Navigation Links
Passive Immunotherapy Could Prevent Avian Flu from Affecting Humans

According to a pilot study conducted by Jiahai Lu, Ph.D., of the school of public health at Sun Yat-sen University said that passive immunotherapy// is the best way to treat highly pathogenic avian influenza in humans.

Passive immunotherapy uses antibodies from horses. Purified antibodies to the H5N1 strain of avian influenza are derived from horses were used against mice and it proved effective in preventing the disease. The researchers reported their findings in the journal of Respiratory Research. Passive immunotherapy is an alternative strategy used to treat H5N1 infection.

The researchers reported two experiments, both using highly purified fragment antigen binding (FAB) molecules derived from equine antibodies to the H5N1 hemagglutinin glycoprotein. In the first, they showed that the equine (horse) antibodies prevented the infection of dog kidney cells. In the second experiment, the researchers showed that the equine antibodies prevented death from H5N1 flu in infected mice, which are known to be susceptible to the H5N1 flu. The mice were divided in to 4 groups. Each group containing 10 mice. The mice were infected with 50 microliters of H5N1 virus. After 24 hours three groups of mice were injected intraperitoneally with 50, 100, or 200 mcg of the antibody preparation. The fourth group, used as controls, received 200 mcg of normal horse sera. The H5N1 infection was fatal to all the control mice.

But seven of the 10 mice which were given 50 mcg of the antibody preparation and the mice that were given higher dosages survived. Dr. Lu and colleagues reported that this method can be used until an efficacious vaccine, specific anti-H5N1 agents, and effective epidemiologic control measures for H5N1 virus infection was discovered. Dr. Lu and colleagues concluded that H5N1-specific passive immunotherapy can be used for the early treatment of avian influenza patients to reduce the severity of illness and the likelihood of H5N1 transmis sion to others. But they also said that there is a major disadvantage as in these procedure polyclonal antibodies derived from horses has the potential to cause a strong host immune response which might inhibit its use in the clinic.

Bird flu is now found in populations in Asia, Africa, and Europe. Occasionally bird flu infects humans although it is not easily transmitted between people. But health authorities are worried that the virus has the potential to become a human pandemic disease with only small genetic changes. The World Health Organization confirmed 186 cases of human infection with the H5N1 strain, of which 105 have proved fatal.


'"/>




Related medicine news :

1. Passive smoking affects respiratory system
2. Passive smoking may be harmless
3. Passive Smoking A Health Hazard Unnoticed
4. Passive Cigarette Smoking Increases Isoprostane Formation
5. Passive Smoking Makes Kids Prone To Respiratory Illness
6. Passive Immunization to prevent Bird flu infection
7. Passive smoking declared as Toxic in California
8. Passive Smoking Worsens Allergies
9. Passive Smokers may Face Higher Heart Disease Risk
10. Immunotherapy For Cancer Treatment
11. Immunotherapy Does Not Prolong Life When Skin Cancer Spreads
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia ... 1, 2017. The name change aligns the entire company with its existing ... care quality. , “We are very proud of the achievements associated with the ...
(Date:12/8/2016)... ... December 08, 2016 , ... After enjoying record-breaking attendance at ... for its 33rd Annual Issues & Research Conference, March 2-3, 2017, at ... the conference is “Persistent Challenges and New Opportunities: Using Research to Accelerate the ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input to Electronic Health ... . , Results of the comparative usability study demonstrate that a dictation-based method ...
(Date:12/8/2016)... ... December 08, 2016 , ... Mirixa Corporation , a ... other pharmacist-delivered patient care services, has announced the promotions of Karen Litsinger to ... president of sales. , Litsinger joined Mirixa in 2008 after serving as ...
(Date:12/8/2016)... ... ... With the increasing demand for dental implants, the National Association of Dental ... dentists and patients about the safety issues related to dental restorations. According to the ... is projected to reach $6.4 billion in 2018 with more than 30 million Americans ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... QUEBEC CITY , Dec. 8, 2016 /PRNewswire/ ... key US patents for improving the accuracy, reproducibility ... CD images in long and small bone orthopaedic ... proprietary approach to creating personalized orthopaedic restorations based ... create personalized orthopaedic restorations, the company harnesses the ...
(Date:12/8/2016)...  A new study by a pair of Geisinger ... therapy to treat chronic pain is not only ineffective, ... consequences, including death. Palliative care physicians ... , M.D., authored the study which provides a review ... study was published in the December 2016 edition of ...
(Date:12/8/2016)... Information products and services provider Elsevier has launched ... world,s largest abstract and citation database of peer-reviewed literature, providing the ... 5,000 publishers. The new set of metrics will improve decisions on ... adjust a journal,s editorial strategy. ... , CiteScore metrics comprise ...
Breaking Medicine Technology: