Navigation Links
Potential New Therapeutic Target for Asthma, Allergies and Cancer

Virginia Commonwealth University researchers have identified how a bioactive molecule involved with allergy, inflammation and cancer is transported out of mast cells, according to findings //published online this week in the Proceedings of the National Academy of Sciences.

Mast cells are specialized cells that react to allergy-causing agents by releasing substances that trigger the body’s allergic response, leading to conditions like asthma and hives. Among the molecules released by mast cells that participate in the allergic response is sphingosine-1-phosphate. This molecule is also implicated in cancer.

The work by the VCU investigators opens up a new approach to treating asthma, which affects about 15 million Americans and is increasing in incidence and mortality, especially among African-Americans. It also has implications for other allergic disorders and for cancer in terms of developing drugs that inhibit the transport of SIP out of cells.

Sarah Spiegel, Ph.D., professor and chair, VCU Department of Biochemistry, and colleagues reported how S1P, which also regulates many important physiological functions in cells, is transported out of mast cells. S1P is produced by all cells and secreted by some cells into the circulation where it can bind to specific S1P receptors. Until now, researchers have not known the mechanism by which S1P is transported out of cells.

“Our study shows that mast cells can use a special kind of transporter that has long been known to be used by cancer cells to push anti-cancer drugs out and help them survive the treatment,” said Spiegel. “Our study is the first to establish a mechanism by which S1P can be exported out of mast cells and perhaps by cancer cells as well.”

In previous research, Spiegel’s team found that S1P levels are significantly elevated in fluid collected from the lungs of asthmatic patients after exposure to an allergen. Those findings led Spiegel’s team to beli
'"/>




Page: 1 2

Related medicine news :

1. Potential New Cancer Gene Identified
2. Lack of Smell And Its Potential Risks
3. New Blood Thinner Pill - First Potential Alternative to Warfarin in 50 years
4. The Potential Of Cadaver Transplantation Programme In India
5. Another Potential Of Stem Cells Discovered: Used For Growing Cartilage
6. Yoga Guru Ramdev Invited to Tap Ayurveda Potential by Jharkhand Govt
7. A Protein In Yoghurt Has The Potential To Fight E. coli
8. Gold Therapy- A Potential Treatment For Autoimmune Diseases
9. Whirlpool Bath Tubs Contain Potentially Lethal Bacterial Strains
10. Potential Benefits Of New Nanotechnology
11. Hormone Can Foretell Presence Of Potentially Fatal Pulmonary Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Potential New Therapeutic Target for Asthma Allergies and Cancer

(Date:7/3/2015)... (PRWEB) , ... July 03, 2015 , ... Jennifer Renee ... First Choice Emergency Room , the largest network of independent freestanding emergency rooms in ... facility medical director of our Sienna Plantation facility,” said Executive Medical Director of First ...
(Date:7/3/2015)... , ... July 03, 2015 , ... " Selfie on ... which features the latest and coolest technology products available to consumers. Amanda Forstrom, a ... how these selfie sticks are great for documenting memories. , Almost every smartphone has ...
(Date:7/3/2015)... ... 03, 2015 , ... Every year, One-to-1 Fitness and the Red Deer ... the Red Deer community with free fitness training and indoor fitness boot camp classes ... and entertainment raised thousands of charity dollars and ended with a $10,000 donation to ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to ... the first sweetFrog store located in Mississippi. The premium frozen yogurt chain was listed ... The store, located at 104 Railroad Avenue, New Albany, MS 38652, will have a ...
(Date:7/2/2015)... ... July 02, 2015 , ... sweetFrog Enterprises, LLC. is pleased to announce the ... sweetFrog store located in the Lone Star State. The premium frozen yogurt chain was ... , The store, which opened July 1 at Duke’s Travel Plaza, is located at:, ...
Breaking Medicine News(10 mins):Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Learn How to Take Selfies like Kendall Jenner 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 2Health News:Red Deer Fitness Studio Raises $10,000 for Charity Organization with 24-Hour Train-a-Thon 3Health News:sweetfrog Opens First Location in Mississippi 2Health News:sweetFrog Expands Texas Footprint with Location in Canton 2
... seemed to suggest that supplementing the diet with vitamin ... a study published In Journal Of American Medical association, ... be something very different. ,The researchers had ... Evaluation or HOPE centers between 1993 and 1999, and ...
... the fishes contains a property that may cure inflammatory conditions ... in a diet supplemented by low doses of aspirin is ... case of absence of fish, a supplement of fish oil ... shown previously that omega-3 fatty acids in conjunction with daily ...
... that lowering LDL cholesterol (“bad” cholesterol) to below ... a // cholesterol-lowering drug is safe and results in ... disease patients. They initially took 10 milligrams of atorvastatin ... to 130 milligrams per deciliter a day or lower. ...
... have been conducted to see whether antihypertensive strategies ... // are superior to older treatments with beta-blockers ... calcium channel blocker amlodipine with or without the ... or without the diuretic bendroflumethiazide. ,The trial ...
... stem cell research that will help in numerous therapies using ... growing human embryonic stem cells in the laboratory. ... important role in regeneration of cells for therapeutic use. However, ... live animal cells and serum and run the risk of ...
... issue of Journal of American Medical Association, researchers have pointed ... delaying the vaccination schedules of the children resulting in increase ... ,According to the latest study, most of the vaccines ... of age in children often gets delayed due to a ...
Cached Medicine News:
(Date:7/4/2015)... 4, 2015 Adding SIR-Spheres® ... with unresectable metastatic colorectal cancer in the liver ... Patients with unresectable metastatic colorectal cancer ... experienced the greatest improvement in Progression-Free Survival (PFS) ... Y-90 resin microspheres to a current first-line chemotherapy ...
(Date:7/3/2015)... Mexique, July 3, 2015 ... les épidémies que sont l,hypertension, le diabète et ... de plateformes éducatives gratuites et d,une conférence majeure ... http://photos.prnewswire.com/prnh/20150630/227033 ) , Les ... ligne , Prendre en charge l,hypertension en ...
(Date:7/3/2015)... Redwood Pharma AB has entered ... operating in both the US and China ... supramolecular hydrogel technology in its lead chronic Dry ... The Broda technology offers many unique competitive benefits. At ... and with low concentrations of polymer the system can ...
Breaking Medicine Technology:New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 2Lutter contre trois maladies chroniques majeures en Amérique latine grâce à la formation médicale 3Redwood Pharma Licenses Novel Hydrogel Drug Delivery Technology From Broda Technologies 2
... Healthcare Products, Inc., (NASDAQ: AHPI ) reported ... hospitals and government entities still suffering from recession-driven budget cuts. ... per basic and diluted share, for the 2011 fiscal year compared ... per share, for the previous year. For the quarter, ...
... Sept. 2, 2011 Sigma-Aldrich Corporation (NASDAQ: ... conferences in September: KeyBanc Capital Markets ... 13, at the InterContinental, Boston, MA, presenting at 9:00 ... Wednesday, September 14, at the Grand Hyatt, New York, ...
Cached Medicine Technology:Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 2Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 3Allied Healthcare Reports Profitable Quarter and Year Despite Lingering Effects of Recession 4Sigma-Aldrich Corporation to Present at Upcoming Investor Conferences 2
... orthopedic trauma procedures. Part of the ... trauma table top provides a complete, ... positioning and provides for skin or ... hip pinnings; femur, supine or lateral ...
... ElectroMagnetic Field (PEMF) bone growth stimulation delivered ... for long bone and small bone nonunions. ... orthopedic brace, or clothing without lessening its ... one compact, lightweight unit including success rates ...
Guardsman Femoral Interference Screw is specifically designed for endoscopic femoral fixation where graft protection is needed....
BioScrew® Bio-Absorbable Interference Screws and Delivery System Clinically equivalent to metal interference screws....
Medicine Products: