Navigation Links
Potentially Pathogenic Virus Found in Mad Cow Cells

The alternative view that a virus causes spongiform encephalopathies of the brain, such as 'mad cow' and Creutzfeldt-Jakob (CJD) disease, rather than prion// proteins, which are normally produced throughout life, is bolstered in a new study by Yale School of Medicine researchers.

The report published online January 29 in the Proceedings of the National Academy of Sciences provides evidence that a virus causes these diseases, which are manifested by devastating holes, or sponge-like spaces, in the cerebral cortex. The conclusions counter the now conventional view that abnormally folded prion proteins are infectious, and instead suggests that abnormal prion proteins are late stage footprints left by the virus.

The lead author, Laura Manuelidis, M.D., professor and section chief of neuropathology, infected cell lines with either scrapie or CJD agents. Scrapie is a degenerative disease that affects sheep and goats and is related to bovine spongiform encephalopathy, or 'mad cow' disease.

Examining the cultures using electron microscopy, Manuelidis and her co-authors found an abundance of 25 nm virus-like particles. They also found that the particles did not bind antibodies for the prion protein, indicating they were not composed of prion protein. The development of the particles was independent of pathological changes or neuronal specialization, and preparations with an abundance of these particles correlated with high levels of infectivity, whereas the presence of prion proteins did not.

'Although much work remains to be done, there is a reasonable possibility these are the long sought viral particles that cause transmissible spongiform encephalopathies,' Manuelidis said. 'The abnormal protein is probably not infectious, but is a pathological result an infectious virus binding to this host protein. Highly infectious cultures are ideal for fundamental molecular studies of this virus, as well as rapid therapeutic, preventive , and vaccination approaches.

Source: Yale University
SRM
'"/>




Related medicine news :

1. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
2. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension
3. Potentially Dangerous levels of Platinum Found in Women with Silicone Gel Breast Implants
4. WATCHs 2006 List Of Ten Potentially - Dangerous Toys
5. Jefferson Physicians Report on Potentially Fatal Complication of Heart Attack
6. Newborns With Respiratory Distress Potentially Have Rare Genetic Disease
7. FDA Urgently Warns Consumers About Health Risks of Potentially Contaminated Olives
8. Research Shows That Money May Not Harbour Many Pathogenic Bacteria
9. Virus Level could Predict Cervical Cancer Risk
10. Ebola Virus - Outbreak Claims More Lives In Uganda.
11. Experimental treatment for Ebola Virus Shows promising results in mice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out of ... verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. ... throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... DUBLIN , June 27, 2016 Jazz ... the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act ... proposed acquisition of Celator Pharmaceuticals, Inc. ("Celator"; Nasdaq: ... 11:59 p.m. (Eastern Daylight Time). As previously ... entered into a definitive merger agreement under which Jazz ...
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
Breaking Medicine Technology: