w study, published in the April 25 issue of the Journal of the American Medical Association, included surveillance data from the beginning of 1995 through 2006.
The researchers found that within three years of the introduction of the vaccine, the overall rates of invasive pneumococcal disease in Alaskan Native children under age 2 was down by 67 percent.
However, when the researchers compared the two-year periods of 2001-2003 to 2004-2006, they saw an 82 percent increase in the rate of overall invasive pneumococcal disease in Alaskan Native children under 2. For strains not covered by the vaccine, the rate jumped by 140 percent compared to the pre-vaccine period.
One strain in particular, serotype 19A, was responsible for almost one-third of the non-vaccine covered disease, according to the study.
Dr. Katherine Poehling, a pediatrician at Brenner Children's Hospital at Wake Forest University School of Medicine in Winston-Salem, N.C., said, "The serotype replacement is occurring to a greater extent in this (Alaskan Native) population, but it will happen in others."
Singleton said that potential ways to reduce the incidence of disease were good hand-washing, breast-feeding your baby if you can, and delaying putting children into day care if possible.
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