( e] we observed that although all of the...)Placental Protein Leads To The Onset Of Preeclampsia - Researcher Finds,Health

e] we observed that although all of the animals treated with sFlt1 exhibited telltale symptoms of hypertension and proteinuria, they did not all go on to develop symptoms of the HELLP syndrome,’ notes Karumanchi.

‘We, therefore, hypothesized that other placenta-derived proteins must be acting jointly with sFlt1 to induce vascular damage and escalate the disease to its severe form.’

preeclampsia, Karumanchi and his coauthors observed that a protein known as endoglin was significantly upregulated. (Endoglin was discovered 20 years ago in the laboratory of study collaborator Michelle Letarte at The Hospital for Sick Children, Toronto.) A co-receptor for transforming growth factor beta family proteins, endoglin is expressed on endothelial cells lining the blood vessels, and thereby plays an important role in maintaining the health and integrity of the vascular system.

‘Our further investigations revealed that the extracellular region of the endoglin protein is shed into maternal circulation,’ explains Karumanchi. ‘We discovered that this shed form -- referred to as ‘soluble endoglin’ – was circulating in very high quantities among women with severe forms of preeclampsia.’

In order to understand the protein’s biological role, the investigators next administered soluble endoglin to pregnant rats; their results showed that this protein was indeed amplifying the vascular damage mediated by sFlt1, resulting in the symptoms of severe preeclampsia.

‘What is apparently happening is that both sFlt1 and soluble endoglin are inhibiting the functions of two angiogenic growth factors – vascular endothelial growth factor [VEGF] and transforming growth factor beta,’ explains Karumanchi. ‘The diminished signaling of these growth factors in the vasculature adversely affects the health of the mother’s small blood vessels.’ The result is the onset of preeclampsia and its dangerous consequences for both mother and infant.

‘We bel
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