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Pazopanib Shows Positive in Advanced Renal Carcinoma, Ovarian Cancer and Soft Tissue Sarcoma

se. Currently there is no standard treatment for such patients. Of 80 patients included in the first stage of this study, 27 (34%) achieved progression-free survival at 12 weeks.

Pazopanib was evaluated in four types of STS in the first stage of the study: leiomyosarcoma, liposarcoma, synovial sarcoma and other soft tissue sarcomas. Pazopanib demonstrated activity in all tumor types except liposarcoma, and the study is ongoing to further investigate activity in the responsive tumor types. The most common AEs recorded were hypertension, fatigue, hair color change, and nausea. Please see safety considerations below.

About pazopanib. Pazopanib is an investigational, oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-kit. Pazopanib is currently in Phase III development for the treatment of advanced or metastatic RCC, after completing patient enrollment several months ahead of schedule, and is also being studied in a number of other trials across various tumor types.


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