Navigation Links
Possibility Of Treatment For Permanent Hearing Loss

Researchers from University of Iowa and Okayama University, Japan, have reported a possible cure// for a kind of permanent hearing loss from parallel studies with animals.

The researchers gave a genetically deafened mouse interfering RNA that specifically prevents a gene from being expressed that would otherwise cause deafness. By preventing its expression, they had been able to prevent the deafness. Even at this early stage, the results are important feels the researchers because they point to other options for people who have hearing loss other than hearing aids or cochlear implants.

The gene-silencing technique used by the UI team is called RNA interference (RNAi) and works specifically against genetic conditions caused by a so-called dominant negative mechanism -- when a single copy of the mutant gene is sufficient to cause disease because the protein from the faulty gene has a dominant adverse effect over the protein from the normal gene. Several human forms of inherited deafness, including the one mimicked by the UI mouse model, are caused by a dominant negative mechanism.

To test the gene-silencing technique, the researchers had introduced a mutated gene that causes deafness in humans into the inner ear of mice. This gene acted through a dominant negative mechanism, and the mice had moderate hearing loss. Then they had simultaneously introduced the mutant gene and a short piece of interfering RNA specifically designed to silence the gene. Standard hearing tests, similar to those used on newborn babies, confirmed that the treated mice were able to hear.

The results said that RNA interference was not only successful but also highly specific. Despite the fact that the mouse and the human gene differed by only two nucleotides over the short stretch of gene targeted by the RNAi, the mutant human gene was silenced while the normal mouse gene was unaffected.

With a view to someday moving this therapy to humans , the researchers also developed a non-invasive strategy to deliver the RNAi. A small piece of foam soaked in a solution containing the interfering RNA was placed against the membrane covering one opening into the inner ear of the mice. The slightly porous membrane allowed the interfering RNA to diffuse into the inner ear cells.

Source: Newswise

Medindia on Hearing Loss: Further information:

Hearing loss: Losing the ability to hear sounds may be due to infection, blockage or damage to the ear. Other kinds of hearing loss may be due to damage to the pathway through which the sound waves travel from the hair cells of the inner ear to the auditory nerves. The probable causes of this may be age, disease, infections, tumor or stroke.

RNAi: RNA interference is a technique of gene silencing that is used to study the effect of absence of a gene, by causing disruption to its expression, on an animal or a plant.


'"/>




Related medicine news :


1. Possibility of Link Diabetes with Iron
2. The Possibility Of Fighting HIV with Another Virus Questioned
3. New Hair in 15 Days Could Now Be A Possibility Say Researchers
4. Possibility Of Regaining Speech After Tongue, Voice Box Removal
5. Mumbai Alert: Possibility Of An Epidemic Outbreak
6. Limb Regeneration In Humans: A Future Possibility
7. Controversy: Malaria Vaccine - Future Possibility Or Just A Dream?
8. Possibility Of Bird Flu Outbreak In South Africa Ruled Out
9. Possibility Of A Meningococcal Outbreak In NSW
10. Advances in Treatment of Cataracts
11. Recommendations for Treatment of Blood Pressue
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... Petersburg, FL (PRWEB) , ... February 11, 2016 ... ... providers and advocates will discuss how to improve care by making data on ... pediatric heart disease. The Summit on Transparency and Public Reporting of Pediatric and ...
(Date:2/11/2016)... ... , ... In a new paper published in the latest ... J. Rohrich, and colleagues, examine and underscore the importance of upper lateral cartilage ... addressing this vital area. , The upper lateral cartilage in rhinoplasty, refers to ...
(Date:2/11/2016)... ... February 11, 2016 , ... veEDIS Clinical ... technology, with highly adaptable algorithms, has been updated to help Emergency Department physicians ... symptoms consistent with Zikas and a travel history to affected regions, or potential ...
(Date:2/11/2016)... ... February 11, 2016 , ... "What holds you ... Ray Clarke poses a question as a challenge for his readers to examine ... in the Being" (published by Partridge Singapore), Clarke explores the subject with more ...
(Date:2/11/2016)... ... , ... Life is known for throwing curves. It’s thrown quite a few ... a year to play softball to raise money through Sun Health Foundation ... players who competed in this year’s softball tournament share a history of heart problems, ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Kindred Biosciences, Inc. (NASDAQ: ... and improving the lives of pets, today announced the ... the New Animal Drug Application (NADA) for Zimeta™ (dipyrone ... study (KB0120) of Zimeta for the control of pyrexia ... --> --> The ...
(Date:2/11/2016)... -- Potrero Medical, Inc., the developer of the Accuryn™ critical ... George M. Rapier, III , MD, to its Board ... WellMed is one of the nation,s largest physician owned practice ... Texas and Florida ... internal medicine practice, he has been instrumental to the company,s ...
(Date:2/11/2016)... 11, 2016  AfterPill.com is reporting that this week,s ... for all women who are at risk of unintended ... year and raises the risks of unprotected sex in ... According to the Guttmacher Institute, there are 43 ... child-bearing age, who have sex without the intention of ...
Breaking Medicine Technology: