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Pramlintide-A Boon to Restrain Fast Food Consumption

The synthetic form of pramilintide hormone previously found to produce a feeling of fullness when eating and reduce body weight, also may help curb binge eating and the desire to eat high-fat foods and sweets. Pramlintide is the synthetic form of amylin, a satiety hormone produced by the beta cells of the pancreas, which also produce insulin.

Pramlintide treatment reduces 24-hour caloric intake and meal sizes and improves control of eating in obese subjects appears in the online edition of the American Journal of Physiology-Endocrinology and Metabolism. The findings of our clinical study further suggest that satiety hormones such as amylin can exert multiple effects on human eating behavior, such as reduced intake of highly-palatable foods and reduced binge eating tendency. said Christian Weyer.

Pramlintide is marketed in the U.S. by Amylin Pharmaceuticals, under the brand name Symlin, to treat diabetes and control blood sugar. Amylin is one of several hormones secreted when eating and is known to work in partnership with insulin to regulate blood sugar. Pramlintide is also under development as a potential drug for obesity.

The study was carried out in 10 U.S. research sites and was reported by Steven R. Smith of the Pennington Biomedical Research Center in Baton Rouge, La.; John E. Blundell of the University of Leeds, United Kingdom; and Colleen Burns, Cinzia Ellero, Brock E. Schroeder, Nicole C. Kesty, Kim Chen, Amy E. Halseth, Cameron W. Lush and Christian Weyer, all of Amylin Pharmaceuticals.

Eighty eight volunteers, comprised of obese men and obese post-menopausal women, 25-60 years old, took part in the 6-week study. (Pre-menopausal females were excluded because estrogen affects hunger and eating.) Participants were divided into treatment and placebo groups at a 2:1 ratio. Neither participants nor investigators knew which subjects were receiving placebo and which pramlintide.

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