Navigation Links
Pregnant Women With Lupus Are At Greater Risk

Researchers from Duke Medical Center have found that pregnant women with systemic lupus are at higher risk for death and other medical complications compared to normal// pregnant women.

The study, believed to be largest of its kind, was conducted nationwide covering more than 18 million women. The study suggested that pregnant women with systemic lupus should be considered a high-risk population and should be monitored closely by both a rheumatologist and an obstetrician who specializes in caring for high-risk patients.

"Pregnant women with lupus should never try to go through their pregnancy alone and simply hope for the best," said study leader Megan Clowse, M.D., M.P.H., assistant professor in the Division of Rheumatology. "They should stay in close contact with their doctors and report any problems immediately."

Clowse presented the findings on Sunday, Nov. 12, at the annual meeting of the American College of Rheumatology, in Washington, D.C. The National Institutes of Health’s Building Interdisciplinary Research Careers in Women’s Health program funded the study.

Lupus is an autoimmune disease in which the immune system loses its ability to distinguish between "self" and foreign substances and thus relentlessly attacks the body's own tissues and cells. Individuals with lupus often exhibit many different symptoms, including arthritis, kidney disease, rashes, fevers, anemia and sensitivity to light, among other problems.

Approximately 1.5 million Americans -- roughly 90 percent of them women -- have some type of lupus. Most patients are diagnosed during their reproductive years. Seventy percent of patients have systemic lupus, the most severe form of the disease.

All women with systemic lupus, pregnant or not, are at increased risk for death and medical complications compared to a healthy population, Clowse said. Other studies report that each year, between 0.8 percent and 3 percent of lupus patients die from the disease.

Previous research also has shown that pregnancy can increase the activity level of lupus, increasing the danger to the woman and sometimes causing problems in her fetus, according to Clowse. What was not certain, she said, is how much lupus increased a woman's health risk.

To help answer this question, Clowse's team analyzed data from more than 18 million pregnancy-related hospital admissions and discharges in the United States from 2000 to 2002. The study found that slightly more than 13,500 women with systemic lupus gave birth during this time, and 44 of the women -- 0.3 percent -- died, Clowse said.

Overall, women with systemic lupus showed a more than 20-fold greater risk of pregnancy-related death, compared with women without the disease, she said. Extrapolating this observed increase in risk to the general population suggests that for every 100,000 women with systemic lupus who would deliver a baby, approximately 325 of them would die, compared with approximately 14 deaths for every 100,000 women without the disease who would give birth, Clowse said.

"We don't want these results to scare women with lupus away from getting pregnant, especially if they have a mild form of the disease," Clowse said. "But these women really must plan their pregnancies. They may need to change their medications before they get pregnant, and they really shouldn't conceive when their lupus is active."

Clowse said patients whose lupus has been dormant for at least six months before conception are at low risk for developing active systemic lupus during pregnancy and therefore are at least somewhat less likely than women whose disease is active to experience health complications.

However, all women with systemic lupus do face elevated risks for pregnancy complications, she said. In the study population, women with systemic lupus, compared to women without the disease, were nearly six times more likely to suff er from deep vein thrombosis -- a blood clot -- and 3.5 times more likely to develop sepsis, a severe illness caused by an extreme infection of the bloodstream. Many women with lupus also were anemic or had low blood platelet counts at delivery and were three times more likely to need transfusions.

Additionally, almost 37 percent of women with lupus gave birth via cesarean section -- 15 percent higher than the national average of 22 percent. Women with lupus also were 2.5 times more likely to experience preterm labor and three times more likely to develop preeclampsia, or pregnancy-related high blood pressure, than women without lupus.

Clowse said the study's results are highly suggestive and should be taken seriously within the health care community, but she added that the study did have certain limitations.

On the plus side, the study examined a large number of patients, including patients from a variety of clinical environments, and it compared pregnancy results among women with and without lupus, she said.

However, she added, the study relied on analyzing hospital admission and discharge data, rather than on analyzing individual patient records or on examining the patients themselves.

Source-Eurekalert
SR
'"/>




Related medicine news :

1. Pregnant smokers could harm their child
2. Risk for Pregnant Women
3. Pregnant women more prone to depression
4. The Effects Of Fish On Pregnant Women Questioned
5. Relieving Pelvic Pain In Pregnant Women
6. Pregnant mothers dental health can lead to pre-term babies
7. Listeria Food Poisoning Can Be Dangerous In Pregnant Women And Elderly
8. The Dangers Of Vitamin A To Pregnant Women To Be Included On Label
9. Trained Counselors Counseling Pregnant Smokers To Quit May Not Work
10. Good Response from Pregnant Women in Delhi for Free ART Therapy
11. London Hospital Provides Specialized Care For Pregnant Women
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy Specialists (TexPTS) is ... in Building 2. The clinic is the group’s second in New Braunfels and 22nd ... company’s second New Braunfels location brings things full circle for the group, “It’s crazy ...
(Date:3/23/2017)... ... ... The IoT (Internet of Things) is revolutionizing the way the world operates. ... individual consumers alike. Laboratories can maximize their profit margin by increasing throughput. ... to $11 trillion dollars by the year 2025. McKinsey expects the IoT to have ...
(Date:3/23/2017)... ... 23, 2017 , ... 82% of adults are unaware of the dangers that infectious bacteria play ... the minimum two times a day that dentists recommend. The ramifications of improper oral upkeep ... school and adults missing 164 million hours of work each year due to dental issues. ...
(Date:3/23/2017)... ... , ... March is National Kidney Month – the perfect time to pause ... good health. Every day, two kidneys filter about 120 to 150 quarts of blood. ... eliminating waste, regulating fluid levels and blood pressure, supporting bone health and promoting red ...
(Date:3/23/2017)... ... 2017 , ... The StayWell Company announced today that it ... StayWell’s asthma, coronary artery disease, congestive heart failure, chronic obstructive pulmonary disease, and ... programs for the delivery and improvement of disease management and that meet or ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... FinancialBuzz.com News Commentary  ... According to new data published Arcview ... legal cannabis market is projected to continue to grow at ... the current presidential administration. The report created by Arcview,s data ... growth in this industry are the passage and subsequent implementation ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced the ... report to their offering. ... The IPF pipeline is very strong with a total of 97 ... Inc., Biogen and Sanofi are involved in the development of the IPF ... is in Phase III stage, 15 are in Phase II stage, 12 ...
(Date:3/24/2017)... March 24, 2017 A ReportsnReports.com report says, ... growing rapidly as the global sales of Adcetris and Kadcyla have ... the antibody drug conjugates market is driven by large number of ... wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 Major ...
Breaking Medicine Technology: