016  SI-BONE, Inc., a medical device company that pioneered ... minimally invasive surgical (MIS) device indicated for fusion for certain disorders ... (NGS), the Medicare Administrative Contractor (MAC) covering the states of ... Maine , Massachusetts , Minnesota ... York , Rhode Island , ...
(Date:2/12/2016)... , Feb. 12, 2016  Memorial Hermann Health System ... Dwight Howard to bring a one-of-a-kind experience to ... Using cutting-edge technologies such as 360-degree video and Google ... virtually, then literally – giving the patients and their ... it was all caught on video . ...
Breaking Medicine Technology: