Navigation Links
Possible location of lung cancer genes found

Researchers at Dana-Farber Cancer Institute and collaborating institutions have found sections of the // chromosomes of lung cancer cells where cancer-related genes may lurk.

In a study in the July 1 issue of the journal Cancer Research, the researchers used single nucleotide polymorphism (SNP) array technology, which focuses on the building blocks of individual genes, to identify regions of chromosomes where genes were either left out or multiplied over and over – mistakes that are often associated with cancer. In this effort, SNP (pronounced "snip") arrays have been used to find gene-copy errors in lung cancer cells.

Senior author of the study Matthew Meyerson, MD, PhD, of Dana-Farber said:. "In a previous study, we showed that SNP arrays offer a unique way of locating copy-number changes in cell chromosomes and of determining when genes on a pair of chromosomes are mismatched. The current study demonstrates that high-resolution SNP technology is powerful enough to identify copy-number alterations that previously hadn't been found in lung cancer cells."

Working with 70 specimens of lung cancer tissue and 31 laboratory-grown lines of lung cancer cells, the investigators used high-resolution machinery to scan the cells' chromosomes in 115,000 locations. They found several areas that had already been identified as having copy-number errors, plus five new ones –– two where genes had been deleted, and three where they had been highly over-copied.

The next step will be to identify the specific genes involved in these alterations. That, in turn, could lead to new diagnostic tests and treatments for lung cancer, by far the most common form of cancer in the United States, and one of the most difficult to treat.

There is increasing evidence that therapies aimed at specific gene abnormalities can be effective in treating cancer. Last year, for example, Meyerson, demonstrated that the drug Iressa shrank tumors in patients with the most common form of lung cancer who carry an abnormality, or mutation, in a single gene.

Meyerson, points out that the presence of copy-number changes doesn't guarantee that genes in the identified regions are involved in cancer. "We'll need to characterize the genes in these regions in detail to understand their role and whether they are cancer-causing or cancer-preventing genes," he remarks.

Bill Schaller william_schaller@dfci.harvard.edu 617-632-5357 Dana-Farber Cancer Institute Extracts of the news from http://www.eurekalert.org
'"/>




Related medicine news :

1. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
2. Possible benefits of Hormone Replacement Therapy
3. Low Protein Levels A Possible Indicator For A Miscarriage
4. Cure For Persistent Oral Fungal Problem May Be Possible
5. Transfer Of Rabies Virus Possible From Organ Donor To Recipient
6. Treatment May Be Possible For Degenerative Brain And Spinal Cord Disease
7. Its Possible To Grow Bone To Replace The Damaged Bone
8. Healthy At 50: Possible?
9. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors
10. Safe Driving Is Possible For Older People If They Are Prepared
11. It Is Possible To Detect Alzheimers Early
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2017)... ... 21, 2017 , ... Following the tragic and widely publicized death of Rory ... require that hospitals follow a protocol to quickly identify and treat the condition. ... such steps would have saved Rory or anyone else’s life. , Now, five ...
(Date:5/19/2017)... (PRWEB) , ... May 19, 2017 , ... In a ... PlushBeds , a luxury online mattress company that specializes in natural and organic ... nation’s leading grassroots autism organization) for every unique share their recent viral Facebook ...
(Date:5/19/2017)... Jupiter, FL (PRWEB) , ... May 19, 2017 ... ... will feature RawTrition’s BioEnergy in an upcoming episode of Innovations with Ed Begley, ... New Jersey, RawTrition is the distributor of a clean, organic dietary supplement made ...
(Date:5/19/2017)... ... May 19, 2017 , ... Springfield, Vermont-based law firm of ... " Ten Good Reasons To Hire An Experienced Personal Injury Attorney, " the article ... accident or injury. As the article says. if someone is injured due to ...
(Date:5/19/2017)... ... May 19, 2017 , ... The Miller Agency, a Jacksonville ... and business owners in the region, is embarking on a cooperative charity event ... families. , Multiple sclerosis (MS) is a demyelinating disease that affects the insulation ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... LAWRENCE, Mass. and SAN DIEGO ... of Obstetricians and Gynecologists (ACOG) 2017 Annual Clinical and ... of single-use, self-contained, illuminating medical devices, today announced the ... size of its OfficeSPEC and ER-SPEC ... large, the addition of extra-small and extra-large sizes makes ...
(Date:5/3/2017)... , May 3, 2017  Kalorama Information notes ... nine percent next year and this is projected ... hematopoietic stem cell (HSCT) or bone marrow transplants ... technologies are well-suited for this task. This according ... publisher Kalorama Information. The various PCR-based methodologies, Sanger ...
(Date:5/2/2017)...  CIVCO Radiotherapy, the leading provider of high ... Nat Geissel has been named president. ... has served as vice president of marketing and ... manager, and most recently, executive vice president and ... of what CIVCO Radiotherapy and its predecessors have ...
Breaking Medicine Technology: