Navigation Links
Platelets May Be The Source Of Gene Regulations

Researchers from University of Utah School of Medicine had reported that a key process in gene regulation could occur in human platelets. These are unique cells that are unusual because they don’t have a nucleus // (anucleate).

Scientists long have thought the transformation of pre-mRNA into mature mRNA—called splicing—happens only in a cell’s nucleus. But using stem cells from human umbilical cord blood to engineer the precursor cell that forms platelets and platelets isolated from the blood of study subjects, the Utah researchers found that splicing also takes place in the cytoplasm of circulating platelets.

The U researchers, who report their findings in the August edition of the journal Cell, also identified the pre-mRNA in blood platelets that codes for Interleukin 1? (IL-1?), a key protein in an ancient molecular system that plays major roles in inflammation, defense against infection, organ development, and disease. When blood platelets are activated through biochemical signals in response to injury, the IL-1? pre-mRNA is processed into the mature mRNA and then directs production of the critical inflammatory protein.

Finding that platelets can splice the IL-1? pre-mRNA was completely unexpected and emerged while the researchers were engaged in earlier studies of how platelets communicate with certain leukocytes (white blood cells). During that investigation the scientists had found evidence of platelets making new proteins, which led them to pursue the mechanisms that are involved.

Researchers theorize that splicing outside the nucleus is one of a number of intricate ways the body maintains more precise control over gene expression. Many of these control mechanisms are just coming to light.

Source: Newswse
'"/>




Page: 1

Related medicine news :

1. Quality Platelets and Improved Blood Availability No Longer a Pipe Dream
2. Startling Expose – Physicians Often Have No Regular Source Of Health Car
3. Indian Cherry: Richest Source of Vitiamin C
4. Urban Monkeys Source Of Virus Infections
5. Parents – Teen’s Most Reliable Source for Sex Educatin
6. Fruit And Vegetable Peels Are Rich Source Of Potent Antioxidants
7. New York- A haven For the Distressed or a Source of Distress?
8. Results of Clinical Trials Vary According to Source of Funding
9. Source of obesity linked to eating pattern!
10. Mushrooms are Rich Source of Antioxidants
11. Bacteria Killed By Radiation Serves As an Effective Source of Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/27/2017)... MD (PRWEB) , ... July 27, 2017 , ... ... Teams of entrepreneurs will compete to form startup companies around 117 breakthrough inventions ... Heart, Lung, and Blood Institute, and National Institute of Biomedical Imaging and Bioengineering), ...
(Date:7/27/2017)... ... July 27, 2017 , ... Cremations recently surpassed traditional burials ... Association, this trend is expected to continue with over 70% of Americans projected to ... demand for new innovations that enable families to celebrate the life of a lost ...
(Date:7/26/2017)... ... 2017 , ... An inventor from Salisbury, N.C., knows the difficulties involved with ... and dignified way to keep leeches in place during therapy," she said. "That’s why ... an effective way to keep a leech in place on the skin during therapy. ...
(Date:7/26/2017)... ... July 26, 2017 , ... Written By: ... a major advancement in drug therapy for patients living with relapsing and primary ... a novel B cell targeted therapy that has been proven to significantly reduce ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... Management Solutions as part of their continued efforts to provide innovative offerings to ... the best IT resources and build dynamic, high-performing teams to address healthcare IT’s ...
Breaking Medicine News(10 mins):
(Date:7/20/2017)... -- Prime Therapeutics LLC (Prime) released this statement from its Chief ... for Clinical and Economic Review,s (ICER) public meeting ... of abuse-deterrent formulations (ADF) of opioids. Prime was the sole ... "The ICER data ... use of abuse-deterrent formulations (ADF) in opioids in terms of ...
(Date:7/14/2017)... 14, 2017 Endo International plc (NASDAQ: ENDP ... 8, 2017.  Members of its senior management team will host a ... 8:30 a.m. ET. The dial-in number to access ... (678) 509-7598, and the passcode is 45397076. Please dial in 10 ... A replay of the call will be available ...
(Date:7/13/2017)...  New York City-based market research firm Kalorama Information notes ... of.  From new products to new costs, to the threat ... completed study, Potential Pipeline Disruptors . Among ... 1.  Age-Driven Growth - True Impact Moment Arriving   ... impact the growing population and, to a more extreme extent, ...
Breaking Medicine Technology: