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Passive Smoking Makes Kids Prone To Respiratory Illness

gene are considered together, people may either have a 'GG,' 'AA' or 'AG' genotype.

The researchers found that children who had the "A" variation--either the 'AA' or 'AG' genotype--were more vulnerable to the effects of second-hand smoke.

Children with the 'A' variation who were exposed to smoke at home were 75 percent more likely to be absent from school due to illness of any kind compared to children in smoke-free homes who had the 'GG' genotype.

The effect became pronounced when it came to respiratory illness. Children with the 'A' variation who lived with two or more smokers were twice as likely to miss school due a respiratory illness compared to 'GG' children who lived in smoke-free homes. And the effect was particularly strong for lower-respiratory illness, such as chest infections. Children with the 'A' variation who were exposed to two or more smokers were four times as likely to stay home due to lower-respiratory illness than were unexposed children with the 'GG' genotype.

Chemicals found in cigarette smoke promote oxidative stress, which is involved in numerous inflammation processes in the body. TNF-alpha plays a role in those processes, and researchers suspect that variations in the TNF-alpha gene might intensify the body's inflammatory response.

(Source:ANI)
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