Navigation Links
Parasitic Worms Could Be Used To Treat Bowel Disease

Researcher Linda Mansfield Michigan State University is a part of a national team of scientists engaged in looking at the role of parasitic worms// in treatment of inflammatory bowel disease.

Her research is part of a more than $10 million National Institutes of Health grant supporting the Food and Waterborne Diseases Integrated Research Network of laboratories launched by the National Institutes of Allergy and Infectious Diseases.

Some researchers argue that improved hygiene throughout the developed world may be responsible for inflammatory bowel disease, as well as a whole range of autoimmune disorders. According to this "hygiene hypothesis," immune systems require exposure to infections of all sorts early in life in order to develop sufficiently.

Intriguingly, inflammatory bowel disease, which has two forms – Crohn’s disease and ulcerative colitis – is virtually unknown in the developing world, while it is increasing dramatically in developed societies. When people from developing countries move to developed ones, their incidence of the disease tends to increase.

"We know from veterinary medicine that many bacterial and protozoan pathogens, especially those that multiply inside of cells, elicit an immune response in the host that would normally cause inflammation, but that worm parasites mount an anti-inflammatory defense that modulates it," said Mansfield, a professor of large animal clinical sciences. "The greater the immune response, the greater the anti-inflammatory effect.

"It's possible that the human immune system developed in a way that is dependent on parasitic worms to regulate immune responses."

The particular worm that Mansfield and colleagues are studying as a potential treatment is known as the whipworm, or Trichuris suis, which is a parasite that afflicts pigs. Early studies have shown that giving humans a concoction of whipworm eggs and Gatorade is very effective in treating inflam matory bowel disease.

Mansfield and colleagues are using some of the NIH funding to develop an animal model to test the effectiveness of the worms on inflammatory bowel disease and other maladies. Also, she is waiting for word on a new NIH grant that will support efforts to learn how the treatment works.

"The bottom line right now is that we know none of the mechanisms of how this works," she said.

Mansfield, as well as other researchers, also wants to apply this effort to a variety of autoimmune conditions, such as asthma, diabetes and multiple sclerosis. Some researchers suggest that all of these conditions can be explained as combinations of the hygiene hypothesis and genetics.

Contact: Linda Chadderdon, College of Veterinary Medicine: (517) 355-5165, chadderd@cvm.msu.edu; or Tom Oswald, University Relations: (517) 432-0920, oswald@msu.edu

Source: Eurekaler
'"/>




Related medicine news :

1. Parasitic infections and human immunity link found
2. Anti-Parasitic Drugs Useful in Reducing Damages of Congenital Toxoplasmosis
3. Inflammatory Bowel Diseases Cured By Parasitic Worms
4. An All Important Breakthrough Reached In Understanding T cell response For Parasitic Diseases
5. Multiple Sclerosis Patients Benefited by Parasitic Infections
6. Worms Learn To Choose Their Diet
7. Absorption Of Carbon Nanotube Measured In Worms Revolutionize Cancer Research
8. Inflammatory Bowel Diseases Cured By Parasitic Worms
9. Scientists Enlist Worms to Discover New Therapies for Huntington’s Diseas
10. Lean Protein Could Be Key to Obesity Drugs
11. Nasal Spray Could Take Drugs Direct to Brain.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/20/2017)... Centennial, CO (PRWEB) , ... August 20, 2017 , ... ... in the same household? If so, you may be interested in participating in ... The purpose of this research is to understand more about the relational aspects of ...
(Date:8/19/2017)... York, New York (PRWEB) , ... August 19, ... ... Street Health has announced that it is the first organization with pending recognition ... CDC’s National Diabetes Prevention Program (“DPP”) via group telehealth classes and live video ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners ... Orlando location as an interventional pain management physician. He brings a wealth of ... of migraine headaches, and significant experience in spinal cord stimulation for chronic pain. ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... specialized asset-light logistics provider of complex transport solutions for mission-critical and non-discretionary ... Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. (NYSE: RRTS). ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm ... for efforts to educate the local population on cancer realities while attracting donations to ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed and ...
Breaking Medicine News(10 mins):
(Date:7/28/2017)... July 28, 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") ... third quarter ended June 30, 2017, and updated its ... For the fiscal third quarter, Hill-Rom ... $0.68 per diluted share in the prior-year period. These ... $0.39 per diluted share primarily related to the non-cash ...
(Date:7/27/2017)... July 27, 2017  West Pharmaceutical Services, Inc. (NYSE: ... for the second-quarter 2017 and updated financial guidance for ... Second-Quarter 2017 Highlights Reported net sales ... the prior-year quarter. Net sales at constant currency (organic) ... EPS was $0.51, compared to $0.60 in the prior-year ...
(Date:7/26/2017)... , July 26, 2017 Sancilio Pharmaceuticals ... of our clinical trial evaluating Altemia TM , an ... (SCA) and Sickle Cell Disease (SCD). The SCOT Trial, ... the efficacy and safety of Altemia TM in ... conducted under US IND 125274. ...
Breaking Medicine Technology: