Navigation Links
Potential Target for Leukemia Treatment

Cincinnati Children’s Hospital Medical Center today announced the publication of pioneering research identifying the crucial role // and novel mechanism of action of the protein RhoH GTPase in the development and activation of cells critical to the immune system. The findings, along with other studies, suggest that RhoH GTPase may provide a target for therapeutic intervention in some types of leukemia.

The paper describes detailed genetic and biochemical studies undertaken by researchers in the Division of Experimental Hematology and the Division of Immunobiology. The investigators succeeded in identifying a crucial role for RhoH GTPase in the development of thymocytes and activation of T-lymphocytes, both key processes in immune cell development. In addition, the researchers uncovered a novel mechanism for regulating RhoH activity, which may have broad implications in improving researchers’ understanding of the mechanism of action of the Rho GTPase protein family and provide a potential target for leukemia drug development.

“We continue to make important progress in deciphering the molecular processes involved in the development and maintenance of the immune and blood system and how disruption of key proteins may contribute to leukemia,” said David A Williams, M.D., Director of Experimental Hematology, Cincinnati Children’s. “Through a collaboration with Ohio State University Comprehensive Cancer Center, we are now focused on translating these findings into developing new ways to target the protein as a novel approach to treating hematological malignancy.”

The development of mature white blood cells, including lymphocytes, is a highly complex process involving cell growth as well as specific genetic and biochemical steps. Disruption of this process is associated with diseases such as leukemia.

RhoH GTPase is specific to blood-forming cells. Experiments have shown that its alteration affects several key steps in the g rowth and development of white blood cells. Moreover, clinical samples have implicated RhoH GTPase as a factor in leukemia and lymphoma. Further work is ongoing to decipher the specific mechanism of regulation and the function of RhoH GTPase in the development of white blood cell populations.

Source-NewswiseSRM
'"/>




Related medicine news :

1. Potential New Cancer Gene Identified
2. Lack of Smell And Its Potential Risks
3. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years
4. The Potential Of Cadaver Transplantation Programme In India
5. Another Potential Of Stem Cells Discovered: Used For Growing Cartilage
6. Yoga Guru Ramdev Invited to Tap Ayurveda Potential by Jharkhand Govt
7. A Protein In Yoghurt Has The Potential To Fight E. coli
8. Gold Therapy- A Potential Treatment For Autoimmune Diseases
9. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
10. Potential Benefits Of New Nanotechnology
11. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... Derrin Doty Group has ... of Bremerton, Port Orchard and communities west of Seattle. The insurance provider’s caring team ... local girl who died suddenly due to complications from the flu, that they have ...
(Date:5/5/2016)... ... May 05, 2016 , ... A recent survey by the ... challenges in getting employees to understand and use the free preventive care benefits available ... leading non-profit business groups of large, self-insured public and private employers, MBGH found that ...
(Date:5/5/2016)... ... 05, 2016 , ... Standard Process Inc. announces ... United States. The whole food nutrient solutions company can help veterinarians grow their ... and horse owners’ peace of mind. With the increased support, veterinarian customers can ...
(Date:5/5/2016)... , ... May 05, 2016 , ... The 2016 Nike ... Derek Pittman, along with his university coaching staff. Together they bring their winning Vandals ... sessions run for youth players ages 5-13, and high school players. Session dates are ...
(Date:5/5/2016)... ... May 05, 2016 , ... Chronic stress can have a ... it can weaken the immune system and increase inflammation, both of which raise the ... the adult congenital heart disease program at Harvard-affiliated Massachusetts General Hospital. Chronic stress also ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... , May 5, 2016 Endo International plc (NASDAQ: ... of Douglas S. Ingram , former president of Allergan, ... Todd B. Sisitsky , managing partner of TPG Capital, to ... "Endo recently embarked on ... enhance and expand the Board,s capabilities. Doug and Todd are ...
(Date:5/5/2016)... May 5, 2016 Research and Markets has ... in Top 5 EU Markets"  report to their offering.  ,     ... provides information on the current Positron Emission Tomography (PET) scanner ... (T5 EU), which includes France , ... Spain and the United Kingdom ...
(Date:5/4/2016)... -- Compass Diversified Holdings (NYSE: CODI ) ("CODI," ... middle market businesses, announced today its consolidated operating results ... First Quarter 2016 Highlights , Generated Cash ... Flow") of $13.6 million for the first quarter of ... for the first quarter of 2016; , Paid ...
Breaking Medicine Technology: