Navigation Links
Polymer Molecule Layered On Carb Molecule to Increase Sensitivity

According to a new research at the Pacific Northwest National Laboratory, scientists have developed a new biosensor which is highly sensitive in detecting// blood sugar levels. They have taken a polymer (protein) and layered it on the carbon nanotube to increase the detection capacity.

This configuration can accommodate a wide range of applications, from ultra-precise blood-sugar monitoring to infectious-agent detection, said Yuehe Lin, who led the research at the Department of Energy campus' W.R. Wiley Environmental Molecular Sciences Laboratory.

The technique, described in the current (April) Journal of Nanoscience and Nanotechnology, enables enzymes, with the help of a long, noodle-like polymer molecule, to self-assemble layer-by-layer on a single carbon nanotube.

Lin and co-author Guodong Liu, a postdoctoral fellow in Lin's group, coaxed electrostatic clinginess in a polymer and an oppositely charged protein-enzyme, in this case glucose oxidase, which reacts in the presence of blood sugar. The catalyzed products from the reaction ping the carbon nanotube; if the tube is connected to an electrode, the tube will carry a signal that corresponds precisely with the amount of glucose detected. The first polymer binds to the carbon nanotube. Enzymes are attracted to the polymer, leaving an outer layer for the next polymer of opposite charge to cling to, and so on.

An individual strand coated with one to six layers ranges from 30 nanometers to about 50 nanometers thick. "Each polymer layer is porous," Lin said. "This allows the glucose to diffuse in and come into contact with the enzymes." "The polymers trap the enzymes in place," Liu said. "You can go up to five or six layers to improve the sensitivity of the detector, but after that, the more enzyme layers" inhibit diffusion of the glucose.

Now that the glucose enzyme biosensor has passed the test, Lin said, it should be possible to build a similar sensor using other enzymes that react specifically with other biological chemicals, environmental agents or even microbes and their toxic byproducts. Lin and colleagues also reported, in February issue of Analytical Chemistry, having used a similar technique to construct sensors for nerve agents. The source is Eurekalert.


Related medicine news :

1. Fine Polymer Scaffolding – a Boon for Skin Reconstructio
2. New Molecule that can stop the growth of Viruses
3. Puberty may be due to GPR54 gene and KiSS-1 Molecule
4. Molecule responsible for muscle repair identified
5. Molecule aids fight E. Coli Infections
6. Molecule That Aids Bacterial Infections Identified
7. Molecule Behind Multiple Sclerosis Discovered
8. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
9. Scientists Discover Prostate Cancer Triggering Molecule
10. Passion Fizzling Out? Blame The “Love Molecule
11. Sensor Can Detect "Unhealthy" Molecules In Breath
Post Your Comments:

(Date:11/27/2015)... ... November 27, 2015 , ... Keeping in mind ... mental health and wellness consultation, has collaborated with a leading web-based marketplace for ... gap experienced by parents and bring advice from parenting experts within their reach. ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... most successful and prominent nonprofit healthcare organizations in the country. They have overseen ... various organizations, and helped advance the healthcare industry as a whole through their ...
(Date:11/27/2015)... Francisco, California (PRWEB) , ... November 27, 2015 , ... ... Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of Joplin's ... at the Canterbury House at the University of Michigan in Ann Arbor. The According ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients ... central Michigan, have come together on Thanksgiving Day to share the things that ... viewing on the Serenity Point YouTube channel, patients displayed what they wrote on ...
(Date:11/26/2015)... Cambridge, ON (PRWEB) , ... November 26, 2015 ... ... availability of a real-time eReferral system for diagnostic imaging in the Waterloo region. ... mammography, BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... ) ... "Global Brain Monitoring Devices Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:11/25/2015)... AAIPharma Services Corp./Cambridge Major Laboratories, Inc. ... $15.8  Million to expand its laboratories and global ... The expansion will provide additional office space and ... of the pharmaceutical and biotechnology markets. ... up to 40,000 square feet of expanded development ...
Breaking Medicine Technology: