Navigation Links
Pediatric Cancer Stem Cell Identified

Dr. Leonard Zon (Childrens Hospital Boston) and colleagues have identified the cancer stem cell for rhabdomyosarcoma, the most common soft-tissue sarcoma of childhood.

'Identifying the cancer stem cell and the evolutionarily conserved genetic programs underlying self-renewal in ERMS will likely lead to new insights into how to destroy these cell types in established malignancies,' explains Dr. Zon.

Rhabdomyosarcoma (RMS) is an aggressive cancer that arises from a primitive skeletal muscle cell called a "rhabdomyoblast". Depending upon on the histology of the cancerous cells, there are several different subtypes of RMS. Embryonal rhabdomyosarcoma (ERMS) is the most common subtype, usually found in children under 15, in the head and neck region and genitourinary tract.

Dr. Zon and colleagues have developed an animal model to identify and test therapeutic targets of human ERMS. The scientists artificially activated the RAS pathways to induce ERMS in a strain of genetically engineered zebrafish. Some transgenic zebrafish developed visible tumors by 10 days of age.

Through their model, Dr. Zon and colleagues were able to identify both an ERMS tumor-cell-of-origin and a novel genetic signature that underlies ERMS progression in zebrafish and human patients. Cancer stem cells make up only a small fraction of the overall number of cells in a tumor. However, they are capable of giving rise to other cancer cells, and thereby drive tumor growth and metastasis. To prevent recurrence and progression, effective long-term therapies must target the self-renewing population of cancer stem cells.

The zebrafish is ideally suited for use in targeted chemical genetic approaches to specifically inactivate cancer pathways we have identified in our study. Identifying drugs that inactivate these pathways in the ERMS cancer stem cell may have far reaching implications for treatment of patients with this disease.
< br>
'"/>




Related medicine news :

1. Support Services found to Dramatically Impact Pediatric Health Care
2. Pediatricians differ in their opinion of child abuse
3. New Treatment Discovered For Pediatric Cholera
4. Pediatricians Need To Talk To Parents Of Overweight Kids
5. A New Diagnostic Approach To Pediatric Interstitial Lung Disease
6. FDA Accords Priority Review For Pediatric Crohns Disease Drug
7. WHO Updates Outdated Pediatric Growth Charts
8. Pediatricians Resignations Cause Concern at Sale
9. Mental Health Providers Can Be Successfully Located With Pediatricians
10. World’s First Pediatric Laparoscopic Liver Surger
11. Pediatric Dental Care Found Wanting
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... Miami, FL (PRWEB) , ... May 31, 2016 , ... ... the wellness industry, today released ten predictions on the future of wellness, travel, spa ... CEOs of top travel, spa and beauty companies to leading economists and researchers - ...
(Date:5/31/2016)... ... May 31, 2016 , ... In his latest video, ... traits in humans. Using presidential candidate Donald Trump as an example, Kalsi describes ... “AstroNumerology is not about adding numbers up,” says Kalsi. “It is about looking ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... The Orthopaedic ... executive committee members: , David G. Lewallen, MD, began his term as president ... president. Michael L. Parks, MD, is OREF’s new president-elect. Richard F. Kyle, MD, will ...
(Date:5/31/2016)... , ... May 31, 2016 , ... Phynd Technologies, Inc. ... GA; Houston Methodist – Houston, TX and Shore Medical Center – Somers Point, NJ. ... three different, leading EHR solutions, demonstrating the breadth of Phynd’s solution and its interoperability. ...
(Date:5/31/2016)... ... ... In a recent interview on The Greenburgh Report radio show hosted by ... (1460 AM), leading medical insurance advocate Adria Goldman Gross discussed several eye-opening issues ... , During the interview with Mr. Feiner that aired on May 7, 2016, ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... New York , May 30, 2016 ... market report titled, "Advanced (3D/4D) Visualization Systems Market - ... 2016 - 2024." According to the report, the global ... 1.8 Bn in 2015 and is anticipated to expand ... to reach US$ 3.2 Bn in 2024. ...
(Date:5/30/2016)... May 30, 2016 On 28 May, ... hepatitis by 2030. At the 69 th World Health ... Viral Hepatitis Strategy, signalling the greatest global commitment in viral ... of eliminating hepatitis B and C by 2030 and includes ... will reduce annual deaths by 65% and increase treatment to ...
(Date:5/27/2016)... , May 27, 2016  A new study highlights the necessity of health literacy ... Journal of the American College of Radiology , a majority of oncology patients undergo ... Photo - http://photos.prnewswire.com/prnh/20160527/373022 ... ... Medical Diagnostic Imaging Ampronix ...
Breaking Medicine Technology: