nd increase risk of childhood leukemia, the researchers said.
Two groups of pregnant mice were exposed to a single high dose of dibenzoyrene, a cancer causing PAH. In addition, one group of mice was also given a high dose of a chemoprotective supplement Indole-3-carbinol or I3C.
80 percent of offspring of pregnant mice that did not receive the supplement, died early in life from T-cell lymphoma. Among those that lived, 100 percent acquired lung tumors in their middle age, the study found.
In contrast, only 50% of the mice born to those pregnant mice that also received indole-3-carbinol died from lymphoma and the number of lung tumors also was significantly lower.
"It's clear that in mice this supplement provided significant protection against lymphoma and, later on, lung cancer," Williams said.
Even though the chemoprotective effect of indole-3-carbinol seems to be real in humans, the researchers cautioned that pregnant women should not take high doses of indole-3-carbinol as it is believed that taking a high dose of indole-3-carbinol in the first trimester could cause birth defects.
However, diet high in indole-3-carbinol appears to be safe and helpful, the researchers said. Indole-3-carbinol is present in vegetables like broccoli, cabbage, cauliflower, kale, radishes, turnips and other greens.
Extensive research on Indole-3-carbinol is being done to study its chemoprotective effects against cancers- including breast cancer.
PR
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