Navigation Links
Parkinson's Targets Two Distinct Brain Networks, Finds Study

A new research has found that Parkinson's disease targets two distinct brain networks in humans .

The study, carried out by David Eidelberg, MD, head of the Center for Neurosciences at The Feinstein Institute for Medical Research, and his colleagues, found that Parkinson's attacks another brain network that regulates cognitive thought and the ability to perform everyday tasks.

Eidelberg and his team measured and quantified this network of brain regions during a five-year study of newly diagnosed Parkinson's patients who agreed to be followed several times over the course of the study.

This is the first longitudinal study of Parkinson's disease using a brain scan to follow these Parkinson's network over time. The new report appears in an online version in the journal Brain, and will be published soon in a print version.

Dr. Eidelberg said that the new precise technology, to diagnose the two brain networks, could be used to measure the degenerative disease process and the person's response to treatments.

The study also shows that the standard drugs used to treat Parkinson's modify the areas that are involved in movement but not those that regulate cognition. The network that grows abnormal over time includes an called the pre-frontal cortex, known as the brain's executive secretary; organizing, planning and carrying out tasks in order of importance. It's the same region that is hard-hit in mild cognitive impairment, the precursor to Alzheimer's dementia. But Eidelberg said that the symptoms in the two diseases are quite different. But thinking that medicines used for Alzheimer's might help normalize this network, the scientists gave Parkinson's patients eight weeks of treatment, but it didn't work.

"We really don't know precisely what's going on in this newly-identified network, but we can begin to ask questions and figure it out. We don't even know whether this network can be fixed," said Dr. Eidelberg.

In 1999, the researchers recruited 15 patients with early stage Parkinson's and signed them on to get brain scans at different points all through the study. Some were on medicines and some were not. The first networks to be identified were the basal ganglia, thalamus and brain stem that regulate movement. The scans they used measured glucose metabolism - the brain's fuel - and identified areas in this motor network that showed decreased metabolic activity and some areas that had increased metabolic activity. Over time, the cognitive network became apparent. And as the disease progressed and symptoms worsened, this network also took its toll.

"The circuits are like a fingerprint of the disease. As the disease gets worse, the fingerprint is much easier to identify. The cognitive problems are real and have to be addressed. The medicines for Parkinson's don't seem to do anything to alter these networks and we need new ones to target these symptoms," Dr. Eidelberg said.

Eidelberg added that the networks could be used as biomarkers to diagnose the disease. The scientists have also developed mathematical computer models to determine how fast the disease will progress.

"These scanning techniques may be helpful in determining what treatments work and what don't," he said.


'"/>




Related medicine news :

1. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
2. Link between Constipation and Parkinsons Disease
3. Alternative therapies popular with Parkinsons patients
4. Poisonous Parkinsons molecule discovered
5. Cell transplants used to fend off Parkinsons symptoms
6. Coenzyme Q10 may reduce risk of Parkinsons disease
7. Vitamin E rich diet guards from Parkinsons
8. New hope for patients with Parkinsons disease
9. Parkinsons disease as a result of Head injuries
10. Homocysteine The Cause Of Depression In Patients With Parkinsons
11. Stopping The Progression Of Parkinsons Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Revolutionary technology includes multi-speaker listening to ... leaders in advanced audiology and hearing aid technology, has ... the world,s first internet connected hearing aid that opens ...      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) , ... firsts,: , TwinLink™ - the first dual ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: