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Potential Key to Brain Blood-Flow Disorders Explored by Scientists

Scientists at University of Vermont have uncovered the possible causes for brain disorders such as stroke, migraine, and Alzheimer’s disease. Their findings were// published November 1, 2006 in the prestigious journal Nature Neuroscience.

The cellular process is responsible for signaling regional blood flow changes in the brain. To function properly, the brain needs to receive an uninterrupted supply of oxygen and glucose, which is provided through an intricate network of blood vessels in the brain.

Different parts of the brain are engaged by every activity, such as analytical thought, piano playing, seeing, hearing, walking, and these regions then require a rapid elevation of blood flow to meet the increased metabolic needs of the relevant brain cells (neurons). Though this cellular activity can be visualized in modern-day functional brain scans, the mechanisms by which these neurons signal blood vessels to dilate and increasing blood flow remain largely unknown, and are central to understanding brain function.

The diameter of blood vessels in the brain can be modulated by extracellular potassium, a common element present inside and outside all cells of the body. Such modulation of vessel diameter permits changes in blood flow to occur in the brain, as well as in other organs and tissues.

With this knowledge, lead study author Mark Nelson, Ph.D., professor and chair of pharmacology at the University of Vermont, set out to determine whether the diameter of cerebral blood vessels in the brain could be modulated under physiological conditions by external potassium ions. To accomplish this, he and his research team studied the communication that takes place between neurons and blood vessels in mouse and rat brains.

The research team discovered early on that neuronal activity appeared to be communicated to the blood vessels through intermediary cells known as astrocytes.

Astrocytes, which compris
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