Navigation Links
Potentially Pathogenic Virus Found in Mad Cow Cells

The alternative view that a virus causes spongiform encephalopathies of the brain, such as 'mad cow' and Creutzfeldt-Jakob (CJD) disease, rather than prion// proteins, which are normally produced throughout life, is bolstered in a new study by Yale School of Medicine researchers.

The report published online January 29 in the Proceedings of the National Academy of Sciences provides evidence that a virus causes these diseases, which are manifested by devastating holes, or sponge-like spaces, in the cerebral cortex. The conclusions counter the now conventional view that abnormally folded prion proteins are infectious, and instead suggests that abnormal prion proteins are late stage footprints left by the virus.

The lead author, Laura Manuelidis, M.D., professor and section chief of neuropathology, infected cell lines with either scrapie or CJD agents. Scrapie is a degenerative disease that affects sheep and goats and is related to bovine spongiform encephalopathy, or 'mad cow' disease.

Examining the cultures using electron microscopy, Manuelidis and her co-authors found an abundance of 25 nm virus-like particles. They also found that the particles did not bind antibodies for the prion protein, indicating they were not composed of prion protein. The development of the particles was independent of pathological changes or neuronal specialization, and preparations with an abundance of these particles correlated with high levels of infectivity, whereas the presence of prion proteins did not.

'Although much work remains to be done, there is a reasonable possibility these are the long sought viral particles that cause transmissible spongiform encephalopathies,' Manuelidis said. 'The abnormal protein is probably not infectious, but is a pathological result an infectious virus binding to this host protein. Highly infectious cultures are ideal for fundamental molecular studies of this virus, as well as rapid therapeutic, preventive , and vaccination approaches.

Source: Yale University
SRM
'"/>




Related medicine news :

1. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
2. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension
3. Potentially Dangerous levels of Platinum Found in Women with Silicone Gel Breast Implants
4. WATCHs 2006 List Of Ten Potentially - Dangerous Toys
5. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
6. Newborns With Respiratory Distress Potentially Have Rare Genetic Disease
7. FDA Urgently Warns Consumers About Health Risks of Potentially Contaminated Olives
8. Research Shows That Money May Not Harbour Many Pathogenic Bacteria
9. Virus Level could Predict Cervical Cancer Risk
10. Ebola Virus - Outbreak Claims More Lives In Uganda.
11. Experimental treatment for Ebola Virus Shows promising results in mice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Yisrayl Hawkins, ... week that explains one of the most popular and least understood books in the ... cryptic and puzzling descriptions that have baffled scholars for centuries. Many have tossed it ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian ... On The Brink” is the creation of published author, William Nowers. Captain Nowers ... a WWII veteran, he spent thirty years in the Navy. Following his career ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... Wis. (PRWEB) , ... October 12, 2017 , ... ... standard products to meet the demand of today’s consumer and regulatory authorities worldwide. ... of probiotic experts and tested to meet the highest standard. , These ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)...   ZirMed Inc ., a recognized leader in cloud-based ... has been ranked #1 by its users for the seventh ... User Survey. ZirMed was recognized as the top-ranked end-to-end revenue ... centers over 200 beds and holds one of the longest ... history. ...
(Date:9/18/2017)... R.I. , Sept. 18, 2017 /PRNewswire/ ... the fields of bioinformatics and immune engineering, ... a protective avian influenza A (H7N9) vaccine. ... distantly related to seasonal influenza and presents ... rely on prior exposure to be effective. ...
(Date:9/12/2017)... Sept. 12, 2017   EcoVadis , the leading platform for environmental, ... first annual edition of its Global CSR Risk and Performance Index. The ... EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points across ... ... ...
Breaking Medicine Technology: