Navigation Links
Potentially Pathogenic Virus Found in Mad Cow Cells

The alternative view that a virus causes spongiform encephalopathies of the brain, such as 'mad cow' and Creutzfeldt-Jakob (CJD) disease, rather than prion// proteins, which are normally produced throughout life, is bolstered in a new study by Yale School of Medicine researchers.

The report published online January 29 in the Proceedings of the National Academy of Sciences provides evidence that a virus causes these diseases, which are manifested by devastating holes, or sponge-like spaces, in the cerebral cortex. The conclusions counter the now conventional view that abnormally folded prion proteins are infectious, and instead suggests that abnormal prion proteins are late stage footprints left by the virus.

The lead author, Laura Manuelidis, M.D., professor and section chief of neuropathology, infected cell lines with either scrapie or CJD agents. Scrapie is a degenerative disease that affects sheep and goats and is related to bovine spongiform encephalopathy, or 'mad cow' disease.

Examining the cultures using electron microscopy, Manuelidis and her co-authors found an abundance of 25 nm virus-like particles. They also found that the particles did not bind antibodies for the prion protein, indicating they were not composed of prion protein. The development of the particles was independent of pathological changes or neuronal specialization, and preparations with an abundance of these particles correlated with high levels of infectivity, whereas the presence of prion proteins did not.

'Although much work remains to be done, there is a reasonable possibility these are the long sought viral particles that cause transmissible spongiform encephalopathies,' Manuelidis said. 'The abnormal protein is probably not infectious, but is a pathological result an infectious virus binding to this host protein. Highly infectious cultures are ideal for fundamental molecular studies of this virus, as well as rapid therapeutic, preventive , and vaccination approaches.

Source: Yale University
SRM
'"/>




Related medicine news :

1. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
2. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension
3. Potentially Dangerous levels of Platinum Found in Women with Silicone Gel Breast Implants
4. WATCHs 2006 List Of Ten Potentially - Dangerous Toys
5. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
6. Newborns With Respiratory Distress Potentially Have Rare Genetic Disease
7. FDA Urgently Warns Consumers About Health Risks of Potentially Contaminated Olives
8. Research Shows That Money May Not Harbour Many Pathogenic Bacteria
9. Virus Level could Predict Cervical Cancer Risk
10. Ebola Virus - Outbreak Claims More Lives In Uganda.
11. Experimental treatment for Ebola Virus Shows promising results in mice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... ... Male Fertility & Sexual Medicine Specialists, in collaboration with the Fertility Center of ... male fertility care: PESA (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular sperm ...
(Date:6/26/2017)... ... June 26, 2017 , ... If ... are seeing lots of red these days. According to recent estimates, 75 – ... from medical coding errors(1). Some studies point to Electronic Health Records (EHR) with ...
(Date:6/25/2017)... ... ... Republicans in the United States Senate on Thursday released their version of ... differs significantly from the American Health Care Act, which the House passed in May, ... will have to take up the Senate version as-is, if it passes. , The ...
(Date:6/24/2017)... ... June 24, 2017 , ... ... testing for medications in select Florida and Texas doctors' offices and clinics. This ... new application of genetic testing recognizes the role genes play in determining an ...
(Date:6/23/2017)... Providence, RI (PRWEB) , ... June 23, 2017 ... ... Community Care Network today announced the launch of Care Management Alerts and Dashboards, ... for 140,000 patients throughout Rhode Island. , RIQI’s Care Management Alerts and Dashboards ...
Breaking Medicine News(10 mins):
(Date:6/14/2017)... 2017 The Bio Supply Management Alliance (BSMA) ... Fremont and the Biomedical Manufacturing Network to ... California by providing a platform ... fostering workforce development. The primary focus of this alliance ... as well as small and mid-sized biomedical companies. ...
(Date:6/12/2017)... SEATTLE , June 12, 2017 Kineta, Inc., ... today announced Kineta Vice President of R&D and ... at the Pandemic Preparedness for the Northwest and Beyond ... be held on June 14, 2017 from 8:30-10:30 AM PDT ... Dr. Bedard will be joined ...
(Date:6/9/2017)... AirXpanders, Inc. (ASX: AXP) (AirXpanders or Company), ... sale and distribution of the AeroForm® Tissue Expander System, ... commercial roll-out in the United States ... hundred (100) medical institutions and health systems, located throughout ... alternative for women who choose reconstructive surgery following a ...
Breaking Medicine Technology: