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Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane

elet membrane it binds to the portion of the integrin within the membrane, and subsequently perturbs another function in the clotting process downstream. "By having molecules that bind to the membrane-embedded portions of these proteins, we were able to address questions concerning the way that these proteins are regulated to cause clotting," explains co-first author Joanna Slusky, a doctoral student in the DeGrado laboratory.

"Therapeutics derived from this approach are a long way off, but this method allows us to now study these interactions that are so fundamental to the way in which cells cooperate to carry out essential functions," says Bennett. "In the future, this knowledge can provide insights for identifying novel drug targets."

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